Unreviewed, UniProtKB/TrEMBL A0M8W7 (A0M8W7_HUMAN)

Names and origin

Protein names

Submitted name:
    Beta-site APP-cleaving enzyme 1 EMBL AAY16982.1
Submitted name:
    Beta-site APP-cleaving enzyme 1, isoform CRA_d EMBL EAW67313.1

Gene names

Name:	BACE1 EMBL AAY16982.1
ORF Names:	hCG_37942 EMBL EAW67313.1

Organism

Homo sapiens (Human) EMBL AAY16982.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Sequence similarities

Belongs to the peptidase A1 family. RuleBase RU000454V1

Ontologies

Keywords
Molecular function	Aspartyl protease RuleBase RU000454V1 Hydrolase Protease
Gene Ontology (GO)
Uncategorized	aspartic-type signal peptidase activity Inferred from electronic annotation. Source: InterPro pepsin A activity Inferred from electronic annotation. Source: InterPro
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	aspartic-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0M8W7-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 377CE4C824ACEF05	FASTA	501	55,764
	10 20 30 40 50 60 MAQALPWLLL WMGAGVLPAH GTQHGIRLPL RSGLGGAPLG LRLPRETDEE PEEPGRRGSF 70 80 90 100 110 120 VEMVDNLRGK SGQGYYVEMT VGSPPQTLNI LVDTGSSNFA VGAAPHPFLH RYYQRQLSST 130 140 150 160 170 180 YRDLRKGVYV PYTQGKWEGE LGTDLVSIPH GPNVTVRANI AAITESDKFF INGSNWEGIL 190 200 210 220 230 240 GLAYAEIARP DDSLEPFFDS LVKQTHVPNL FSLQLCGAGF PLNQSEVLAS VGGSMIIGGI 250 260 270 280 290 300 DHSLYTGSLW YTPIRREWYY EVIIVRVEIN GQDLKMDCKE YNYDKSIVDS GTTNLRLPKK 310 320 330 340 350 360 VFEAAVKSIK AASSTEKFPD GFWLGEQLVC WQAGTTPWNI FPVISLYLMG EVTNQSFRIT 370 380 390 400 410 420 ILPQQYLRPV EDVATSQDDC YKFAISQSST GTVMGAVIME GFYVVFDRAR KRIGFAVSAC 430 440 450 460 470 480 HVHDEFRTAA VEGPFVTLDM EDCGYNIPQT DESTLMTIAY VMAAICALFM LPLCLMVCQW 490 500 RCLRCLRQQH DDFADDISLL K

References

[1]	Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N., Rajkumar N., Willa H.T., Daniels M., Downing T.K., Stanaway I.B., Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J., Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ007053 Genomic DNA. Translation: AAY16982.1. CH471065 Genomic DNA. Translation: EAW67313.1.
IPI	IPI00011518.
RefSeq	NP_036236.1.
UniGene	Hs.504003
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	A0M8W7.
Genome annotation databases
Ensembl	ENSG00000186318. Homo sapiens. [Contig view]
GeneID	23621.
KEGG	hsa:23621.
Organism-specific databases
HGNC	HGNC:933. BACE1.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	A0M8W7.
Gene expression databases
Bgee	A0M8W7.
Family and domain databases
InterPro	IPR009119. Pept_A1_BACE. IPR009120. Pept_A1_BACE1. IPR001461. Peptidase_A1. IPR001969. Peptidase_aspartic_AS. [Graphical view]
PANTHER	PTHR13683. Peptidase_A1. 1 hit.
Pfam	PF00026. Asp. 1 hit. [Graphical view]
PRINTS	PR01816. BACE1. PR01815. BACEFAMILY. PR00792. PEPSIN.
PROSITE	PS00141. ASP_PROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	46358.

Entry information

Entry name

A0M8W7_HUMAN

Accession

Primary (citable) accession number: A0M8W7

Entry history

Integrated into UniProtKB/TrEMBL:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)