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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Gramella forsetii (strain KT0803)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei740ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGFOR411154:G1GJG-2888-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:GFO_3032
OrganismiGramella forsetii (strain KT0803)
Taxonomic identifieri411154 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeGramella
Proteomesi
  • UP000000755 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000093471 – 962Leucine--tRNA ligaseAdd BLAST962

Proteomic databases

PRIDEiA0M5T1

Interactioni

Protein-protein interaction databases

STRINGi411154.GFO_3032

Structurei

3D structure databases

ProteinModelPortaliA0M5T1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi737 – 741"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 3 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 3 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A0M5T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYHFNKIEE KWQKYWADNQ TFKASNDSEK PKYYVLDMFP YPSGAGLHVG
60 70 80 90 100
HPLGYIASDI YARFKRHKGF NVLHPQGYDS FGLPAEQYAI QTGQHPAVTT
110 120 130 140 150
ENNIARYREQ LDKIGFSFDW SREVRTSEPD YYKWTQWIFI QLFESWYDQE
160 170 180 190 200
AEKSRAITEL EEIFTSEGNS RINAASDDDV EKFSADDWNA CSEDEKEQIL
210 220 230 240 250
LKYRLTYLAE AEVNWCPQLG TVLANDEIVN GVSERGGYPV VRKKMTQWSM
260 270 280 290 300
RISAFSERLL QDLNKIDWTE SLKESQRNWI GKSVGAHVDF KIENSKFKIG
310 320 330 340 350
VFTTRPDTIF GVSFMTLAPE HELVEKITTE DRKEEVQAYI EASAKRSERE
360 370 380 390 400
RMADVKTISG AFTGAYAEHP FTKKPVPIWI GDYVLAGYGT GAVMAVPCGD
410 420 430 440 450
QRDHDFARHF DLLIPNIFEN VDVSQEAYAG KEGTVIANSD FLSGLEYKEA
460 470 480 490 500
LNKVILELEK TGQGYGKTNY RLRDAVFSRQ RYWGEPFPVY YVNGLPKMID
510 520 530 540 550
EKYLPLKLPE VEKYLPTETG EPPLGNATDW AWDSKNNKVV SNKVLKQSRK
560 570 580 590 600
LSGQHDEPNS NVTPSAVEGS DDNGIYPLEL NTMPGWAGSS WYLFRYMGAG
610 620 630 640 650
NPDRFVSEEA QKYWENVDLY IGGSEHATGH LLYSRFWTKF LYDRGWLTVE
660 670 680 690 700
EPFKKLINQG MILGTSAFVY RLEGENVFVS KNQINGNNVQ PIHADVSLVN
710 720 730 740 750
SSDELDIEGF KKWRPEFADA KFLTEDGKYI VGREVEKMSK SKYNVVNPDE
760 770 780 790 800
ICQDYGADTL RMYEMFLGPL EQAKPWNTAG ITGVHNFLKK LWKLYYDGEE
810 820 830 840 850
FFVSDEKASA DSLKTFHKTI KKVTEDIEEF SFNTSVSTFM ICVNELTAQK
860 870 880 890 900
CNSREILEPL AVLIAPYAPH IAEELWEKLG NSESVTTAKY PEFEEKYLVE
910 920 930 940 950
SMKNYPVSFN GKMRFTMELS LDMSKEEIEK TVMADERTQK QLDGRTPKKV
960
IVVPGKIVNI VG
Length:962
Mass (Da):110,237
Last modified:December 12, 2006 - v1
Checksum:iF535EE086A219AC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207366 Genomic DNA Translation: CAL67976.1
RefSeqiWP_011710877.1, NC_008571.1

Genome annotation databases

EnsemblBacteriaiCAL67976; CAL67976; GFO_3032
KEGGigfo:GFO_3032

Similar proteinsi

Entry informationi

Entry nameiSYL_GRAFK
AccessioniPrimary (citable) accession number: A0M5T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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