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Protein

Dihydrolipoyl dehydrogenase

Gene

lpd

Organism
Gramella forsetii (strain KT0803)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Name:lpdImported
Ordered Locus Names:GFO_2165Imported
OrganismiGramella forsetii (strain KT0803)Imported
Taxonomic identifieri411154 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeGramella
Proteomesi
  • UP000000755 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi411154.GFO_2165.

Structurei

3D structure databases

ProteinModelPortaliA0M3D5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 328FAD/NAD-binding_domInterPro annotationAdd BLAST325
Domaini347 – 456Pyr_redox_dimInterPro annotationAdd BLAST110

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiFLMDKNK.
OrthoDBiPOG091H0239.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0M3D5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTYDVAVIG SGPGGYVAAI RCAQLGMKTA IIEKYSTLGG TCLNVGCIPS
60 70 80 90 100
KALLDSSHHY DDAIKHFEDH GIEIPGEVKL NLEKMMERKS SVVSQTCDGV
110 120 130 140 150
KFLMDKNKID VIEGVGSFKD KTHINIEKDG ETQTIEAKKT IIATGSKPAN
160 170 180 190 200
LPFIELDKER VITSTEALTL KEVPKHMIVI GGGVIGLELG QVYRRLGAEV
210 220 230 240 250
TVVEFMDRII PTMDSALSKE LQKVLKKQGV KFHTSTKVKS VERNGDEITI
260 270 280 290 300
KADDKKDKEI ELKGDYCLVS VGRRPFTDGL NAEAAGVKLD DKGRVKVNDH
310 320 330 340 350
LQTNVENIYA IGDVVRGAML AHKAEEEGSM VAELMAGQKP HIDYNLIPGV
360 370 380 390 400
VYTWPEVASV GKTEEQLKEE GVKYKEGKFP MRALGRSRAS GDIDGLVKIL
410 420 430 440 450
ADEKTDEVLG VHMIGARTAD LIAEAVTAME FRASAEDIAR MSHAHPTYAE
460
AVKEAALAAT ENRALHI
Length:467
Mass (Da):50,839
Last modified:December 12, 2006 - v1
Checksum:i21169A874FF51F3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207366 Genomic DNA. Translation: CAL67130.1.
RefSeqiWP_011710033.1. NC_008571.1.

Genome annotation databases

EnsemblBacteriaiCAL67130; CAL67130; GFO_2165.
KEGGigfo:GFO_2165.
PATRICi22073101. VBIGraFor5527_2088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207366 Genomic DNA. Translation: CAL67130.1.
RefSeqiWP_011710033.1. NC_008571.1.

3D structure databases

ProteinModelPortaliA0M3D5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi411154.GFO_2165.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL67130; CAL67130; GFO_2165.
KEGGigfo:GFO_2165.
PATRICi22073101. VBIGraFor5527_2088.

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiFLMDKNK.
OrthoDBiPOG091H0239.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA0M3D5_GRAFK
AccessioniPrimary (citable) accession number: A0M3D5
Entry historyi
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.