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A0M5D4 (GCSP_GRAFK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:GFO_2875
OrganismGramella forsetii (strain KT0803) [Complete proteome] [HAMAP]
Taxonomic identifier411154 [NCBI]
Taxonomic lineageBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeGramella

Protein attributes

Sequence length949 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 949949Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045584

Amino acid modifications

Modified residue7001N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A0M5D4 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 4C244DFB5570E1DB

FASTA949104,980
        10         20         30         40         50         60 
MRTDSFALRH IGPKAENLQE MLDTIGVESI EQLIYETIPD DIRLDQPLNL PKAMSENQYA 

        70         80         90        100        110        120 
EHIKKLSEKN RVFKTYIGLG YHQAILPAVI QRNILENPGW YTAYTPYQAE IAQGRLEALL 

       130        140        150        160        170        180 
NFQTMVSDLT GMEIANASLL DESTAAAEAM ALLHAVRDRK QKKDDVNKFF VSQQTLPQTI 

       190        200        210        220        230        240 
SLMETRANFL GIDMVVGDHE EFDFSEEYFG ALVQYPGKFG QIFDYANFVE NCKNANIKTA 

       250        260        270        280        290        300 
FAADILSLVK LQAPGELGVD VVVGTTQRFG IPLGYGGPHA AYFATKEEYK RNLPGRIIGL 

       310        320        330        340        350        360 
TKDLDGNNAL RMALQTREQH IKRDKATSNI CTAQVLLAVM AGMYAVYHGP KGLEYIANIV 

       370        380        390        400        410        420 
HASAVSLEDS LKELGFEQLN SAYFDTIHVK ANASKLKAIA EKHEINFFYP DAESACISIN 

       430        440        450        460        470        480 
ETTTTDDLNA VIAVFAELSE KKHAEIEELS ERTAIPKNLE RKTEFLTHEV FNLYHSETEL 

       490        500        510        520        530        540 
MRYIKKLERK DLSLNHSMIS LGSCTMKLNA ASEMLPLSNP QWGNMHPFAP VNQAEGYQTV 

       550        560        570        580        590        600 
LKELEHQLTE ITGFSATSLQ PNSGAQGEYA GLMVIRAYHE ANGEGHRNVC LIPSSAHGTN 

       610        620        630        640        650        660 
PASAVMAGMK VVVTKASENG NIDVDDLREK AIKHKDNLAA LMVTYPSTHG VFESAIREIT 

       670        680        690        700        710        720 
NIIHENGGQV YMDGANMNAQ VGLTNPGRIG ADVCHLNLHK TFAIPHGGGG PGVGPICVAE 

       730        740        750        760        770        780 
QLKPFLPGNP VIKTGGEKAI GAISSAPWGS SLVCLISYGY IKMLGTGGLQ QATEYAILNA 

       790        800        810        820        830        840 
NYIKARLNDH YKTLYSGERG RAAHEMIIDC RPFKEQGIEV TDIAKRLIDY GFHSPTVSFP 

       850        860        870        880        890        900 
VAGTMMIEPT ESESKPELDR FCDALISIRK EIDEVSVDDS NNVLKNAPHT IHMLTSDEWK 

       910        920        930        940 
LPYSREKAAY PLDHLHDNKF WPSVRRVDEA FGDRNLMCTC PPTEEYAEA 

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References

[1]"Whole genome analysis of the marine Bacteroidetes'Gramella forsetii' reveals adaptations to degradation of polymeric organic matter."
Bauer M., Kube M., Teeling H., Richter M., Lombardot T., Allers E., Wuerdemann C.A., Quast C., Kuhl H., Knaust F., Woebken D., Bischof K., Mussmann M., Choudhuri J.V., Meyer F., Reinhardt R., Amann R.I., Gloeckner F.O.
Environ. Microbiol. 8:2201-2213(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KT0803.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU207366 Genomic DNA. Translation: CAL67829.1.
RefSeqYP_862896.1. NC_008571.1.

3D structure databases

ProteinModelPortalA0M5D4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING411154.GFO_2875.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL67829; CAL67829; GFO_2875.
GeneID4651023.
KEGGgfo:GFO_2875.
PATRIC22074504. VBIGraFor5527_2778.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycGFOR411154:GI79-2875-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_GRAFK
AccessionPrimary (citable) accession number: A0M5D4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families