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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Gramella forsetii (strain KT0803)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52S-adenosyl-L-methionineUniRule annotation1
Binding sitei77S-adenosyl-L-methionineUniRule annotation1
Active sitei126By similarity1
Binding sitei126S-adenosyl-L-methionineUniRule annotation1
Binding sitei130SubstrateUniRule annotation1
Binding sitei162SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciGFOR411154:G1GJG-119-MONOMER
UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:GFO_0120
OrganismiGramella forsetii (strain KT0803)
Taxonomic identifieri411154 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeGramella
Proteomesi
  • UP000000755 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002881521 – 224tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST224

Proteomic databases

PRIDEiA0LXL4

Interactioni

Protein-protein interaction databases

STRINGi411154.GFO_0120

Structurei

3D structure databases

ProteinModelPortaliA0LXL4
SMRiA0LXL4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107UGT Bacteria
COG0220 LUCA
HOGENOMiHOG000251689
KOiK03439
OMAiWITFPDP
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

A0LXL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKNKLRRF KENEKFENVI QPSREELTDN VFELKGKWSE NFFKNDHPIV
60 70 80 90 100
LELGCGKGEY TVELARKNPD KNFIGIDIKG ARFWRGAKTA LEEGLDNVAF
110 120 130 140 150
IRTQIELIEY VFATNEVSEI WITFPDPQIK YKRTKHRLTN TDFLQRYKNV
160 170 180 190 200
LKQDGIMHLK TDSEFMHGYT LGLLHGEGHE ILYAHHDIYK NEYSPKEVTG
210 220
IQTFYENQYL ENGKPITYIR FKIK
Length:224
Mass (Da):26,415
Last modified:December 12, 2006 - v1
Checksum:iCBBAF564FB4793A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207366 Genomic DNA Translation: CAL65109.1
RefSeqiWP_011708047.1, NC_008571.1

Genome annotation databases

EnsemblBacteriaiCAL65109; CAL65109; GFO_0120
KEGGigfo:GFO_0120

Similar proteinsi

Entry informationi

Entry nameiTRMB_GRAFK
AccessioniPrimary (citable) accession number: A0LXL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 12, 2006
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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