Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 148

Gene

znf148

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in transcriptional regulation. Represses the transcription of a number of genes. Required for primitive and definitive hematopoiesis during embryonic development.1 Publication

Miscellaneous

Knock-down of the znf148 mRNA disrupts both primitive and definitive hematopoiesis, but does not affect primary blood vessel formation. Most embryos die before four days after fertilization.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri180 – 202C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri208 – 230C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri236 – 258C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri264 – 287C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • hemopoiesis Source: ZFIN
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 148
Alternative name(s):
Transcription factor ZBP-89
Zinc finger DNA-binding protein 89
Gene namesi
Name:znf148
Synonyms:zbp89
ORF Names:si:dkey-101k6.6
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-030131-8769 znf148

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003546901 – 808Zinc finger protein 148Add BLAST808

Proteomic databases

PaxDbiA0MS83
PRIDEiA0MS83

Expressioni

Developmental stagei

Detected in posterior lateral mesoderm, head mesenchyme and the intermediate cell mass in embryos 24 hours after fertilization.1 Publication

Gene expression databases

BgeeiENSDARG00000055106
ExpressionAtlasiA0MS83 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000071856

Structurei

3D structure databases

ProteinModelPortaliA0MS83
SMRiA0MS83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi58 – 87Asp/Glu-richAdd BLAST30
Compositional biasi151 – 156Poly-Lys6

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri180 – 202C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri208 – 230C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri236 – 258C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri264 – 287C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063238
HOGENOMiHOG000293204
HOVERGENiHBG054247
InParanoidiA0MS83
OMAiEMISHDE
OrthoDBiEOG091G02EU
PhylomeDBiA0MS83
TreeFamiTF331779

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

A0MS83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIDDKLEGM LLKYSPVGLQ HPSRGLGPSR VDGRGRRGSL DMTLGERSLA
60 70 80 90 100
NHPLLAEDDD DEDEEEDDDD DLAGEGLTSH DLISQDDLMV HEETVKNDGQ
110 120 130 140 150
DEAAFSHRIS NKLHYTLSMP VNIKQEMKVP DSLILNKKEK KPGRDPSDCH
160 170 180 190 200
KKKKRKQRSP AKILTINEDG SLGHQNPKSH ICEHCNAAFR TNYHLQRHVF
210 220 230 240 250
IHTGEKPFQC NQCDMRFIQK YLLQRHEKIH TGEKPFRCDE CGMKFIQKYH
260 270 280 290 300
MERHKRTHSG EKPYQCDYCH QFFSRTDRVL KHRRMCHENK DRKVQKTAVK
310 320 330 340 350
DSPLRTPENL GFSFPAKDCT LPKKKRQKTS DKSRASITNP AVDKVVEADM
360 370 380 390 400
DEKTEDRLAK SECLPLYAVA TKVKDEYVVT DYSVELPDSP PGSRHLAGEE
410 420 430 440 450
SNDEIISPPK LVLKKIASRR GFKQQALEQS QSLSPLSSFE ESKVTRYTFE
460 470 480 490 500
IVDNKGLLDV ETNPDMESVE ALQVGQAKPT GSSTNYDDAM QFVKKRRYLQ
510 520 530 540 550
AATANTSRDY ALNVSSIVSQ SSVTQASVAT VIDETVPATI LSETQTLNVE
560 570 580 590 600
IKSSNEKNVL PDEVLQTLLD HYSNKANGQA EISFSVADTE VTSSISINSS
610 620 630 640 650
DESSPAEALV TSSQAPPTEK ASLLQEYSKF LQQALERTSQ NDTYLNNQSL
660 670 680 690 700
TFVNDSASLA GQPLFSTEKQ FTSPPRFRPT MNSPLRSTLE KPNFNLLVDT
710 720 730 740 750
QHSFSFSGDE TNPSSVSPTE DFLDQVTSPK KTDPQSISQT FQITTFDQNF
760 770 780 790 800
RSQFPSSRSG ISPQFSIASG QVTLRGHGGA DFPEFSLVNE TRTQLTSSPD

ATSSQTFG
Length:808
Mass (Da):90,507
Last modified:November 25, 2008 - v2
Checksum:iB87251E494294A77
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66E → DD in AAI63289 (Ref. 3) Curated1
Sequence conflicti325K → T in ABK40532 (PubMed:16914492).Curated1
Sequence conflicti429Q → E in AAI63289 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF032416 mRNA Translation: ABK40532.1
BX255930 Genomic DNA Translation: CAQ14829.1
BC163289 mRNA Translation: AAI63289.1
RefSeqiNP_001073649.1, NM_001080180.1
UniGeneiDr.76709

Genome annotation databases

EnsembliENSDART00000077389; ENSDARP00000071856; ENSDARG00000055106
GeneIDi560300
KEGGidre:560300

Similar proteinsi

Entry informationi

Entry nameiZN148_DANRE
AccessioniPrimary (citable) accession number: A0MS83
Secondary accession number(s): B0S5L9, B3DIY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 81 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health