A0M8X1 (A0M8X1_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Thyroid peroxidase EMBL AAY16985.1

Gene names

Name:

TPO EMBL AAY16985.1

Organism

Homo sapiens (Human) EMBL AAY16985.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	933 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Domain	EGF-like domain SAAS SAAS000436 RuleBase RU000459 Sushi SAAS SAAS000436
Molecular function	Oxidoreductase Peroxidase EMBL AAY16985.1
PTM	Disulfide bond SAAS SAAS000436
Gene Ontology (GO)
Biological_process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0M8X1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: E551C0B2EA80FA40	FASTA	933	102,945
	10 20 30 40 50 60 MRALAVLSVT LVMACTEAFF PFISRGKELL WGKPEESRVS SVLEESKRLV DTAMYATMQR 70 80 90 100 110 120 NLKKRGILSP AQLLSFSKLP EPTSGVIARA AEIMETSIQA MKRKVNLKTQ QSQHPTDALS 130 140 150 160 170 180 EDLLSIIANM SGCLPYMLPP KCPNTCLANK YRPITGACNN RDHPRWGASN TALARWLPPV 190 200 210 220 230 240 YEDGFSQPRG WNPGFLYNGF PLPPVREVTR HVIQVSNEVV TDDDRYSDLL MAWGQYIDHD 250 260 270 280 290 300 IAFTPQSTSK AAFGGGADCQ MTCENQNPCF PIQLPEEARP AAGTACLPFY RSSAACGTGD 310 320 330 340 350 360 QGALFGNLST ANPRQQMNGL TSFLDASTVY GSSPALERQL RNWTSAEGLL RVHARLRDSG 370 380 390 400 410 420 RAYLPFVPPR APAACAPEPG IPGETRGPCF LAGDGRATEV PSLTALHTLW LREHNRLAAA 430 440 450 460 470 480 LKALNAHWSA DAVYQEARKV VGALHQIITL RDYIPRILGP EAFQQYVGPY EGYDSTANPT 490 500 510 520 530 540 VSNVFSTAAF RFGHATIHPL VRRLDASFQE HPDLPGLWLH QAFFSPWTLL RGGGLDPLIR 550 560 570 580 590 600 GLLARPAKLQ VQDQLMNEEL TERLFVLSNS STLDLASINL QRGRDHGLPG YNEWREFCGL 610 620 630 640 650 660 PRLETPADLS TAIASRSVAD KILDLYKHPD NIDVWLGGLA ENFLPRARTG PLFACLIGKQ 670 680 690 700 710 720 MKALRDGDWF WWENSHVFTD AQRRELEKHS LSRVICDNTG LTRVPMDAFQ VGKFPEDFES 730 740 750 760 770 780 CDSIPGMNLE AWRETFPQDD KCGFPESVEN GDFVHCEESG RRVLVYSCRH GYELQGREQL 790 800 810 820 830 840 TCTQEGWDFQ PPLCKDVNEC ADGAHPPCHA SARCRNTKGG FQCLCADPYE LGDDGRTCVD 850 860 870 880 890 900 SGRLPRATWI SMSLAALLIG GFAGLTSTVI CRWTRTGTKS TLPISETGGG TPELRCGKHQ 910 920 930 AVGTSPQRAA AQDSEQESAG MEGRDTHRLP RAL

References

[1]

Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N., Rajkumar N., Willa H.T., Daniels M., Downing T.K., Stanaway I.B., Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J., Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ011222 Genomic DNA. Translation: AAY16985.1.
IPI	IPI00289572.
3D structure databases
ProteinModelPortal	A0M8X1.
ModBase	Search...
Protein-protein interaction databases
IntAct	A0M8X1. 1 interaction.
Protein family/group databases
Allergome	9554. Hom s TPO.
PeroxiBase	3318. HsTPO01.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000071.
Family and domain databases
Gene3D	1.10.640.10. 2 hits.
InterPro	IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR010255. Haem_peroxidase. IPR002007. Haem_peroxidase_animal. IPR019791. Haem_peroxidase_animal_subgr. IPR000436. Sushi_SCR_CCP. [Graphical view]
Pfam	PF03098. An_peroxidase. 1 hit. PF07645. EGF_CA. 1 hit. [Graphical view]
PRINTS	PR00457. ANPEROXIDASE.
SMART	SM00032. CCP. 1 hit. SM00179. EGF_CA. 1 hit. [Graphical view]
SUPFAM	SSF57535. Complement_control_module. 1 hit. SSF48113. Peroxidase_super. 1 hit.
PROSITE	PS00010. ASX_HYDROXYL. 1 hit. PS01186. EGF_2. 1 hit. PS50026. EGF_3. 1 hit. PS01187. EGF_CA. 1 hit. PS50292. PEROXIDASE_3. 1 hit. PS50923. SUSHI. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TPO. human.
NextBio	35459962.

Entry information

Entry name

A0M8X1_HUMAN

Accession

Primary (citable) accession number: A0M8X1

Entry history

Integrated into UniProtKB/TrEMBL:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.