A0M5L8 (A0M5L8_GRAFK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid-A-disaccharide synthase EMBL CAL67913.1
EC=2.4.1.182 EMBL CAL67913.1

Gene names

Name:	lpxB EMBL CAL67913.1
Ordered Locus Names:	GFO_2966

Organism

Gramella forsetii (strain KT0803) [Complete proteome] [HAMAP]

Taxonomic identifier

411154 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Gramella

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 EMBL CAL67913.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0M5L8 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: C95E1816C21784BC	FASTA	370	42,990
	10 20 30 40 50 60 MKYYIIAGEA SGDLHASNLM KALKEVDTDA NFRFWGGDLM ENQGGKLVKH YKELAFMGFS 70 80 90 100 110 120 EVIMNLRTIF RNIKFCKQDI ESYNPDVIIF VDYPGFNMRI AEWAKKKGYR TSYYISPQIW 130 140 150 160 170 180 AWKENRIKKI KRDVDEMYVI LPFEKDFYTE KHNFPVHFVG HPLLDAIDNR PLVDIKLFKK 190 200 210 220 230 240 NNGLDNRPII ALLPGSRKQE IEKMLNVMLS ITSEFKDYQF VIAGAPSQDK EFYRGFIKKS 250 260 270 280 290 300 NISIIKNKTY DVLSISHAAL VTSGTATLET ALFKVPEVVC YKGSYISYHI AKRIINLDYI 310 320 330 340 350 360 SLVNLIMDRE VVTELIQNEF NTKNLKTELT KILNEENRKR IFEDYFELEQ KLGGKGASKK 370 TAELIYNNIK

References

[1]

"Whole genome analysis of the marine Bacteroidetes'Gramella forsetii' reveals adaptations to degradation of polymeric organic matter." Bauer M., Kube M., Teeling H., Richter M., Lombardot T., Allers E., Wuerdemann C.A., Quast C., Kuhl H., Knaust F., Woebken D., Bischof K., Mussmann M., Choudhuri J.V., Meyer F., Reinhardt R., Amann R.I., Gloeckner F.O. Environ. Microbiol. 8:2201-2213(2006) [PubMed: 17107561] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU207366 Genomic DNA. Translation: CAL67913.1.
RefSeq	YP_862980.1. NC_008571.1.
3D structure databases
ProteinModelPortal	A0M5L8.
ModBase	Search...
Protein-protein interaction databases
STRING	A0M5L8.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4651088.
GenomeReviews	Gene locus GFO_2966 in contig CU207366_GR.
KEGG	gfo:GFO_2966.
NMPDR	fig|411154.5.peg.2799.
PATRIC	22074680. VBIGraFor5527_2859.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HBG584837.
OMA	IGLANIM.
PhylomeDB	A0M5L8.
ProtClustDB	CLSK823744.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0M5L8_GRAFK

Accession

Primary (citable) accession number: A0M5L8

Entry history

Integrated into UniProtKB/TrEMBL:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)