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A0M679 (A0M679_GRAFK) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lipoprotein signal peptidase 2 HAMAP MF_00161
EC=3.4.23.36 HAMAP MF_00161
Alternative name(s):
Prolipoprotein signal peptidase 2 HAMAP MF_00161
Signal peptidase II 2 HAMAP MF_00161
Gene names
Name:lspA EMBL CAL68124.1
Synonyms:lspA2 HAMAP MF_00161
Ordered Locus Names:GFO_3180
OrganismGramella forsetii (strain KT0803) [Complete proteome] [HAMAP]
Taxonomic identifier411154 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Gramella

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins By similarity. HAMAP MF_00161 SAAS SAAS001872

Catalytic activity

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains. HAMAP MF_00161 SAAS SAAS001872

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage). HAMAP MF_00161 SAAS SAAS001872

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00161.

Sequence similarities

Belongs to the peptidase A8 family. HAMAP MF_00161 RuleBase RU004181

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Transmembrane6 – 2621Helical; By similarity HAMAP MF_00161
Transmembrane64 – 8421Helical; By similarity HAMAP MF_00161
Transmembrane91 – 11121Helical; By similarity HAMAP MF_00161
Transmembrane169 – 18921Helical; By similarity HAMAP MF_00161

Sites

Active site1091 By similarity HAMAP MF_00161
Active site1781 By similarity HAMAP MF_00161

Sequences

Sequence LengthMass (Da)Tools
A0M679 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 6D67CEF3144FA3D1

FASTA20322,841
        10         20         30         40         50         60 
MSLKKAGFFI ILILLIDQIS KLYIKTHFAL GDEVEVFDWF SILFVENEGM AWGTKIPGEY 

        70         80         90        100        110        120 
GKLALTLFRL AAIVGIGYWL WDAVRNNGSK ILIFSIALIF AGAFGNIIDS VFYGIIFDDS 

       130        140        150        160        170        180 
YGHVASFLPE AGGYSSLFHG KVVDMLYFPL WKGYLPEWIP IWGGEYFTFF EPVFNIADSA 

       190        200 
ISVGVAMLLV FNKRAFPKED KAE

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References

[1]"Whole genome analysis of the marine Bacteroidetes'Gramella forsetii' reveals adaptations to degradation of polymeric organic matter."
Bauer M., Kube M., Teeling H., Richter M., Lombardot T., Allers E., Wuerdemann C.A., Quast C., Kuhl H., Knaust F., Woebken D., Bischof K., Mussmann M., Choudhuri J.V., Meyer F., Reinhardt R., Amann R.I., Gloeckner F.O.
Environ. Microbiol. 8:2201-2213(2006) [PubMed: 17107561] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU207366 Genomic DNA. Translation: CAL68124.1.
RefSeqYP_863191.1. NC_008571.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA0M679.

Protein family/group databases

MEROPSA08.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4651277.
GenomeReviewsGene locus GFO_3180 in contig CU207366_GR.
KEGGgfo:GFO_3180.
NMPDRfig|411154.5.peg.2996.
PATRIC22075094. VBIGraFor5527_3063.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG78647.
HOGENOMHBG724422.
OMAHGKVVDM.
ProtClustDBPRK14788.

Family and domain databases

HAMAPMF_00161. LspA.
[Tree]
InterProIPR001872. Peptidase_A8.
[Graphical view]
KOK03101.
PfamPF01252. Peptidase_A8. 1 hit.
[Graphical view]
PRINTSPR00781. LIPOSIGPTASE.
ProtoNetSearch...

Entry information

Entry nameA0M679_GRAFK
AccessionPrimary (citable) accession number: A0M679
Entry history
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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