Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Inositol 2-dehydrogenase

Gene

iolG

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).UniRule annotation

Catalytic activityi

Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH.UniRule annotation

GO - Molecular functioni

  1. inositol 2-dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. inositol catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciACEL351607:GIXW-1850-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 2-dehydrogenaseUniRule annotation (EC:1.1.1.18UniRule annotation)
Alternative name(s):
Myo-inositol 2-dehydrogenaseUniRule annotation
Short name:
MI 2-dehydrogenaseUniRule annotation
Gene namesi
Name:iolGUniRule annotation
Ordered Locus Names:Acel_1809
OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
Taxonomic identifieri351607 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeAcidothermaceaeAcidothermus
ProteomesiUP000008221 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Inositol 2-dehydrogenasePRO_0000352549Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi351607.Acel_1809.

Structurei

3D structure databases

ProteinModelPortaliA0LVX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gfo/Idh/MocA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0673.
HOGENOMiHOG000227439.
KOiK00010.
OMAiDIQCEIV.
OrthoDBiEOG6GFGMS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01671. IolG.
InterProiIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0LVX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDRSVRIG LIGAGAIGED HARRLSTVIR GADVVAVHDV DPSRAKTVAT
60 70 80 90 100
RFRDARVIPD GNSLIGDPDV DAVVVASAAP THEAYVLAAI AARKPVFCEK
110 120 130 140 150
PLATTAAGCL RIVEAEKAHG RRFVRVGFMR RFDPAYLGLK AELRSGAIGH
160 170 180 190 200
PLLAHLAHRN PAVPSTLRTT DAIADSLVHE MDLVRWLFDT EIREVRAVAG
210 220 230 240 250
RRNAKAGPDL HDPLLVLVRM ATDVVVDVEL SLNIGYGYHI RAEIVGENGT
260 270 280 290 300
VALASEQPIV RRISGEERRP VAQHWKTRFA AAYDAELSEW VRDVSQGRVS
310 320 330 340
GPSAWDGYAA TLATDAAAES LRSDTAVAAF PGDVPTLYRE P
Length:341
Mass (Da):36,761
Last modified:December 12, 2006 - v1
Checksum:i9B5142D9C73CA3E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA. Translation: ABK53581.1.
RefSeqiWP_011720644.1. NC_008578.1.
YP_873567.1. NC_008578.1.

Genome annotation databases

EnsemblBacteriaiABK53581; ABK53581; Acel_1809.
KEGGiace:Acel_1809.
PATRICi20674210. VBIAciCel132453_1927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA. Translation: ABK53581.1.
RefSeqiWP_011720644.1. NC_008578.1.
YP_873567.1. NC_008578.1.

3D structure databases

ProteinModelPortaliA0LVX1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi351607.Acel_1809.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK53581; ABK53581; Acel_1809.
KEGGiace:Acel_1809.
PATRICi20674210. VBIAciCel132453_1927.

Phylogenomic databases

eggNOGiCOG0673.
HOGENOMiHOG000227439.
KOiK00010.
OMAiDIQCEIV.
OrthoDBiEOG6GFGMS.

Enzyme and pathway databases

BioCyciACEL351607:GIXW-1850-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01671. IolG.
InterProiIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43068 / 11B.

Entry informationi

Entry nameiIOLG_ACIC1
AccessioniPrimary (citable) accession number: A0LVX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: December 12, 2006
Last modified: April 29, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.