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A0MLS4

- GHRL_PAPHA

UniProt

A0MLS4 - GHRL_PAPHA

Protein

Appetite-regulating hormone

Gene

GHRL

Organism
Papio hamadryas (Hamadryas baboon)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
  1. Functioni

    Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation By similarity.By similarity
    Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility By similarity.By similarity

    GO - Molecular functioni

    1. ghrelin receptor binding Source: UniProtKB
    2. growth hormone-releasing hormone activity Source: UniProtKB
    3. hormone activity Source: UniProtKB
    4. protein tyrosine kinase activator activity Source: UniProtKB

    GO - Biological processi

    1. actin polymerization or depolymerization Source: UniProtKB
    2. activation of MAPK activity Source: UniProtKB
    3. decidualization Source: UniProtKB
    4. dendrite development Source: UniProtKB
    5. negative regulation of apoptotic process Source: UniProtKB
    6. negative regulation of endothelial cell proliferation Source: UniProtKB
    7. negative regulation of inflammatory response Source: UniProtKB
    8. negative regulation of insulin secretion Source: UniProtKB
    9. negative regulation of interleukin-1 beta production Source: UniProtKB
    10. negative regulation of interleukin-6 biosynthetic process Source: UniProtKB
    11. negative regulation of tumor necrosis factor biosynthetic process Source: UniProtKB
    12. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
    13. positive regulation of insulin secretion Source: UniProtKB
    14. positive regulation of protein tyrosine kinase activity Source: GOC
    15. positive regulation of response to food Source: UniProtKB
    16. positive regulation of synapse assembly Source: UniProtKB
    17. regulation of cell proliferation Source: UniProtKB
    18. regulation of response to food Source: UniProtKB
    19. response to estrogen Source: UniProtKB
    20. response to hormone Source: UniProtKB

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Appetite-regulating hormone
    Alternative name(s):
    Growth hormone secretagogue
    Growth hormone-releasing peptide
    Motilin-related peptide
    Cleaved into the following 2 chains:
    Gene namesi
    Name:GHRL
    OrganismiPapio hamadryas (Hamadryas baboon)
    Taxonomic identifieri9557 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. axon Source: UniProtKB
    2. extracellular region Source: UniProtKB
    3. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Peptidei24 – 5128GhrelinPRO_0000278843Add
    BLAST
    Propeptidei52 – 7524Removed in mature formBy similarityPRO_0000278844Add
    BLAST
    Peptidei76 – 9823ObestatinBy similarityPRO_0000278845Add
    BLAST
    Propeptidei99 – 11719Removed in mature formBy similarityPRO_0000278846Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi26 – 261O-octanoyl serineBy similarity
    Modified residuei98 – 981Leucine amideBy similarity

    Post-translational modificationi

    O-octanoylation is essential for ghrelin activity.By similarity
    Amidation of Leu-98 is essential for obestatin activity.By similarity

    Keywords - PTMi

    Amidation, Lipoprotein

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the motilin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG018522.

    Family and domain databases

    InterProiIPR006737. Motilin_assoc.
    IPR006738. Motilin_ghrelin.
    IPR005441. Preproghrelin.
    [Graphical view]
    PANTHERiPTHR14122. PTHR14122. 1 hit.
    PfamiPF04643. Motilin_assoc. 1 hit.
    PF04644. Motilin_ghrelin. 1 hit.
    [Graphical view]
    PRINTSiPR01624. GHRELIN.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A0MLS4-1 [UniParc]FASTAAdd to Basket

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    MPSPGTVCSL LLLGMLWLDL AMAGSSFLSP EHQRAQQRKE SKKPPAKLQP    50
    RALGGWLRPE DGDQAEGAED ELEIQFNAPF DVGIKLSGVQ YQQHSQALGK 100
    FLQDILWEEA KEAPADK 117
    Length:117
    Mass (Da):12,913
    Last modified:December 12, 2006 - v1
    Checksum:i1B634ACE1E1F19FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ987858 mRNA. Translation: ABJ91203.1.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Gut feelings - Issue 66 of January 2006

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ987858 mRNA. Translation: ABJ91203.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG018522.

    Family and domain databases

    InterProi IPR006737. Motilin_assoc.
    IPR006738. Motilin_ghrelin.
    IPR005441. Preproghrelin.
    [Graphical view ]
    PANTHERi PTHR14122. PTHR14122. 1 hit.
    Pfami PF04643. Motilin_assoc. 1 hit.
    PF04644. Motilin_ghrelin. 1 hit.
    [Graphical view ]
    PRINTSi PR01624. GHRELIN.
    ProtoNeti Search...

    Publicationsi

    1. "Quantitative genetic analysis and characterization of ghrelin in baboons."
      Voruganti V.S., Tejero M.E., Proffitt J.M., Cole S.A., Freeland-Graves J.H., Comuzzie A.G.
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiGHRL_PAPHA
    AccessioniPrimary (citable) accession number: A0MLS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3