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Protein
Submitted name:

Peroxisome proliferator activated receptor gamma 2

Gene

Pparg

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. drug binding Source: Ensembl
  2. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
  3. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  2. cell maturation Source: Ensembl
  3. cellular response to hyperoxia Source: Ensembl
  4. cellular response to insulin stimulus Source: Ensembl
  5. cellular response to prostaglandin E stimulus Source: Ensembl
  6. cellular response to retinoic acid Source: Ensembl
  7. cellular response to vitamin E Source: Ensembl
  8. fatty acid oxidation Source: Ensembl
  9. glucose homeostasis Source: Ensembl
  10. heart development Source: Ensembl
  11. lipoprotein transport Source: Ensembl
  12. low-density lipoprotein particle receptor biosynthetic process Source: Ensembl
  13. monocyte differentiation Source: Ensembl
  14. negative regulation of acute inflammatory response Source: Ensembl
  15. negative regulation of cell growth Source: Ensembl
  16. negative regulation of cholesterol storage Source: Ensembl
  17. negative regulation of collagen biosynthetic process Source: Ensembl
  18. negative regulation of interferon-gamma-mediated signaling pathway Source: Ensembl
  19. negative regulation of pancreatic stellate cell proliferation Source: Ensembl
  20. negative regulation of receptor biosynthetic process Source: Ensembl
  21. negative regulation of sequestering of triglyceride Source: Ensembl
  22. negative regulation of smooth muscle cell proliferation Source: Ensembl
  23. negative regulation of telomerase activity Source: Ensembl
  24. organ regeneration Source: Ensembl
  25. peroxisome proliferator activated receptor signaling pathway Source: Ensembl
  26. positive regulation of fatty acid oxidation Source: Ensembl
  27. positive regulation of oligodendrocyte differentiation Source: Ensembl
  28. positive regulation of phagocytosis, engulfment Source: Ensembl
  29. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  30. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  31. regulation of blood pressure Source: Ensembl
  32. regulation of fat cell differentiation Source: Ensembl
  33. response to caffeine Source: Ensembl
  34. response to cold Source: Ensembl
  35. response to diuretic Source: Ensembl
  36. response to estrogen Source: Ensembl
  37. response to immobilization stress Source: Ensembl
  38. response to low-density lipoprotein particle Source: Ensembl
  39. response to mechanical stimulus Source: Ensembl
  40. response to metformin Source: Ensembl
  41. response to starvation Source: Ensembl
  42. response to vitamin A Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiREACT_276696. Nuclear Receptor transcription pathway.
REACT_309805. Transcriptional regulation of white adipocyte differentiation.

Names & Taxonomyi

Protein namesi
Submitted name:
Peroxisome proliferator activated receptor gamma 2Imported
Gene namesi
Name:PpargImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiA0N0D0.
ExpressionAtlasiA0N0D0. baseline and differential.
GenevestigatoriA0N0D0.

Sequencei

Sequence statusi: Fragment.

A0N0D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
MGETLGDSPV DPEHGAFADA LPMSTS
Length:26
Mass (Da):2,633
Last modified:December 11, 2006 - v1
Checksum:i2CC1FA0E15392FA8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei26 – 261Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF062479 Genomic DNA. Translation: ABK39950.1.
UniGeneiMm.3020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF062479 Genomic DNA. Translation: ABK39950.1.
UniGeneiMm.3020.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

ReactomeiREACT_276696. Nuclear Receptor transcription pathway.
REACT_309805. Transcriptional regulation of white adipocyte differentiation.

Miscellaneous databases

NextBioi35542228.

Gene expression databases

BgeeiA0N0D0.
ExpressionAtlasiA0N0D0. baseline and differential.
GenevestigatoriA0N0D0.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. Ackert-Bicknell C.L., Rosen C.J.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C3H/HeJImported.

Entry informationi

Entry nameiA0N0D0_MOUSE
AccessioniPrimary (citable) accession number: A0N0D0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 11, 2006
Last sequence update: December 11, 2006
Last modified: March 31, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.