A0MH68 (AROF_CATRO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable phospho-2-dehydro-3-deoxyheptonate aldolase, chloroplastic
EC=2.5.1.54

Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
CrDHS1
DAHP synthase
Phospho-2-keto-3-deoxyheptonate aldolase

Gene names

Name:

DHS1

Organism

Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)

Taxonomic identifier

4058 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Gentianales › Apocynaceae › Rauvolfioideae › Vinceae › Catharanthus

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.
Subcellular location	Plastid › chloroplast Potential.
Sequence similarities	Belongs to the class-II DAHP synthase family.
Sequence caution	The sequence ABK29527.1 differs from that shown. Reason: Frameshift at position 63.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Chloroplast Plastid
Domain	Transit peptide
Molecular function	Transferase
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chloroplast Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 58	58	Chloroplast Potential
	Chain	59 – 493	435	Probable phospho-2-dehydro-3-deoxyheptonate aldolase, chloroplastic		PRO_0000312804

Sequences

	Sequence		Length	Mass (Da)
	A0MH68 [UniParc]. Last modified December 4, 2007. Version 2. Checksum: EF247BADC19098AB	FASTA	493	54,743
	10 20 30 40 50 60 MAMSNTSALA SKLLPSCKPH QPTLTFFSPS TTCQKKPRSS RPISAAVHVT QPPKTPISSA 70 80 90 100 110 120 TATKRRLSLL NGVWESWKSK KALQLPEYPD EGKLDGVLKT IEAFPPLVFA GEARSLEEKL 130 140 150 160 170 180 AQAAMGNAFL LQGGDCAESF KELMPLYSRY FQNTASDECR LTFGGQCPVI KVGRMAGQFA 190 200 210 220 230 240 KPRLDPFEEK DGLWLSGANG WPVAWEAYCK LQQLSPSRAL LLVVCCYAES HPMDLDFVEH 250 260 270 280 290 300 SEQGDRYQEL AHRVDEALGF MDACGLTVDH PIMATTEFWT SHECLLLPYE QALTREDSTS 310 320 330 340 350 360 GLFYDCSAHM LWVGERTRQL DGAHVEFLRG VANPLGIKVS QKMDPNELVN LIEILNPTNK 370 380 390 400 410 420 PGRITVIVRM GAENMRVKLP HLIRAVRGAG QIVTWVCDPM HGNTIKAPCG LKTRAFDAIL 430 440 450 460 470 480 AEVRAFYDVH EQEGTLPGTE CVGGSRTITY DDRQTRYHTH CDPRLNASQS LELAFIIAER 490 LRKEESVLNA HSP

References

[1]	Ramani S., Chelliah J. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ859024 mRNA. Translation: ABK29527.1. Frameshift.
3D structure databases
ProteinModelPortal	A0MH68.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002480. DAHP_synth_2. [Graphical view]
PANTHER	PTHR21337. DAHP_synth_2. 1 hit.
Pfam	PF01474. DAHP_synth_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROF_CATRO

Accession

Primary (citable) accession number: A0MH68

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	September 21, 2011
This is version 25 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program