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A0M8T2

- WNT2_FELCA

UniProt

A0M8T2 - WNT2_FELCA

Protein

Protein Wnt-2

Gene

WNT2

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.By similarity

    GO - Biological processi

    1. atrial cardiac muscle tissue morphogenesis Source: Ensembl
    2. canonical Wnt signaling pathway Source: Ensembl
    3. cardiac epithelial to mesenchymal transition Source: Ensembl
    4. cellular response to transforming growth factor beta stimulus Source: Ensembl
    5. labyrinthine layer blood vessel development Source: Ensembl
    6. lung induction Source: Ensembl
    7. mammary gland epithelium development Source: Ensembl
    8. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    9. positive regulation of cardiac muscle cell proliferation Source: Ensembl
    10. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: Ensembl
    11. positive regulation of fibroblast proliferation Source: Ensembl
    12. positive regulation of mesenchymal cell proliferation Source: Ensembl
    13. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    14. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-2
    Gene namesi
    Name:WNT2
    OrganismiFelis catus (Cat) (Felis silvestris catus)
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
    ProteomesiUP000011712: Chromosome A2

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. plasma membrane Source: Ensembl
    3. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 360335Protein Wnt-2PRO_0000279198Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi76 ↔ 87By similarity
    Disulfide bondi127 ↔ 135By similarity
    Disulfide bondi137 ↔ 157By similarity
    Disulfide bondi206 ↔ 220By similarity
    Disulfide bondi208 ↔ 215By similarity
    Lipidationi212 – 2121O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi294 ↔ 309By similarity
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi324 ↔ 339By similarity
    Disulfide bondi326 ↔ 336By similarity
    Disulfide bondi331 ↔ 332By similarity

    Post-translational modificationi

    Palmitoylation at Ser-212 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Interactioni

    Protein-protein interaction databases

    STRINGi9685.ENSFCAP00000012292.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284879.
    GeneTreeiENSGT00740000115400.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    KOiK00182.
    OMAiWKKYNGA.
    OrthoDBiEOG7C8GJ8.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR009140. Wnt2.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01842. WNT2PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A0M8T2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNAPLGGIWP WLPLLLTWLT PEVSSSWWYM RATGGSSRVM CDNVPGLVSR    50
    QRQLCHRHPD VMRAIGLGVA EWTAECQHQF RQHRWNCNTL DRDHSLFGRV 100
    LLRSSRESAF VYAVSSAGVV FAITRACSQG ELKSCSCDPK KKGTAKDSKG 150
    NFDWGGCSDN IDYGIKFARA FVDAKERKGK DARALMNLHN NRAGRKAVKR 200
    FLKQECKCHG VSGSCTLRTC WLAMADFRKT GDYLWRKYNG AIQVVMNQDG 250
    TGFTVANKRF KKPTKNDLVY FENSPDYCIR DRDAGSLGTA GRVCNLTSRG 300
    MDSCEVMCCG RGYDTSHVTR MTKCECKFHW CCAVRCQDCL EALDVHTCKA 350
    PKSVDWAAPT 360
    Length:360
    Mass (Da):40,435
    Last modified:December 12, 2006 - v1
    Checksum:i095FBC550AB024AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000234 Genomic DNA. Translation: AAR16235.1.
    RefSeqiNP_001162170.1. NM_001168699.1.

    Genome annotation databases

    EnsembliENSFCAT00000013259; ENSFCAP00000012292; ENSFCAG00000013255.
    GeneIDi493672.
    KEGGifca:493672.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DP000234 Genomic DNA. Translation: AAR16235.1 .
    RefSeqi NP_001162170.1. NM_001168699.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9685.ENSFCAP00000012292.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSFCAT00000013259 ; ENSFCAP00000012292 ; ENSFCAG00000013255 .
    GeneIDi 493672.
    KEGGi fca:493672.

    Organism-specific databases

    CTDi 7472.

    Phylogenomic databases

    eggNOGi NOG284879.
    GeneTreei ENSGT00740000115400.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    KOi K00182.
    OMAi WKKYNGA.
    OrthoDBi EOG7C8GJ8.
    TreeFami TF105310.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR009140. Wnt2.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01842. WNT2PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analyses of multi-species sequences from targeted genomic regions."
      Thomas J.W., Touchman J.W., Blakesley R.W., Bouffard G.G., Beckstrom-Sternberg S.M., Margulies E.H., Blanchette M., Siepel A.C., Thomas P.J., McDowell J.C., Maskeri B., Hansen N.F., Schwartz M.S., Weber R.J., Kent W.J., Karolchik D., Bruen T.C., Bevan R.
      , Cutler D.J., Schwartz S., Elnitski L., Idol J.R., Prasad A.B., Lee-Lin S.-Q., Maduro V.V.B., Summers T.J., Portnoy M.E., Dietrich N.L., Akhter N., Ayele K., Benjamin B., Cariaga K., Brinkley C.P., Brooks S.Y., Granite S., Guan X., Gupta J., Haghighi P., Ho S.-L., Huang M.C., Karlins E., Laric P.L., Legaspi R., Lim M.J., Maduro Q.L., Masiello C.A., Mastrian S.D., McCloskey J.C., Pearson R., Stantripop S., Tiongson E.E., Tran J.T., Tsurgeon C., Vogt J.L., Walker M.A., Wetherby K.D., Wiggins L.S., Young A.C., Zhang L.-H., Osoegawa K., Zhu B., Zhao B., Shu C.L., De Jong P.J., Lawrence C.E., Smit A.F., Chakravarti A., Haussler D., Green P., Miller W., Green E.D.
      Nature 424:788-793(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiWNT2_FELCA
    AccessioniPrimary (citable) accession number: A0M8T2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3