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A0M5T6

- UPPP_GRAFK

UniProt

A0M5T6 - UPPP_GRAFK

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Gramella forsetii (strain KT0803)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciGFOR411154:GI79-3037-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:GFO_3037
    OrganismiGramella forsetii (strain KT0803)
    Taxonomic identifieri411154 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeGramella
    ProteomesiUP000000755: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 264264Undecaprenyl-diphosphatasePRO_0000290712Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi411154.GFO_3037.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221HelicalUniRule annotationAdd
    BLAST
    Transmembranei82 – 10221HelicalUniRule annotationAdd
    BLAST
    Transmembranei109 – 12921HelicalUniRule annotationAdd
    BLAST
    Transmembranei146 – 16621HelicalUniRule annotationAdd
    BLAST
    Transmembranei184 – 20421HelicalUniRule annotationAdd
    BLAST
    Transmembranei215 – 23521HelicalUniRule annotationAdd
    BLAST
    Transmembranei243 – 26321HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiNANEAVD.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0M5T6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDIFDAIVLG IIQGLTEFLP VSSSGHLELG KAILGDTSLP EESLLFTVVL    50
    HFATALSTLV VFRKDVFEIF SGLLKFKWNE ETQFSLKIII SMLPAVIVGL 100
    LFEEQLEALF GGNILFVGFM LLITALLLWL ADKAKDTGKK VSYRNAFIIG 150
    VSQAIAMLPG ISRSGATIST SVLLGNDKTK AARFSFLMVV PLIFGKIAKD 200
    LMSGELMASS TDFSILATGF IAAFLAGLVA CTWMISLVKK SKLSWFAIYC 250
    FVVGLAAIIF AYAQ 264
    Length:264
    Mass (Da):28,599
    Last modified:December 12, 2006 - v1
    Checksum:iE63483089CEDC262
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU207366 Genomic DNA. Translation: CAL67981.1.
    RefSeqiYP_863048.1. NC_008571.1.

    Genome annotation databases

    EnsemblBacteriaiCAL67981; CAL67981; GFO_3037.
    GeneIDi4651146.
    KEGGigfo:GFO_3037.
    PATRICi22074818. VBIGraFor5527_2925.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU207366 Genomic DNA. Translation: CAL67981.1 .
    RefSeqi YP_863048.1. NC_008571.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 411154.GFO_3037.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL67981 ; CAL67981 ; GFO_3037 .
    GeneIDi 4651146.
    KEGGi gfo:GFO_3037.
    PATRICi 22074818. VBIGraFor5527_2925.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi NANEAVD.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci GFOR411154:GI79-3037-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome analysis of the marine Bacteroidetes'Gramella forsetii' reveals adaptations to degradation of polymeric organic matter."
      Bauer M., Kube M., Teeling H., Richter M., Lombardot T., Allers E., Wuerdemann C.A., Quast C., Kuhl H., Knaust F., Woebken D., Bischof K., Mussmann M., Choudhuri J.V., Meyer F., Reinhardt R., Amann R.I., Gloeckner F.O.
      Environ. Microbiol. 8:2201-2213(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KT0803.

    Entry informationi

    Entry nameiUPPP_GRAFK
    AccessioniPrimary (citable) accession number: A0M5T6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3