Reviewed, UniProtKB/Swiss-Prot A0M764 (F16A2_GRAFK)

Names and origin

Protein names

Recommended name:
    Fructose-1,6-bisphosphatase class 1 2
      Short name=FBPase class 1 2
    EC=3.1.3.11
Alternative name(s):
    D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 2

Gene names

Name:	fbp2
Ordered Locus Names:	GFO_3521

Organism

Gramella forsetii (strain KT0803) [Complete proteome] [HAMAP]

Taxonomic identifier

411154 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Flavobacteria › Flavobacteriales › Flavobacteriaceae › Gramella

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the FBPase class 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	fructose 1,6-bisphosphate 1-phosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Fructose-1,6-bisphosphatase class 1 2 HAMAP MF_01855		PRO_0000364564
Regions
	Region	120 – 123	4	Substrate binding By similarity
Sites
	Metal binding	93	1	Magnesium 1 By similarity
	Metal binding	117	1	Magnesium 1 By similarity
	Metal binding	117	1	Magnesium 2 By similarity
	Metal binding	119	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	120	1	Magnesium 2 By similarity
	Metal binding	280	1	Magnesium 2 By similarity
	Binding site	213	1	Substrate By similarity
	Binding site	244	1	Substrate By similarity
	Binding site	274	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0M764-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: F02AE711AEF6AA0D	FASTA	348	38,767
	10 20 30 40 50 60 MSKPNQTLGE FIIENQSDFP GSSGELSRLI NSLRLAAKVV NHEVNKAGLV DIIGAYGETN 70 80 90 100 110 120 VQGEDQQKLD VYANNKFIQT LTNREIVCGI ASEENDDFIQ IEGHKGDHQN KYVVLMDPLD 130 140 150 160 170 180 GSSNIDVNVS VGTIFSIYQR VTPVGTPVQK EDFLQPGNKQ VAAGYIIYGT STMLVYTTGH 190 200 210 220 230 240 GVNGFTLNPA LGSWYLSHPD MKFPEEGQIY SINEGNYIHF PQGVKDYIKY CQQEEGNRPY 250 260 270 280 290 300 TSRYIGSMVS DIHRNMIKGG IFMYPKSSKA SEGKLRLLYE CNPFAFITEQ AGGKASDGFQ 310 320 330 340 RIMDIDPTEL HQRVPFFCGS KKMVEKAEEF MANAKANPQS QEFSFSSK

References

[1]

"Whole genome analysis of the marine Bacteroidetes'Gramella forsetii' reveals adaptations to degradation of polymeric organic matter." Bauer M., Kube M., Teeling H., Richter M., Lombardot T., Allers E., Wuerdemann C.A., Quast C., Kuhl H., Knaust F., Woebken D., Bischof K., Mussmann M., Choudhuri J.V., Meyer F., Reinhardt R., Amann R.I., Gloeckner F.O. Environ. Microbiol. 8:2201-2213(2006) [PubMed: 17107561] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CU207366 Genomic DNA. Translation: CAL68459.1.
RefSeq	YP_863526.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0M764.
Genome annotation databases
GeneID	4651540.
GenomeReviews	Gene locus GFO_3521 in contig CU207366_GR.
KEGG	gfo:GFO_3521.
NMPDR	fig|411154.5.peg.3323.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	QRHWEAP.
Family and domain databases
HAMAP	MF_01855. [Tree]
InterPro	IPR000146. Fructose_bisphosphatase. IPR020548. Fructose_bisphosphatase_AS. [Graphical view]
PANTHER	PTHR11556. In_FB_phphtase. 1 hit.
Pfam	PF00316. FBPase. 1 hit. [Graphical view]
PRINTS	PR00115. F16BPHPHTASE.
ProDom	PD001491. In_FB_phphtase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00124. FBPASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F16A2_GRAFK

Accession

Primary (citable) accession number: A0M764

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	December 12, 2006
Last modified:	November 3, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)