A0M299 (A0M299_GRAFK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase EMBL CAL66744.1
EC=2.3.1.129 EMBL CAL66744.1

Gene names

Name:	lpxA EMBL CAL66744.1
Ordered Locus Names:	GFO_1774

Organism

Gramella forsetii (strain KT0803) [Complete proteome] [HAMAP]

Taxonomic identifier

411154 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Gramella

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS010137
Catalytic activity	(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. SAAS SAAS010137
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. SAAS SAAS010137
Subunit structure	Homotrimer By similarity. SAAS SAAS010137
Subcellular location	Cytoplasm By similarity SAAS SAAS010137.

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS010137 Lipid synthesis
Cellular component	Cytoplasm SAAS SAAS010137
Domain	Repeat SAAS SAAS010137
Molecular function	Acyltransferase SAAS SAAS010137 EMBL CAL66744.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0M299 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 8FE38E36A12C9A7C	FASTA	261	28,664
	10 20 30 40 50 60 MNQPLAYVHP GAKIAKNVVI EPFATIHNNV VIGEGTWIGS NVSIMEGARI GKNCSIFPGA 70 80 90 100 110 120 VISAVPQDKK FNDEDTLTVI GDNTTIRECV TINRGTTDRM KTVIGNNCWI MAYCHIAHDC 130 140 150 160 170 180 IVGDNCIFSN NSTLAGHINV GEHVILAGMA AIQQFCSIGK HAFVTGGSLV RKDVPPFVKA 190 200 210 220 230 240 GREPLSYVGI NSIGLRRRGF STEKIREIQD IYRILYQKNY NNSQAVAIIE AEMQATAERD 250 260 EILEFIKNSQ RGIMKGYFSS N

References

[1]

"Whole genome analysis of the marine Bacteroidetes'Gramella forsetii' reveals adaptations to degradation of polymeric organic matter." Bauer M., Kube M., Teeling H., Richter M., Lombardot T., Allers E., Wuerdemann C.A., Quast C., Kuhl H., Knaust F., Woebken D., Bischof K., Mussmann M., Choudhuri J.V., Meyer F., Reinhardt R., Amann R.I., Gloeckner F.O. Environ. Microbiol. 8:2201-2213(2006) [PubMed: 17107561] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU207366 Genomic DNA. Translation: CAL66744.1.
RefSeq	YP_861811.1. NC_008571.1.
3D structure databases
ProteinModelPortal	A0M299.
ModBase	Search...
Protein-protein interaction databases
STRING	A0M299.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4652411.
GenomeReviews	Gene locus GFO_1774 in contig CU207366_GR.
KEGG	gfo:GFO_1774.
NMPDR	fig|411154.5.peg.1677.
PATRIC	22072327. VBIGraFor5527_1706.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1043.
HOGENOM	HBG659295.
OMA	REFCTFN.
PhylomeDB	A0M299.
ProtClustDB	PRK05289.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR010137. Lipid_A_lpxA. IPR011004. Trimer_LpxA-like. [Graphical view]
KO	K00677.
Pfam	PF00132. Hexapep. 3 hits. [Graphical view]
PIRSF	PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01852. Lipid_A_lpxA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0M299_GRAFK

Accession

Primary (citable) accession number: A0M299

Entry history

Integrated into UniProtKB/TrEMBL:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)