A0MJA6 (A0MJA6_MACFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Niemann-Pick C1-like 1 protein EMBL ABK32536.1

Gene names

Name:

NPC1L1 EMBL ABK32536.1

Organism

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) EMBL ABK32536.1

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	1332 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological process	cholesterol transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular function	hedgehog receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0MJA6 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: B983F0EBD7E0EFD8	FASTA	1,332	145,588
	10 20 30 40 50 60 MAEAGLRGWL LWALLLHLAQ SEPYTPIHQP GYCAFYDECG KNPELSGGLM TLSNVSCLSN 70 80 90 100 110 120 TPARNITGDH LILLQRICPR LYTGPNTQAC CSAKQLVSLE ASLSITKALL TRCPACSDNF 130 140 150 160 170 180 VSLHCHNTCS PNQSLFINVT RVAQLGAGQL PAVVAYEAFY QHSFAEQSYD SCSRVHIPAA 190 200 210 220 230 240 ATLAVGSMCG VYGSALCNAQ RWLNFQGDTG NGLAPLDITF HLLEPGQAVG SGIQPLNEGV 250 260 270 280 290 300 ARCNESQGDD AVACSCQDCA ASCPAIAHPQ ALDSTFRLGR MPGGLVLIII LCSVFTVVAI 310 320 330 340 350 360 LLVGLRVAPT RDKSKTVDPK KGTSLSDKLS FSTHTLLGQF FQGWGTWVAS WPLTILVLSV 370 380 390 400 410 420 IPVVVLAAGL VFTELTTDPV ELWSAPNSQA RSEKAFHDQH FGPFFRTNQV ILTAPNRSSY 430 440 450 460 470 480 RYDSLLLGPK NFSGILDLDL LLELLELQER LRHLQVWSPE AQRNISLQHI CYAPLNPDNT 490 500 510 520 530 540 SLSDCCINSL LQYFQNNRTL LLLTANQTLM GQTSQVDWRD HFLYCANAPL TFKDGTALAL 550 560 570 580 590 600 SCMADYGAPV FPFLAVGGYK GKDYSEAEAL IMTFSLNNYP AGDPRLAQAQ LWEEAFLEEM 610 620 630 640 650 660 RAFQRRTAGK FQVTFMAERS LEDEINRTTA EDLPIFATSY IVIFLYISLA LGSYSSWSRV 670 680 690 700 710 720 MVDSKATLGL GGVAVVLGAV MAAMGFFSYL GIRSSLIILQ VVPFLVLSVG ADNIFIFVLE 730 740 750 760 770 780 YQRLPRRPGE PREVHIGRAL GRVAPSMLLC SLSEAICFFL GALTPMPAVR TFALTSGLAV 790 800 810 820 830 840 VLDFLLQMSA FVALLSLDSK RQEASRLDVC CCVKPRELPL PGQGEGFLLG LFRKAYVPFL 850 860 870 880 890 900 LHWITRGVVL LLFLALFGVS LYYMCHISVG LDQELALPKD SYLLDYFLFL NRYFETGAPV 910 920 930 940 950 960 YFVTTSGYNF SSEAGMNAIC SSAGCNNFSF TQKIQYATEF PEQSYLAIPA SSWVDDFIDW 970 980 990 1000 1010 1020 LTPSSCCRLY ISGPNKDQFC PSTVNSLNCL KNCLSITMGS VRPSVEQFYK YLPWFLNDRP 1030 1040 1050 1060 1070 1080 NIKCPKGGLG AYSTSVNLTS DGQVLASRFM AYHKPLKNSQ DYTEALRAAR ELAANITADL 1090 1100 1110 1120 1130 1140 RKVPGTDPAF EVFPYTVTNV FYEQYLTILP EGLFMLSLCL VPTFAVCCLL LGLDLRSGLL 1150 1160 1170 1180 1190 1200 NLLSIIMILV DTVGFMALWG ISYNAVSLIN LVSAVGMSVE FVSHITRSFA ISTKPTRLER 1210 1220 1230 1240 1250 1260 AKEATISMGS AVFAGVAMTN LPGILVLGLA KAQLIQIFFF RLNLLITLLG LLHGLVFLPV 1270 1280 1290 1300 1310 1320 ILSYVGPDIN PALALEQKLA EEAAAAAIAA SYPNHPSRVS TADNIYVNHS FEGSIKGAGA 1330 VSNFLPNNGR QF

References

[1]

"In vivo responsiveness to ezetimibe correlates with niemann-pick C1 like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs." Hawes B.E., O'neill K.A., Yao X., Crona J.H., Davis H.R. Jr, Graziano M.P., Altmann S.W. Mol. Pharmacol. 71:19-29(2007) [PubMed: 17005902] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Jejunum EMBL ABK32536.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ897678 mRNA. Translation: ABK32536.1.
3D structure databases
ProteinModelPortal	A0MJA6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG003913.
Family and domain databases
InterPro	IPR004765. NP_C_type. IPR003392. Patched. IPR000731. SSD. [Graphical view]
Pfam	PF02460. Patched. 1 hit. [Graphical view]
TIGRFAMs	TIGR00917. 2A060601. 1 hit.
PROSITE	PS50156. SSD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A0MJA6_MACFA

Accession

Primary (citable) accession number: A0MJA6

Entry history

Integrated into UniProtKB/TrEMBL:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	March 8, 2011
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)