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A0MS83

- ZN148_DANRE

UniProt

A0MS83 - ZN148_DANRE

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Protein
Zinc finger protein 148
Gene
znf148, zbp89, si:dkey-101k6.6
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in transcriptional regulation. Represses the transcription of a number of genes. Required for primitive and definitive hematopoiesis during embryonic development.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri180 – 20223C2H2-type 1
Add
BLAST
Zinc fingeri208 – 23023C2H2-type 2
Add
BLAST
Zinc fingeri236 – 25823C2H2-type 3
Add
BLAST
Zinc fingeri264 – 28724C2H2-type 4
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. hemopoiesis Source: ZFIN
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 148
Alternative name(s):
Transcription factor ZBP-89
Zinc finger DNA-binding protein 89
Gene namesi
Name:znf148
Synonyms:zbp89
ORF Names:si:dkey-101k6.6
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-030131-8769. znf148.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 808808Zinc finger protein 148
PRO_0000354690Add
BLAST

Expressioni

Developmental stagei

Detected in posterior lateral mesoderm, head mesenchyme and the intermediate cell mass in embryos 24 hours after fertilization.1 Publication

Gene expression databases

BgeeiA0MS83.

Structurei

3D structure databases

ProteinModelPortaliA0MS83.
SMRiA0MS83. Positions 233-263.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi58 – 8730Asp/Glu-rich
Add
BLAST
Compositional biasi151 – 1566Poly-Lys

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00530000063238.
HOGENOMiHOG000293204.
HOVERGENiHBG054247.
InParanoidiA0MS83.
OMAiNDAYLNN.
OrthoDBiEOG76QFGM.
PhylomeDBiA0MS83.
TreeFamiTF331779.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0MS83-1 [UniParc]FASTAAdd to Basket

« Hide

MNIDDKLEGM LLKYSPVGLQ HPSRGLGPSR VDGRGRRGSL DMTLGERSLA    50
NHPLLAEDDD DEDEEEDDDD DLAGEGLTSH DLISQDDLMV HEETVKNDGQ 100
DEAAFSHRIS NKLHYTLSMP VNIKQEMKVP DSLILNKKEK KPGRDPSDCH 150
KKKKRKQRSP AKILTINEDG SLGHQNPKSH ICEHCNAAFR TNYHLQRHVF 200
IHTGEKPFQC NQCDMRFIQK YLLQRHEKIH TGEKPFRCDE CGMKFIQKYH 250
MERHKRTHSG EKPYQCDYCH QFFSRTDRVL KHRRMCHENK DRKVQKTAVK 300
DSPLRTPENL GFSFPAKDCT LPKKKRQKTS DKSRASITNP AVDKVVEADM 350
DEKTEDRLAK SECLPLYAVA TKVKDEYVVT DYSVELPDSP PGSRHLAGEE 400
SNDEIISPPK LVLKKIASRR GFKQQALEQS QSLSPLSSFE ESKVTRYTFE 450
IVDNKGLLDV ETNPDMESVE ALQVGQAKPT GSSTNYDDAM QFVKKRRYLQ 500
AATANTSRDY ALNVSSIVSQ SSVTQASVAT VIDETVPATI LSETQTLNVE 550
IKSSNEKNVL PDEVLQTLLD HYSNKANGQA EISFSVADTE VTSSISINSS 600
DESSPAEALV TSSQAPPTEK ASLLQEYSKF LQQALERTSQ NDTYLNNQSL 650
TFVNDSASLA GQPLFSTEKQ FTSPPRFRPT MNSPLRSTLE KPNFNLLVDT 700
QHSFSFSGDE TNPSSVSPTE DFLDQVTSPK KTDPQSISQT FQITTFDQNF 750
RSQFPSSRSG ISPQFSIASG QVTLRGHGGA DFPEFSLVNE TRTQLTSSPD 800
ATSSQTFG 808
Length:808
Mass (Da):90,507
Last modified:November 25, 2008 - v2
Checksum:iB87251E494294A77
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661E → DD in AAI63289. 1 Publication
Sequence conflicti325 – 3251K → T in ABK40532. 1 Publication
Sequence conflicti429 – 4291Q → E in AAI63289. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF032416 mRNA. Translation: ABK40532.1.
BX255930 Genomic DNA. Translation: CAQ14829.1.
BC163289 mRNA. Translation: AAI63289.1.
RefSeqiNP_001073649.1. NM_001080180.1.
UniGeneiDr.76709.

Genome annotation databases

EnsembliENSDART00000077389; ENSDARP00000071856; ENSDARG00000055106.
GeneIDi560300.
KEGGidre:560300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF032416 mRNA. Translation: ABK40532.1 .
BX255930 Genomic DNA. Translation: CAQ14829.1 .
BC163289 mRNA. Translation: AAI63289.1 .
RefSeqi NP_001073649.1. NM_001080180.1.
UniGenei Dr.76709.

3D structure databases

ProteinModelPortali A0MS83.
SMRi A0MS83. Positions 233-263.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000077389 ; ENSDARP00000071856 ; ENSDARG00000055106 .
GeneIDi 560300.
KEGGi dre:560300.

Organism-specific databases

CTDi 7707.
ZFINi ZDB-GENE-030131-8769. znf148.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00530000063238.
HOGENOMi HOG000293204.
HOVERGENi HBG054247.
InParanoidi A0MS83.
OMAi NDAYLNN.
OrthoDBi EOG76QFGM.
PhylomeDBi A0MS83.
TreeFami TF331779.

Miscellaneous databases

NextBioi 20883373.
PROi A0MS83.

Gene expression databases

Bgeei A0MS83.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 4 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcription factor ZBP-89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells."
    Li X., Xiong J.-W., Shelley C.S., Park H., Arnaout M.A.
    Development 133:3641-3650(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
    Tissue: Embryo.
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiZN148_DANRE
AccessioniPrimary (citable) accession number: A0MS83
Secondary accession number(s): B0S5L9, B3DIY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: April 16, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Knock-down of the znf148 mRNA disrupts both primitive and definitive hematopoiesis, but does not affect primary blood vessel formation. Most embryos die before four days after fertilization.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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