A0M6P8 (A0M6P8_GRAFK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Large-conductance mechanosensitive channel 2 HAMAP MF_00115

Gene names

Name:	mscL EMBL CAL68293.1
Synonyms:	mscL2 HAMAP MF_00115
Ordered Locus Names:	GFO_3352

Organism

Gramella forsetii (strain KT0803) [Complete proteome] [HAMAP]

Taxonomic identifier

411154 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Gramella

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. HAMAP MF_00115
Subunit structure	Homopentamer By similarity. HAMAP MF_00115
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00115.
Sequence similarities	Belongs to the MscL family. HAMAP MF_00115

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell inner membrane HAMAP MF_00115 Cell membrane Membrane
Domain	Transmembrane Transmembrane helix HAMAP MF_00115 SAAS SAAS001185
Molecular function	Ionic channel HAMAP MF_00115 SAAS SAAS001185
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Transmembrane	9 – 29	21	Helical; By similarity HAMAP MF_00115
	Transmembrane	32 – 52	21	Helical; By similarity HAMAP MF_00115
	Transmembrane	83 – 103	21	Helical; By similarity HAMAP MF_00115

Sequences

	Sequence		Length	Mass (Da)
	A0M6P8 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: ED3143779312A4C6	FASTA	142	15,796
	10 20 30 40 50 60 MAFFKDFKTF LFKKDIIMLA TAVVIGAAFN KIVSSVVDDI IMPIIGIITG GVDFSQKYIA 70 80 90 100 110 120 LDGRQYENLE AAKAAEAAVL TYGNLIQAII YFIIIGLFIF LVLRAYEKTK QKEDVEGADA 130 140 PKGPTQEQIL LEIRDELKKQ NS

References

[1]

"Whole genome analysis of the marine Bacteroidetes'Gramella forsetii' reveals adaptations to degradation of polymeric organic matter." Bauer M., Kube M., Teeling H., Richter M., Lombardot T., Allers E., Wuerdemann C.A., Quast C., Kuhl H., Knaust F., Woebken D., Bischof K., Mussmann M., Choudhuri J.V., Meyer F., Reinhardt R., Amann R.I., Gloeckner F.O. Environ. Microbiol. 8:2201-2213(2006) [PubMed: 17107561] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU207366 Genomic DNA. Translation: CAL68293.1.
RefSeq	YP_863360.1. NC_008571.1.
3D structure databases
ProteinModelPortal	A0M6P8.
ModBase	Search...
Protein-protein interaction databases
STRING	A0M6P8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4652291.
GenomeReviews	Gene locus GFO_3352 in contig CU207366_GR.
KEGG	gfo:GFO_3352.
NMPDR	fig|411154.5.peg.3163.
PATRIC	22075436. VBIGraFor5527_3231.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1970.
HOGENOM	HBG727604.
OMA	VIDFVIV.
ProtClustDB	CLSK851869.
Family and domain databases
HAMAP	MF_00115. MscL. [Tree]
InterPro	IPR001185. MS_channel. [Graphical view]
KO	K03282.
Pfam	PF01741. MscL. 1 hit. [Graphical view]
SUPFAM	SSF81330. MS_channel. 1 hit.
TIGRFAMs	TIGR00220. MscL. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0M6P8_GRAFK

Accession

Primary (citable) accession number: A0M6P8

Entry history

Integrated into UniProtKB/TrEMBL:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)