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A0MLS4

- GHRL_PAPHA

UniProt

A0MLS4 - GHRL_PAPHA

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Protein

Appetite-regulating hormone

Gene
GHRL
Organism
Papio hamadryas (Hamadryas baboon)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation By similarity.
Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility By similarity.

GO - Molecular functioni

  1. ghrelin receptor binding Source: UniProtKB
  2. growth hormone-releasing hormone activity Source: UniProtKB
  3. hormone activity Source: UniProtKB
  4. protein tyrosine kinase activator activity Source: UniProtKB

GO - Biological processi

  1. actin polymerization or depolymerization Source: UniProtKB
  2. activation of MAPK activity Source: UniProtKB
  3. decidualization Source: UniProtKB
  4. dendrite development Source: UniProtKB
  5. negative regulation of apoptotic process Source: UniProtKB
  6. negative regulation of endothelial cell proliferation Source: UniProtKB
  7. negative regulation of inflammatory response Source: UniProtKB
  8. negative regulation of insulin secretion Source: UniProtKB
  9. negative regulation of interleukin-1 beta production Source: UniProtKB
  10. negative regulation of interleukin-6 biosynthetic process Source: UniProtKB
  11. negative regulation of tumor necrosis factor biosynthetic process Source: UniProtKB
  12. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  13. positive regulation of insulin secretion Source: UniProtKB
  14. positive regulation of protein tyrosine kinase activity Source: GOC
  15. positive regulation of response to food Source: UniProtKB
  16. positive regulation of synapse assembly Source: UniProtKB
  17. regulation of cell proliferation Source: UniProtKB
  18. regulation of response to food Source: UniProtKB
  19. response to estrogen Source: UniProtKB
  20. response to hormone Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Appetite-regulating hormone
Alternative name(s):
Growth hormone secretagogue
Growth hormone-releasing peptide
Motilin-related peptide
Cleaved into the following 2 chains:
Gene namesi
Name:GHRL
OrganismiPapio hamadryas (Hamadryas baboon)
Taxonomic identifieri9557 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. axon Source: UniProtKB
  2. extracellular region Source: UniProtKB
  3. extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 By similarityAdd
BLAST
Peptidei24 – 5128GhrelinPRO_0000278843Add
BLAST
Propeptidei52 – 7524Removed in mature form By similarityPRO_0000278844Add
BLAST
Peptidei76 – 9823Obestatin By similarityPRO_0000278845Add
BLAST
Propeptidei99 – 11719Removed in mature form By similarityPRO_0000278846Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi26 – 261O-octanoyl serine By similarity
Modified residuei98 – 981Leucine amide By similarity

Post-translational modificationi

O-octanoylation is essential for ghrelin activity By similarity.
Amidation of Leu-98 is essential for obestatin activity By similarity.

Keywords - PTMi

Amidation, Lipoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the motilin family.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG018522.

Family and domain databases

InterProiIPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
IPR005441. Preproghrelin.
[Graphical view]
PANTHERiPTHR14122. PTHR14122. 1 hit.
PfamiPF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
[Graphical view]
PRINTSiPR01624. GHRELIN.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0MLS4-1 [UniParc]FASTAAdd to Basket

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MPSPGTVCSL LLLGMLWLDL AMAGSSFLSP EHQRAQQRKE SKKPPAKLQP    50
RALGGWLRPE DGDQAEGAED ELEIQFNAPF DVGIKLSGVQ YQQHSQALGK 100
FLQDILWEEA KEAPADK 117
Length:117
Mass (Da):12,913
Last modified:December 12, 2006 - v1
Checksum:i1B634ACE1E1F19FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ987858 mRNA. Translation: ABJ91203.1.

Cross-referencesi

Web resourcesi

Protein Spotlight

Gut feelings - Issue 66 of January 2006

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ987858 mRNA. Translation: ABJ91203.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG018522.

Family and domain databases

InterProi IPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
IPR005441. Preproghrelin.
[Graphical view ]
PANTHERi PTHR14122. PTHR14122. 1 hit.
Pfami PF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
[Graphical view ]
PRINTSi PR01624. GHRELIN.
ProtoNeti Search...

Publicationsi

  1. "Quantitative genetic analysis and characterization of ghrelin in baboons."
    Voruganti V.S., Tejero M.E., Proffitt J.M., Cole S.A., Freeland-Graves J.H., Comuzzie A.G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGHRL_PAPHA
AccessioniPrimary (citable) accession number: A0MLS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 12, 2006
Last modified: April 16, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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