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Protein

Catalase-peroxidase

Gene

katG

Organism
Gramella forsetii (strain KT0803)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei109 – 1091Transition state stabilizerUniRule annotation
Active sitei113 – 1131Proton acceptorUniRule annotation
Metal bindingi276 – 2761Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciGFOR411154:GI79-850-MONOMER.

Protein family/group databases

PeroxiBasei6253. GfoCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:GFO_0850
OrganismiGramella forsetii (strain KT0803)
Taxonomic identifieri411154 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeGramella
Proteomesi
  • UP000000755 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 750750Catalase-peroxidasePRO_0000354804Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki112 ↔ 235Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-261)UniRule annotation
Cross-linki235 ↔ 261Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-112)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi411154.GFO_0850.

Structurei

3D structure databases

ProteinModelPortaliA0LZM9.
SMRiA0LZM9. Positions 37-749.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0LZM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNNKSGSED NHKVWEVNES SKCPFMGGAL NKTAGKGTSN RDWWPNQLNL
60 70 80 90 100
NILRQNSSLI NPMDDGFNYA EAFKSLDLNA VKQDIYDLMT NSQDWWPADY
110 120 130 140 150
GHYGPFFIRM AWHSAGTYRI GDGRGGAGSG QQRFAPLNSW PDNANLDKAR
160 170 180 190 200
LLLWPVKKKY GKNLSWADLL VLAGNCAHES MGLKMFGFAG GREDVWEPAQ
210 220 230 240 250
DVYWGAETEW LNNDERYAGE ELENPLGAAH MGLIYVNPEG HNGNPDPVEA
260 270 280 290 300
ASYIRETFGR MAMNDYETVA LIAGGHTFGK THGAADAEEY VEAEPAAAGI
310 320 330 340 350
ESQGLGWKNT FGTGNGADTI TSGIEGAWTD TPTKWSNKYF DNLFKYDWEC
360 370 380 390 400
IKGPGGAYQW QPKDNAGAGT VPDAHDPDKK HAPFMLTTDL SLKMDPEYEK
410 420 430 440 450
ISRHFYENPD EFADAYSRAW FKLTHRDMGP IERYLGPEVP KEELLWQDPI
460 470 480 490 500
PKVDHEIIND SDIASLKNKI LNTGLSVQEL VTTAWGSAST FRGSDKRGGA
510 520 530 540 550
NGGRIRLAPQ NGWEVNNPKQ LGKVIDTLEK IQQDFNESQS GSKKVSIADL
560 570 580 590 600
IVLAGCVGVE KAAKTAGHEL KVPFSPGRAD ASQEQTDVEA FEPLEPNADG
610 620 630 640 650
FRNYFRNRDH VSASAEELLV DRAQLLTLTV PQMTVLLGGM RAMGANYDGS
660 670 680 690 700
KKGVFTDRPG QLTNDFFKNI LEMGLTWKSS SDSETEFDGS DRKTGDVKWT
710 720 730 740 750
GSRADLIFGS NSELRAIAEV YGTDDVEAKF VKDFVKAWDK VMNLDRYDLK
Length:750
Mass (Da):83,111
Last modified:December 12, 2006 - v1
Checksum:i5D1FB60D78C142B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207366 Genomic DNA. Translation: CAL65824.1.
RefSeqiWP_011708761.1. NC_008571.1.

Genome annotation databases

EnsemblBacteriaiCAL65824; CAL65824; GFO_0850.
KEGGigfo:GFO_0850.
PATRICi22070551. VBIGraFor5527_0822.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207366 Genomic DNA. Translation: CAL65824.1.
RefSeqiWP_011708761.1. NC_008571.1.

3D structure databases

ProteinModelPortaliA0LZM9.
SMRiA0LZM9. Positions 37-749.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi411154.GFO_0850.

Protein family/group databases

PeroxiBasei6253. GfoCP01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL65824; CAL65824; GFO_0850.
KEGGigfo:GFO_0850.
PATRICi22070551. VBIGraFor5527_0822.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciGFOR411154:GI79-850-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_GRAFK
AccessioniPrimary (citable) accession number: A0LZM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: December 12, 2006
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.