A0M4X2 (KMO_GRAFK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine 3-monooxygenase
EC=1.14.13.9

Alternative name(s):
Kynurenine 3-hydroxylase

Gene names

Name:	kmo
Ordered Locus Names:	GFO_2711

Organism

Gramella forsetii (strain KT0803) [Complete proteome] [HAMAP]

Taxonomic identifier

411154 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Gramella

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
Sequence caution	The sequence CAL67667.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	kynurenine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 447	447	Kynurenine 3-monooxygenase		PRO_0000361938

Sequences

	Sequence		Length	Mass (Da)
	A0M4X2 [UniParc]. Last modified February 10, 2009. Version 2. Checksum: 950447EE85BBF1C8	FASTA	447	51,750
	10 20 30 40 50 60 MQKEKDVAIV GSGLVGSLLA IFLRKQGHKV TVFDRRPDVR NVQFSGRSIN LAMSNRGWKA 70 80 90 100 110 120 LREAGIEDEI RELALPLDKR AMHVEGQSVY FQKYGEEGEA IYSISRGILN RKMIDLAESA 130 140 150 160 170 180 GATFRFEEKI WDVDMKEARL YTGESEKSVW KEYQFDLIFG ADGAFSRVRH KMQRQSRFNY 190 200 210 220 230 240 SQHFIDVGYK ELTILANEDG SHKMDNSSFH IWPRGNFMLI AMPNLDGTFT CTLFMPFDGE 250 260 270 280 290 300 TSFESIKTED EADIFFEKYF PDIKDEISNL KKDFFKNPTS AMVTIKCFPW SYFDKITLVG 310 320 330 340 350 360 DSAHAIVPFY GQGMNAGFED ISVLNEKMNL YGDDWEKVFE DYQTERKPNA DAIAELSYRN 370 380 390 400 410 420 FVEMSKKTAD PKFLLRKKIE QKFAENHPDL WTPLYSRVTF SDKAYSDALK IGDYQREIMD 430 440 EVMKIPGIEE KWESSEVEEK IISLIKK

References

[1]

"Whole genome analysis of the marine Bacteroidetes'Gramella forsetii' reveals adaptations to degradation of polymeric organic matter." Bauer M., Kube M., Teeling H., Richter M., Lombardot T., Allers E., Wuerdemann C.A., Quast C., Kuhl H., Knaust F., Woebken D., Bischof K., Mussmann M., Choudhuri J.V., Meyer F., Reinhardt R., Amann R.I., Gloeckner F.O. Environ. Microbiol. 8:2201-2213(2006) [PubMed: 17107561] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KT0803.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU207366 Genomic DNA. Translation: CAL67667.1. Different initiation.
RefSeq	YP_862734.1. NC_008571.1.
3D structure databases
ProteinModelPortal	A0M4X2.
ModBase	Search...
Protein-protein interaction databases
STRING	A0M4X2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4652688.
GenomeReviews	Gene locus GFO_2711 in contig CU207366_GR.
KEGG	gfo:GFO_2711.
NMPDR	fig|411154.5.peg.2562.
PATRIC	22074176. VBIGraFor5527_2616.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0654.
HOGENOM	HBG430104.
ProtClustDB	CLSK903475.
Enzyme and pathway databases
BioCyc	GFOR411154:GFO_2711-MONOMER.
Family and domain databases
InterPro	IPR002938. mOase_FAD-bd. IPR003042. Rng_hydrolase-like. [Graphical view]
KO	K00486.
Pfam	PF01494. FAD_binding_3. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...

Entry information

Entry name

KMO_GRAFK

Accession

Primary (citable) accession number: A0M4X2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	December 14, 2011
This is version 36 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program