A0LXV8 (PPNK_GRAFK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	GFO_0215

Organism

Gramella forsetii (strain KT0803) [Complete proteome] [HAMAP]

Taxonomic identifier

411154 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Gramella

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_1000059868

Sequences

	Sequence		Length	Mass (Da)
	A0LXV8 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 2F564AF62A04D97A	FASTA	294	33,126
	10 20 30 40 50 60 MKIGIYGQFY HANAAQYIGQ LLELLDQRNI EVLIEEDFLK LIHSNNKIEK DYKHFSAFEE 70 80 90 100 110 120 LDNSFDLFFC IGGDGTILKS INYIRNLDIP IVGINTGRLG FLATIQKEQI ESTLEELLEK 130 140 150 160 170 180 KFSLSPRSVL TMQTNPRSYD PVFSHIALNE IAVSRKNTTS MITVDTWLDD QYLTSYWADG 190 200 210 220 230 240 LIISTPTGST GYSLSCGGPV ITPDADSLVI TPIAPHNLNA RPLVIKDHTT IKLKVSGRGK 250 260 270 280 290 EHLVSMDSRI ATLQNDTEII IKKAPYTINF VELQGDSFLN TLRKKLLWGE DKRN

References

[1]

"Whole genome analysis of the marine Bacteroidetes'Gramella forsetii' reveals adaptations to degradation of polymeric organic matter." Bauer M., Kube M., Teeling H., Richter M., Lombardot T., Allers E., Wuerdemann C.A., Quast C., Kuhl H., Knaust F., Woebken D., Bischof K., Mussmann M., Choudhuri J.V., Meyer F., Reinhardt R., Amann R.I., Gloeckner F.O. Environ. Microbiol. 8:2201-2213(2006) [PubMed: 17107561] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KT0803.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU207366 Genomic DNA. Translation: CAL65203.1.
RefSeq	YP_860276.1. NC_008571.1.
3D structure databases
ProteinModelPortal	A0LXV8.
ModBase	Search...
Protein-protein interaction databases
STRING	A0LXV8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4650428.
GenomeReviews	Gene locus GFO_0215 in contig CU207366_GR.
KEGG	gfo:GFO_0215.
NMPDR	fig|411154.5.peg.203.
PATRIC	22069299. VBIGraFor5527_0210.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0061.
HOGENOM	HBG713904.
OMA	KLGWGLP.
PhylomeDB	A0LXV8.
ProtClustDB	PRK01911.
Enzyme and pathway databases
BioCyc	GFOR411154:GFO_0215-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_GRAFK

Accession

Primary (citable) accession number: A0LXV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program