ID   A0N0D9_CTEID            Unreviewed;       212 AA.
AC   A0N0D9;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   SubName: Full=Insulin-like growth factor 2 {ECO:0000313|EMBL:AJG05607.1};
DE   SubName: Full=Insulin-like growth factor II {ECO:0000313|EMBL:ABK55615.1};
GN   Name=IGF-II {ECO:0000313|EMBL:ABK55615.1};
GN   Synonyms=IGF2b {ECO:0000313|EMBL:AJG05607.1};
OS   Ctenopharyngodon idella (Grass carp) (Leuciscus idella).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Xenocyprididae; Xenocypridinae; Ctenopharyngodon.
OX   NCBI_TaxID=7959 {ECO:0000313|EMBL:ABK55615.1};
RN   [1] {ECO:0000313|EMBL:ABK55615.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Fu G., Wong A.O.L.;
RT   "Molecular cloning of grass carp IGF-II and regulation of its mRNA
RT   expression in grass carp pituitary cells.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AJG05607.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20951190; DOI=10.1016/j.gene.2010.10.003;
RA   Yuan X.N., Jiang X.Y., Pu J.W., Li Z.R., Zou S.M.;
RT   "Functional conservation and divergence of duplicated insulin-like growth
RT   factor 2 genes in grass carp (Ctenopharyngodon idellus).";
RL   Gene 470:46-52(2011).
RN   [3] {ECO:0000313|EMBL:AJG05607.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zou S., Zheng G.;
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|RuleBase:RU000406}.
CC   -!- SIMILARITY: Belongs to the insulin family.
CC       {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR   EMBL; EF062860; ABK55615.1; -; mRNA.
DR   EMBL; KM889596; AJG05607.1; -; mRNA.
DR   AlphaFoldDB; A0N0D9; -.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   CDD; cd04368; IlGF; 1.
DR   Gene3D; 1.10.100.10; Insulin-like; 1.
DR   InterPro; IPR022334; IGF2.
DR   InterPro; IPR013576; IGF2_C.
DR   InterPro; IPR016179; Insulin-like.
DR   InterPro; IPR022350; Insulin-like_growth_factor.
DR   InterPro; IPR036438; Insulin-like_sf.
DR   InterPro; IPR022353; Insulin_CS.
DR   InterPro; IPR022352; Insulin_family.
DR   PANTHER; PTHR46886; INSULIN-LIKE GROWTH FACTOR II; 1.
DR   PANTHER; PTHR46886:SF1; INSULIN-LIKE GROWTH FACTOR II; 1.
DR   Pfam; PF08365; IGF2_C; 1.
DR   Pfam; PF00049; Insulin; 1.
DR   PRINTS; PR02002; INSLNLIKEGF.
DR   PRINTS; PR02006; INSLNLIKEGF2.
DR   PRINTS; PR00276; INSULINFAMLY.
DR   SMART; SM00078; IlGF; 1.
DR   SUPFAM; SSF56994; Insulin-like; 1.
DR   PROSITE; PS00262; INSULIN; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR622350-50};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406}.
FT   DOMAIN          51..108
FT                   /note="Insulin-like"
FT                   /evidence="ECO:0000259|SMART:SM00078"
FT   DISULFID        54..95
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT   DISULFID        66..108
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT   DISULFID        94..99
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
SQ   SEQUENCE   212 AA;  24449 MW;  3D790BB59FF03DA8 CRC64;
     MEDQLKHHSV CHTCLRTDSF INKVIKMYWS IRMPICILFL TLSAFEVASA ETLCGGELVD
     ALQFVCEDRG FYFSRPTSRS NSRRPQNRGI VEECCFSSCN LALLEQYCAK PAKSERDVSA
     TSLQVIPVMP ALKQEVPRKH VTVKYSKYDV WQRKAAQRLR RGVPAILRAK KFRRQAERIK
     AQEQLHHHRP LITLPSKLPP ILLPTENYVS HK
//