A0LZ81 (ARAA_GRAFK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase
EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	GFO_0699

Organism

Gramella forsetii (strain KT0803) [Complete proteome] [HAMAP]

Taxonomic identifier

411154 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Gramella

Protein attributes

Sequence length	502 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW fucose metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC L-fucose isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 502	502	L-arabinose isomerase HAMAP MF_00519		PRO_0000312608
Sites
	Metal binding	306	1	Manganese By similarity
	Metal binding	333	1	Manganese By similarity
	Metal binding	350	1	Manganese By similarity
	Metal binding	449	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0LZ81 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 9FEAD81837E336DE	FASTA	502	56,049
	10 20 30 40 50 60 MTNFENKEVW FITGSQHLYG EETLRQVANN SKEIVEGLNG SDNVPVKLIH QDTVKSSDEI 70 80 90 100 110 120 TKVMLDANNS SSCIGVILWM HTFSPAKMWI KGLSIIKKPI CHFHTQFNAE IPWSKIDMDF 130 140 150 160 170 180 MNLNQSAHGD REFGFIMSRM RKKRKVIVGH WKTEVTQKKV GNWQRVALGW DELQHIKVAR 190 200 210 220 230 240 IGDNMRQVAV TEGDKVAAQI KFGVEVNAYD SSDVTQHIDK VSDDEVNSLL KKYEKDYDLT 250 260 270 280 290 300 DALKDGGDQR QSLVDAAKIE LGLRAFLEEG GFMAFTDTFE NLGALKQLPG LAVQRLMADG 310 320 330 340 350 360 YGFGAEGDWK TAALLRAMKV MAQGMEGGTS FMEDYTNHFT EGKDYVLGSH MLEICPSIAD 370 380 390 400 410 420 SKPTCEVHPL GIGGKEDPVR LVFNSPKGKA LNASLVDMGT RFRLIVNEVE AVEPEADLPN 430 440 450 460 470 480 LPVARVLWDP KPDMDTAVTA WILAGGAHHT VYTQALSTEF LEDFADIAGI ELLVIDDNTS 490 500 VRQFKDTLNA NEAYYHLFQH GM

References

[1]

"Whole genome analysis of the marine Bacteroidetes'Gramella forsetii' reveals adaptations to degradation of polymeric organic matter." Bauer M., Kube M., Teeling H., Richter M., Lombardot T., Allers E., Wuerdemann C.A., Quast C., Kuhl H., Knaust F., Woebken D., Bischof K., Mussmann M., Choudhuri J.V., Meyer F., Reinhardt R., Amann R.I., Gloeckner F.O. Environ. Microbiol. 8:2201-2213(2006) [PubMed: 17107561] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KT0803.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU207366 Genomic DNA. Translation: CAL65676.1.
RefSeq	YP_860743.1. NC_008571.1.
3D structure databases
ProteinModelPortal	A0LZ81.
SMR	A0LZ81. Positions 1-497.
ModBase	Search...
Protein-protein interaction databases
STRING	A0LZ81.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4652269.
GenomeReviews	Gene locus GFO_0699 in contig CU207366_GR.
KEGG	gfo:GFO_0699.
NMPDR	fig|411154.5.peg.663.
PATRIC	22070245. VBIGraFor5527_0672.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2160.
HOGENOM	HBG297198.
OMA	EVCPTIA.
PhylomeDB	A0LZ81.
ProtClustDB	PRK02929.
Enzyme and pathway databases
BioCyc	GFOR411154:GFO_0699-MONOMER.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR024664. Ara_Isoase_C. IPR004216. Fuc/Ara_isomerase_C. IPR009015. Fucose_isomerase_N/cen. IPR003762. Lara_isomerase. [Graphical view]
KO	K01804.
Pfam	PF11762. Arabinose_Iso_C. 1 hit. PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAA_GRAFK

Accession

Primary (citable) accession number: A0LZ81

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program