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A0M5D4

- GCSP_GRAFK

UniProt

A0M5D4 - GCSP_GRAFK

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Gramella forsetii (strain KT0803)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciGFOR411154:GI79-2875-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:GFO_2875
    OrganismiGramella forsetii (strain KT0803)
    Taxonomic identifieri411154 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeGramella
    ProteomesiUP000000755: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 949949Glycine dehydrogenase (decarboxylating)PRO_1000045584Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei700 – 7001N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi411154.GFO_2875.

    Structurei

    3D structure databases

    ProteinModelPortaliA0M5D4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0M5D4-1 [UniParc]FASTAAdd to Basket

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    MRTDSFALRH IGPKAENLQE MLDTIGVESI EQLIYETIPD DIRLDQPLNL    50
    PKAMSENQYA EHIKKLSEKN RVFKTYIGLG YHQAILPAVI QRNILENPGW 100
    YTAYTPYQAE IAQGRLEALL NFQTMVSDLT GMEIANASLL DESTAAAEAM 150
    ALLHAVRDRK QKKDDVNKFF VSQQTLPQTI SLMETRANFL GIDMVVGDHE 200
    EFDFSEEYFG ALVQYPGKFG QIFDYANFVE NCKNANIKTA FAADILSLVK 250
    LQAPGELGVD VVVGTTQRFG IPLGYGGPHA AYFATKEEYK RNLPGRIIGL 300
    TKDLDGNNAL RMALQTREQH IKRDKATSNI CTAQVLLAVM AGMYAVYHGP 350
    KGLEYIANIV HASAVSLEDS LKELGFEQLN SAYFDTIHVK ANASKLKAIA 400
    EKHEINFFYP DAESACISIN ETTTTDDLNA VIAVFAELSE KKHAEIEELS 450
    ERTAIPKNLE RKTEFLTHEV FNLYHSETEL MRYIKKLERK DLSLNHSMIS 500
    LGSCTMKLNA ASEMLPLSNP QWGNMHPFAP VNQAEGYQTV LKELEHQLTE 550
    ITGFSATSLQ PNSGAQGEYA GLMVIRAYHE ANGEGHRNVC LIPSSAHGTN 600
    PASAVMAGMK VVVTKASENG NIDVDDLREK AIKHKDNLAA LMVTYPSTHG 650
    VFESAIREIT NIIHENGGQV YMDGANMNAQ VGLTNPGRIG ADVCHLNLHK 700
    TFAIPHGGGG PGVGPICVAE QLKPFLPGNP VIKTGGEKAI GAISSAPWGS 750
    SLVCLISYGY IKMLGTGGLQ QATEYAILNA NYIKARLNDH YKTLYSGERG 800
    RAAHEMIIDC RPFKEQGIEV TDIAKRLIDY GFHSPTVSFP VAGTMMIEPT 850
    ESESKPELDR FCDALISIRK EIDEVSVDDS NNVLKNAPHT IHMLTSDEWK 900
    LPYSREKAAY PLDHLHDNKF WPSVRRVDEA FGDRNLMCTC PPTEEYAEA 949
    Length:949
    Mass (Da):104,980
    Last modified:December 12, 2006 - v1
    Checksum:i4C244DFB5570E1DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU207366 Genomic DNA. Translation: CAL67829.1.
    RefSeqiYP_862896.1. NC_008571.1.

    Genome annotation databases

    EnsemblBacteriaiCAL67829; CAL67829; GFO_2875.
    GeneIDi4651023.
    KEGGigfo:GFO_2875.
    PATRICi22074504. VBIGraFor5527_2778.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU207366 Genomic DNA. Translation: CAL67829.1 .
    RefSeqi YP_862896.1. NC_008571.1.

    3D structure databases

    ProteinModelPortali A0M5D4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 411154.GFO_2875.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL67829 ; CAL67829 ; GFO_2875 .
    GeneIDi 4651023.
    KEGGi gfo:GFO_2875.
    PATRICi 22074504. VBIGraFor5527_2778.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci GFOR411154:GI79-2875-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome analysis of the marine Bacteroidetes'Gramella forsetii' reveals adaptations to degradation of polymeric organic matter."
      Bauer M., Kube M., Teeling H., Richter M., Lombardot T., Allers E., Wuerdemann C.A., Quast C., Kuhl H., Knaust F., Woebken D., Bischof K., Mussmann M., Choudhuri J.V., Meyer F., Reinhardt R., Amann R.I., Gloeckner F.O.
      Environ. Microbiol. 8:2201-2213(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KT0803.

    Entry informationi

    Entry nameiGCSP_GRAFK
    AccessioniPrimary (citable) accession number: A0M5D4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3