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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Gramella forsetii (strain KT0803)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciGFOR411154:GI79-2875-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:GFO_2875
OrganismiGramella forsetii (strain KT0803)
Taxonomic identifieri411154 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeGramella
ProteomesiUP000000755 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 949949Glycine dehydrogenase (decarboxylating)PRO_1000045584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei700 – 7001N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi411154.GFO_2875.

Structurei

3D structure databases

ProteinModelPortaliA0M5D4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A0M5D4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTDSFALRH IGPKAENLQE MLDTIGVESI EQLIYETIPD DIRLDQPLNL
60 70 80 90 100
PKAMSENQYA EHIKKLSEKN RVFKTYIGLG YHQAILPAVI QRNILENPGW
110 120 130 140 150
YTAYTPYQAE IAQGRLEALL NFQTMVSDLT GMEIANASLL DESTAAAEAM
160 170 180 190 200
ALLHAVRDRK QKKDDVNKFF VSQQTLPQTI SLMETRANFL GIDMVVGDHE
210 220 230 240 250
EFDFSEEYFG ALVQYPGKFG QIFDYANFVE NCKNANIKTA FAADILSLVK
260 270 280 290 300
LQAPGELGVD VVVGTTQRFG IPLGYGGPHA AYFATKEEYK RNLPGRIIGL
310 320 330 340 350
TKDLDGNNAL RMALQTREQH IKRDKATSNI CTAQVLLAVM AGMYAVYHGP
360 370 380 390 400
KGLEYIANIV HASAVSLEDS LKELGFEQLN SAYFDTIHVK ANASKLKAIA
410 420 430 440 450
EKHEINFFYP DAESACISIN ETTTTDDLNA VIAVFAELSE KKHAEIEELS
460 470 480 490 500
ERTAIPKNLE RKTEFLTHEV FNLYHSETEL MRYIKKLERK DLSLNHSMIS
510 520 530 540 550
LGSCTMKLNA ASEMLPLSNP QWGNMHPFAP VNQAEGYQTV LKELEHQLTE
560 570 580 590 600
ITGFSATSLQ PNSGAQGEYA GLMVIRAYHE ANGEGHRNVC LIPSSAHGTN
610 620 630 640 650
PASAVMAGMK VVVTKASENG NIDVDDLREK AIKHKDNLAA LMVTYPSTHG
660 670 680 690 700
VFESAIREIT NIIHENGGQV YMDGANMNAQ VGLTNPGRIG ADVCHLNLHK
710 720 730 740 750
TFAIPHGGGG PGVGPICVAE QLKPFLPGNP VIKTGGEKAI GAISSAPWGS
760 770 780 790 800
SLVCLISYGY IKMLGTGGLQ QATEYAILNA NYIKARLNDH YKTLYSGERG
810 820 830 840 850
RAAHEMIIDC RPFKEQGIEV TDIAKRLIDY GFHSPTVSFP VAGTMMIEPT
860 870 880 890 900
ESESKPELDR FCDALISIRK EIDEVSVDDS NNVLKNAPHT IHMLTSDEWK
910 920 930 940
LPYSREKAAY PLDHLHDNKF WPSVRRVDEA FGDRNLMCTC PPTEEYAEA
Length:949
Mass (Da):104,980
Last modified:December 12, 2006 - v1
Checksum:i4C244DFB5570E1DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207366 Genomic DNA. Translation: CAL67829.1.
RefSeqiWP_011710730.1. NC_008571.1.
YP_862896.1. NC_008571.1.

Genome annotation databases

EnsemblBacteriaiCAL67829; CAL67829; GFO_2875.
KEGGigfo:GFO_2875.
PATRICi22074504. VBIGraFor5527_2778.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207366 Genomic DNA. Translation: CAL67829.1.
RefSeqiWP_011710730.1. NC_008571.1.
YP_862896.1. NC_008571.1.

3D structure databases

ProteinModelPortaliA0M5D4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi411154.GFO_2875.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL67829; CAL67829; GFO_2875.
KEGGigfo:GFO_2875.
PATRICi22074504. VBIGraFor5527_2778.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciGFOR411154:GI79-2875-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Whole genome analysis of the marine Bacteroidetes'Gramella forsetii' reveals adaptations to degradation of polymeric organic matter."
    Bauer M., Kube M., Teeling H., Richter M., Lombardot T., Allers E., Wuerdemann C.A., Quast C., Kuhl H., Knaust F., Woebken D., Bischof K., Mussmann M., Choudhuri J.V., Meyer F., Reinhardt R., Amann R.I., Gloeckner F.O.
    Environ. Microbiol. 8:2201-2213(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KT0803.

Entry informationi

Entry nameiGCSP_GRAFK
AccessioniPrimary (citable) accession number: A0M5D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: April 29, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.