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Protein
Submitted name:

Niemann-Pick C1-like 1 protein

Gene

NPC1L1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CFA-8963678. Intestinal lipid absorption.

Names & Taxonomyi

Protein namesi
Submitted name:
Niemann-Pick C1-like 1 proteinImported
Gene namesi
Name:NPC1L1Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei276 – 303HelicalSequence analysisAdd BLAST28
Transmembranei351 – 373HelicalSequence analysisAdd BLAST23
Transmembranei633 – 654HelicalSequence analysisAdd BLAST22
Transmembranei666 – 690HelicalSequence analysisAdd BLAST25
Transmembranei696 – 719HelicalSequence analysisAdd BLAST24
Transmembranei739 – 761HelicalSequence analysisAdd BLAST23
Transmembranei773 – 797HelicalSequence analysisAdd BLAST25
Transmembranei844 – 864HelicalSequence analysisAdd BLAST21
Transmembranei1113 – 1132HelicalSequence analysisAdd BLAST20
Transmembranei1139 – 1159HelicalSequence analysisAdd BLAST21
Transmembranei1165 – 1185HelicalSequence analysisAdd BLAST21
Transmembranei1206 – 1230HelicalSequence analysisAdd BLAST25
Transmembranei1242 – 1265HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5301.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500262793922 – 1325Sequence analysisAdd BLAST1304

Proteomic databases

PaxDbiA0MJA4.

Structurei

3D structure databases

ProteinModelPortaliA0MJA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini632 – 797SSDInterPro annotationAdd BLAST166

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1933. Eukaryota.
ENOG410XR54. LUCA.
HOGENOMiHOG000204033.
HOVERGENiHBG003913.
KOiK14461.

Family and domain databases

InterProiView protein in InterPro
IPR004765. NP_C_type.
IPR032190. NPC1_N.
IPR003392. Ptc/Disp.
IPR000731. SSD.
PfamiView protein in Pfam
PF16414. NPC1_N. 1 hit.
PF02460. Patched. 1 hit.
PF12349. Sterol-sensing. 1 hit.
TIGRFAMsiTIGR00917. 2A060601. 1 hit.
PROSITEiView protein in PROSITE
PS50156. SSD. 1 hit.

Sequencei

Sequence statusi: Complete.

A0MJA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTGLRGWL LWALLLHVAQ SELYTPIHQP GYCAFYDECG KNPELSGGLA
60 70 80 90 100
PLSNVSCLSN TPALRVTGEH LTLLQRICPR LYTGTTTYAC CSPKQLLSLE
110 120 130 140 150
TSLAVTKALL TRCPTCSDNF VNLHCQNTCS PNQSLFINVT RVAGGGGGRP
160 170 180 190 200
QAVVAYEAFY QDTFAQQTYD SCSRVRIPAA ATLAVGTMCG VYGSTLCNAQ
210 220 230 240 250
RWLNFQGDTS NGLAPLDITF HLMEPGQALG SGMQALTGEI RPCNESQGNG
260 270 280 290 300
TVACSCQDCA ASCPTIPQPQ ALDSTFYLGG LEGGLALVII LCSAFALLTT
310 320 330 340 350
FLVGTRLASS CGKDKTPDPK AGMSLSDKLS LSTNVILSQC FQNWGTWVAS
360 370 380 390 400
WPLTILLVSI AVVLALSGGL AFVELTTDPV ELWSAPSSQA RSEKAFHDQH
410 420 430 440 450
FGPFLRTNQV ILTAPNRPSY HYDSLLLGPK NFSGVLASDL LLELLELQET
460 470 480 490 500
LRHLQVWSPE EQRHISLQDI CFAPLNPHNA SLSDCCINSL LQYFQSNRTH
510 520 530 540 550
LLLTANQTLT GQTSQVDWRD HFLYCANAPL TFKDGTALAL SCMADYGGPV
560 570 580 590 600
FPFLAVGGYK GKDYSEAEAL IMTFSLNNYA PGDPRLAQAK LWEAAFLEEM
610 620 630 640 650
KAFQRRTAGT FQVTFMAERS LEDEINRTTA EDLPIFGVSY IIIFLYISLA
660 670 680 690 700
LGSYSSWRRV PVDSKVTLGL GGVAVVLGAV TAAMGFFSYL GVPSSLVILQ
710 720 730 740 750
VVPFLVLAVG ADNIFIFVLE YQRLPRRPGE PREAHIGRAL GSVAPSMLLC
760 770 780 790 800
SLSEAICFFL GALTPMPAVK TFALISGFAI VLDFLLQVSA FVALLSLDSR
810 820 830 840 850
RQEASRLDVC CCVSAPKLPA PGQSEGLLLR VFRKFYVPVL LHRVTRAVVL
860 870 880 890 900
LLFTGLFGVG LYFMCHIRVG LDQELALPKD SYLLDYFFFL NRYFEVGAPV
910 920 930 940 950
YFVTTGGYNF SSEAGMNAVC SSAGCDSYSL TQKIQYATEF PEESYLAIPA
960 970 980 990 1000
SSWVDDFIDW LTPSSCCRLY AFGANKDKFC PSTVNSLACL KNCVNFTLGP
1010 1020 1030 1040 1050
VRPSVDQFHK YLPWFLSDPP NIKCPKGGLA AYNTSVHLGS DGQVLASRFM
1060 1070 1080 1090 1100
AYHKPLRNSE DYTEALRVSR ALAANITAQL RQVPGTDPAF EVFPYTITNV
1110 1120 1130 1140 1150
FYEQYLSVVP EGLFMLAICL LPTFVVCCLL LGMDLRSGLL NLFSIVMILV
1160 1170 1180 1190 1200
DTVGFMALWG ISYNAVSLIN LVTAVGISVE FVSHITRSFA VSTRPTRLER
1210 1220 1230 1240 1250
AKEATISMGS AVFAGVAMTN LPGILVLGLA KAQLIQIFFF RLNLLITVLG
1260 1270 1280 1290 1300
LLHGLVFLPV VLSYLGPDIN AALVLDQKKT EEAIGAPAHL VPTSTASSTY
1310 1320
VNYGFQHPAN GVVGDSSLPR SGPDL
Length:1,325
Mass (Da):143,895
Last modified:December 12, 2006 - v1
Checksum:i58466599059724CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ897676 mRNA. Translation: ABK32534.1.
RefSeqiNP_001091019.1. NM_001097550.1.
UniGeneiCfa.13279.

Genome annotation databases

GeneIDi610398.
KEGGicfa:610398.

Similar proteinsi

Entry informationi

Entry nameiA0MJA4_CANLF
AccessioniPrimary (citable) accession number: A0MJA4
Entry historyiIntegrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: September 27, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)