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Protein

dCTP deaminase

Gene

dcd

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:Acel_2112
OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
Taxonomic identifieri351607 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaAcidothermalesAcidothermaceaeAcidothermus
Proteomesi
  • UP000008221 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000096691 – 191dCTP deaminaseAdd BLAST191

Proteomic databases

PRIDEiA0LWS4.

Interactioni

Protein-protein interaction databases

STRINGi351607.Acel_2112.

Structurei

3D structure databases

ProteinModelPortaliA0LWS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP. Bacteria.
COG0717. LUCA.
HOGENOMiHOG000228601.
KOiK01494.
OMAiCISYGLS.
OrthoDBiPOG091H021I.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase. 1 hit.
InterProiIPR011962. dCTP_deam.
IPR010550. dCTP_deam_bac.
IPR029054. dUTPase-like.
IPR033704. dUTPase_trimeric.
[Graphical view]
PfamiPF06559. DCD. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

A0LWS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSDRDIRA ELASGRVTID PFDPAMIQPS SIDVRLDKYF RVFENHRYPH
60 70 80 90 100
IDPAVEQPDL TRLVETEGDE PFILHPGEFV LASTYEVIAL PDDLAGRLEG
110 120 130 140 150
KSSLGRLGLL THSTAGWIDP GFTGHVTLEL SNVATLPIKL WPGMKIGQLC
160 170 180 190
LFRTSSPAEH PYGSPVYGSR YQGQRGPTPS RSWQNFHRTK I
Length:191
Mass (Da):21,336
Last modified:December 12, 2006 - v1
Checksum:i51AEC2DEFE4B79B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA. Translation: ABK53884.1.
RefSeqiWP_011720947.1. NC_008578.1.

Genome annotation databases

EnsemblBacteriaiABK53884; ABK53884; Acel_2112.
KEGGiace:Acel_2112.
PATRICi20674882. VBIAciCel132453_2251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA. Translation: ABK53884.1.
RefSeqiWP_011720947.1. NC_008578.1.

3D structure databases

ProteinModelPortaliA0LWS4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi351607.Acel_2112.

Proteomic databases

PRIDEiA0LWS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK53884; ABK53884; Acel_2112.
KEGGiace:Acel_2112.
PATRICi20674882. VBIAciCel132453_2251.

Phylogenomic databases

eggNOGiENOG4105DHP. Bacteria.
COG0717. LUCA.
HOGENOMiHOG000228601.
KOiK01494.
OMAiCISYGLS.
OrthoDBiPOG091H021I.

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase. 1 hit.
InterProiIPR011962. dCTP_deam.
IPR010550. dCTP_deam_bac.
IPR029054. dUTPase-like.
IPR033704. dUTPase_trimeric.
[Graphical view]
PfamiPF06559. DCD. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDCD_ACIC1
AccessioniPrimary (citable) accession number: A0LWS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: November 30, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.