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A0M5T1

- SYL_GRAFK

UniProt

A0M5T1 - SYL_GRAFK

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Gramella forsetii (strain KT0803)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei740 – 7401ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGFOR411154:GI79-3032-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:GFO_3032
    OrganismiGramella forsetii (strain KT0803)
    Taxonomic identifieri411154 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeGramella
    ProteomesiUP000000755: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 962962Leucine--tRNA ligasePRO_1000009347Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi411154.GFO_3032.

    Structurei

    3D structure databases

    ProteinModelPortaliA0M5T1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi737 – 7415"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiDKPKYYA.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 5 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0M5T1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYHFNKIEE KWQKYWADNQ TFKASNDSEK PKYYVLDMFP YPSGAGLHVG    50
    HPLGYIASDI YARFKRHKGF NVLHPQGYDS FGLPAEQYAI QTGQHPAVTT 100
    ENNIARYREQ LDKIGFSFDW SREVRTSEPD YYKWTQWIFI QLFESWYDQE 150
    AEKSRAITEL EEIFTSEGNS RINAASDDDV EKFSADDWNA CSEDEKEQIL 200
    LKYRLTYLAE AEVNWCPQLG TVLANDEIVN GVSERGGYPV VRKKMTQWSM 250
    RISAFSERLL QDLNKIDWTE SLKESQRNWI GKSVGAHVDF KIENSKFKIG 300
    VFTTRPDTIF GVSFMTLAPE HELVEKITTE DRKEEVQAYI EASAKRSERE 350
    RMADVKTISG AFTGAYAEHP FTKKPVPIWI GDYVLAGYGT GAVMAVPCGD 400
    QRDHDFARHF DLLIPNIFEN VDVSQEAYAG KEGTVIANSD FLSGLEYKEA 450
    LNKVILELEK TGQGYGKTNY RLRDAVFSRQ RYWGEPFPVY YVNGLPKMID 500
    EKYLPLKLPE VEKYLPTETG EPPLGNATDW AWDSKNNKVV SNKVLKQSRK 550
    LSGQHDEPNS NVTPSAVEGS DDNGIYPLEL NTMPGWAGSS WYLFRYMGAG 600
    NPDRFVSEEA QKYWENVDLY IGGSEHATGH LLYSRFWTKF LYDRGWLTVE 650
    EPFKKLINQG MILGTSAFVY RLEGENVFVS KNQINGNNVQ PIHADVSLVN 700
    SSDELDIEGF KKWRPEFADA KFLTEDGKYI VGREVEKMSK SKYNVVNPDE 750
    ICQDYGADTL RMYEMFLGPL EQAKPWNTAG ITGVHNFLKK LWKLYYDGEE 800
    FFVSDEKASA DSLKTFHKTI KKVTEDIEEF SFNTSVSTFM ICVNELTAQK 850
    CNSREILEPL AVLIAPYAPH IAEELWEKLG NSESVTTAKY PEFEEKYLVE 900
    SMKNYPVSFN GKMRFTMELS LDMSKEEIEK TVMADERTQK QLDGRTPKKV 950
    IVVPGKIVNI VG 962
    Length:962
    Mass (Da):110,237
    Last modified:December 12, 2006 - v1
    Checksum:iF535EE086A219AC2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU207366 Genomic DNA. Translation: CAL67976.1.
    RefSeqiWP_011710877.1. NC_008571.1.
    YP_863043.1. NC_008571.1.

    Genome annotation databases

    EnsemblBacteriaiCAL67976; CAL67976; GFO_3032.
    GeneIDi4652867.
    KEGGigfo:GFO_3032.
    PATRICi22074808. VBIGraFor5527_2920.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU207366 Genomic DNA. Translation: CAL67976.1 .
    RefSeqi WP_011710877.1. NC_008571.1.
    YP_863043.1. NC_008571.1.

    3D structure databases

    ProteinModelPortali A0M5T1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 411154.GFO_3032.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL67976 ; CAL67976 ; GFO_3032 .
    GeneIDi 4652867.
    KEGGi gfo:GFO_3032.
    PATRICi 22074808. VBIGraFor5527_2920.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi DKPKYYA.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci GFOR411154:GI79-3032-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 5 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome analysis of the marine Bacteroidetes'Gramella forsetii' reveals adaptations to degradation of polymeric organic matter."
      Bauer M., Kube M., Teeling H., Richter M., Lombardot T., Allers E., Wuerdemann C.A., Quast C., Kuhl H., Knaust F., Woebken D., Bischof K., Mussmann M., Choudhuri J.V., Meyer F., Reinhardt R., Amann R.I., Gloeckner F.O.
      Environ. Microbiol. 8:2201-2213(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KT0803.

    Entry informationi

    Entry nameiSYL_GRAFK
    AccessioniPrimary (citable) accession number: A0M5T1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3