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A0M380 (ILVC_GRAFK) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:GFO_2110
OrganismGramella forsetii (strain KT0803) [Complete proteome] [HAMAP]
Taxonomic identifier411154 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Gramella

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Ketol-acid reductoisomerase HAMAP MF_00435
PRO_1000190969

Sites

Active site1321 Potential

Sequences

Sequence LengthMass (Da)Tools
A0M380 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: FFB71F35DB1141A4

FASTA49155,002
        10         20         30         40         50         60 
MTNYFNSLSL RDQLAQLGTC RFMELDEFSN EVAVLKDKKI VIVGCGAQGL NQGLNMRDSG 

        70         80         90        100        110        120 
LDISYALREG AIKEKRQSWK NATENNFNVG TYEELIPKAD LVINLTPDKQ HTSVIKAIQP 

       130        140        150        160        170        180 
HIKKDAVLSY SHGFNIVEEG TKIREDITVI MVAPKCPGTE VREEYKRGFG VPTLIAVHPE 

       190        200        210        220        230        240 
NDPHGIGLDW AKAYAYATGG HRAGVLESSF VAEVKSDLMG EQTMLCGVLQ TGSILTFDKM 

       250        260        270        280        290        300 
VADGVEPNYA AKLIQYGWET ITEALKHGGI TNMMDRLSNP AKLRANEIAE ELKEKMRPLF 

       310        320        330        340        350        360 
QKHMDDIISG EFSSRMMRDW ANDDKELLTW RAETENTAFE KTEATSEEIK EQEYFDKGVL 

       370        380        390        400        410        420 
MVAFVRAGVE LAFETMVEAG IIEESAYYES LHETPLIANT IARKKLYEMN RVISDTAEYG 

       430        440        450        460        470        480 
CYLFDHAAKP LVKDYVNSLE PEVAGKKFGT DCNGVDNQKL IHVNDDLRSH PVEKVGARLR 

       490 
TAMTAMKKIY A

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References

[1]"Whole genome analysis of the marine Bacteroidetes'Gramella forsetii' reveals adaptations to degradation of polymeric organic matter."
Bauer M., Kube M., Teeling H., Richter M., Lombardot T., Allers E., Wuerdemann C.A., Quast C., Kuhl H., Knaust F., Woebken D., Bischof K., Mussmann M., Choudhuri J.V., Meyer F., Reinhardt R., Amann R.I., Gloeckner F.O.
Environ. Microbiol. 8:2201-2213(2006) [PubMed: 17107561] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KT0803.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU207366 Genomic DNA. Translation: CAL67075.1.
RefSeqYP_862142.1. NC_008571.1.

3D structure databases

ProteinModelPortalA0M380.
SMRA0M380. Positions 3-489.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0M380.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4652564.
GenomeReviewsGene locus GFO_2110 in contig CU207366_GR.
KEGGgfo:GFO_2110.
NMPDRfig|411154.5.peg.1999.
PATRIC22072995. VBIGraFor5527_2035.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0059.
HOGENOMHBG297205.
OMAEKHMDDI.
PhylomeDBA0M380.
ProtClustDBPRK05225.

Enzyme and pathway databases

BioCycGFOR411154:GFO_2110-MONOMER.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
IPR014359. KetolA_reductoisomerase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PTHR21371:SF2. PTHR21371:SF2. 1 hit.
PfamPF01450. IlvC. 2 hits.
PF07991. IlvN. 1 hit.
[Graphical view]
PIRSFPIRSF000116. IlvC_gammaproteo. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 2 hits.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_GRAFK
AccessionPrimary (citable) accession number: A0M380
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: December 12, 2006
Last modified: December 14, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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