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Protein

Protein E7

Gene

E7

Organism
Human papillomavirus type 16
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

E7 protein has both transforming and trans-activating activities.UniRule annotation
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri58 – 9437UniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotationSAAS annotation

Keywords - Biological processi

G1/S host cell cycle checkpoint dysregulation by virusUniRule annotationSAAS annotation, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virusUniRule annotationSAAS annotation, Modulation of host cell cycle by virus, Transcription, Transcription regulationUniRule annotationSAAS annotation, Viral immunoevasion

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein E7UniRule annotationSAAS annotation
Gene namesi
Name:E7UniRule annotationImported
OrganismiHuman papillomavirus type 16Imported
Taxonomic identifieri333760 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host cytoplasm UniRule annotation
  • Host nucleus UniRule annotation

  • Note: Predominantly found in the host nucleus.UniRule annotation
  • Host nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasmUniRule annotationSAAS annotation, Host nucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Keywords - Diseasei

OncogeneUniRule annotation

PTM / Processingi

Post-translational modificationi

Highly phosphorylated.UniRule annotation

Expressioni

Keywords - Developmental stagei

Early proteinUniRule annotation

Interactioni

Subunit structurei

Homodimer. Homooligomer. Interacts with host RB1; this interaction induces dissociation of RB1-E2F1 complex thereby disrupting RB1 activity. Interacts with host EP300; this interaction represses EP300 transcriptional activity. Interacts with protein E2; this interaction inhibits E7 oncogenic activity.UniRule annotation

Protein-protein interaction databases

IntActiA0MPS7. 3 interactions.
MINTiMINT-6664727.

Structurei

3D structure databases

ProteinModelPortaliA0MPS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 4040DisorderedUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi22 – 265LXCXE motif; interaction with host RB1UniRule annotation
Motifi76 – 849Nuclear export signalUniRule annotation

Sequence similaritiesi

Belongs to the papillomaviridae E7 protein family.UniRule annotationSAAS annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri58 – 9437UniRule annotationAdd
BLAST

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_04004. PPV_E7. 1 hit.
InterProiIPR000148. Papilloma_E7.
[Graphical view]
PfamiPF00527. E7. 1 hit.
[Graphical view]
PIRSFiPIRSF003407. Papvi_E7. 1 hit.

Sequencei

Sequence statusi: Complete.

A0MPS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHGDTPTLHE YMLDLQPETT DLYCYEQLND SSEEEDEIDG PAGQAEPDRA
60 70 80 90
HYNIVTFCCK CDFTLRLCVQ STHVDIRTLE DLLMGTLGIV CPICSQKP
Length:98
Mass (Da):11,082
Last modified:December 12, 2006 - v1
Checksum:i9BD6124EFA09B9EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF029183 Genomic DNA. Translation: ABK32512.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF029183 Genomic DNA. Translation: ABK32512.1.

3D structure databases

ProteinModelPortaliA0MPS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA0MPS7. 3 interactions.
MINTiMINT-6664727.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_04004. PPV_E7. 1 hit.
InterProiIPR000148. Papilloma_E7.
[Graphical view]
PfamiPF00527. E7. 1 hit.
[Graphical view]
PIRSFiPIRSF003407. Papvi_E7. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA0MPS7_HPV16
AccessioniPrimary (citable) accession number: A0MPS7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: September 7, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.