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A0LWE6 (A0LWE6_ACIC1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123
Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123
Gene names
Name:acsA HAMAP MF_01123
Ordered Locus Names:Acel_1984
OrganismAcidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]
Taxonomic identifier351607 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length657 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site5201 By similarity HAMAP MF_01123

Amino acid modifications

Modified residue6161N6-acetyllysine By similarity HAMAP MF_01123

Sequences

Sequence LengthMass (Da)Tools
A0LWE6 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 57974447D955DDCD

FASTA65771,879
        10         20         30         40         50         60 
MSATSPTLAN LLHEQRRFDP PPELAANAIA TASIYEEAAR DRLAFWAAQA ERLTWATPWE 

        70         80         90        100        110        120 
QVLDWSDAPF ARWFVGGRLN AAVNCLDRHV AAGYGGKVAF YWEGEPGDTR VITYAELTAM 

       130        140        150        160        170        180 
VCQAANALTE LGVTAGDRVM IYMPMIPETV VAMLACARIG AVHSVVFGGF SAEALAGRTN 

       190        200        210        220        230        240 
DAQARLIITA DGGFRRGAAH ALKPAVDDAC AQCPQVDKVL VVRRTGQDIP WNDGRDIWWH 

       250        260        270        280        290        300 
DIVDRQPSTH EAQAFDAEHP LYIMYTSGTT AKPKGILHTT GGYLTGVTAT HRMVFDLHED 

       310        320        330        340        350        360 
TDLYWCGADI GWVTGHSYIV YGPLANRATS FMYEGTPDTP AKDRWWQMIE KYRVSILYTA 

       370        380        390        400        410        420 
PTTIRTFMKW GEEWPAKHDL SSLRVLGSVG EPINPEAWIW YRTHIGGNRC PIVDTWWQTE 

       430        440        450        460        470        480 
TGSIMITPLP GVTSTKPGAA MRAFPGITVD VVDNDGNPVP NGSGGYLVIT EPWPSMLRGI 

       490        500        510        520        530        540 
WGDPQRYIDT YWSRFPGKYF AGDGAKRDED GDIWLLGRVD DVMNVSGHRI STTEVEHALV 

       550        560        570        580        590        600 
SHPKVAEAAV VGTHDPVTGQ AIVAFVTVKG SVPADEAQGA AFAAELRAHV AKEIGPIAKP 

       610        620        630        640        650 
RDILITADLP KTRSGKIMRR LLRDIADHRE LGDTTTLLDP GVVQQIAAQL AGSGNEE

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References

[1]"Complete sequence of Acidothermus cellulolyticus 11B."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000481 Genomic DNA. Translation: ABK53756.1.
RefSeqYP_873742.1. NC_008578.1.

3D structure databases

ProteinModelPortalA0LWE6.
SMRA0LWE6. Positions 20-650.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0LWE6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4486563.
GenomeReviewsGene locus Acel_1984 in contig CP000481_GR.
KEGGace:Acel_1984.
PATRIC20674584. VBIAciCel132453_2111.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0365.
HOGENOMHBG547964.
OMAHEERIHA.
PhylomeDBA0LWE6.

Family and domain databases

HAMAPMF_01123. Ac_CoA_synth.
[Tree]
InterProIPR011904. Ac_CoA_lig.
IPR024597. Acyl-CoA_synth_DUF3448.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01895.
PANTHERPTHR24095:SF42. PTHR24095:SF42. 1 hit.
PfamPF00501. AMP-binding. 1 hit.
PF11930. DUF3448. 1 hit.
[Graphical view]
TIGRFAMsTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA0LWE6_ACIC1
AccessionPrimary (citable) accession number: A0LWE6
Entry history
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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