A0LVX1 (IOLG_ACIC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Acel_1809

Organism

Acidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]

Taxonomic identifier

351607 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus › Acidothermus cellulolyticus

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP-Rule MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP-Rule MF_01671
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the Gfo/Idh/MocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 341	341	Inositol 2-dehydrogenase HAMAP-Rule MF_01671		PRO_0000352549

Sequences

	Sequence		Length	Mass (Da)
	A0LVX1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 9B5142D9C73CA3E1	FASTA	341	36,761
	10 20 30 40 50 60 MATDRSVRIG LIGAGAIGED HARRLSTVIR GADVVAVHDV DPSRAKTVAT RFRDARVIPD 70 80 90 100 110 120 GNSLIGDPDV DAVVVASAAP THEAYVLAAI AARKPVFCEK PLATTAAGCL RIVEAEKAHG 130 140 150 160 170 180 RRFVRVGFMR RFDPAYLGLK AELRSGAIGH PLLAHLAHRN PAVPSTLRTT DAIADSLVHE 190 200 210 220 230 240 MDLVRWLFDT EIREVRAVAG RRNAKAGPDL HDPLLVLVRM ATDVVVDVEL SLNIGYGYHI 250 260 270 280 290 300 RAEIVGENGT VALASEQPIV RRISGEERRP VAQHWKTRFA AAYDAELSEW VRDVSQGRVS 310 320 330 340 GPSAWDGYAA TLATDAAAES LRSDTAVAAF PGDVPTLYRE P

References

[1]

"Complete sequence of Acidothermus cellulolyticus 11B." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000481 Genomic DNA. Translation: ABK53581.1.
RefSeq	YP_873567.1. NC_008578.1.
3D structure databases
ProteinModelPortal	A0LVX1.
ModBase	Search...
Protein-protein interaction databases
STRING	351607.Acel_1809.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABK53581; ABK53581; Acel_1809.
GeneID	4485708.
KEGG	ace:Acel_1809.
PATRIC	20674210. VBIAciCel132453_1927.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HOG000227439.
KO	K00010.
OMA	YDVELQD.
Enzyme and pathway databases
BioCyc	ACEL351607:GIXW-1850-MONOMER.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_01671. IolG.
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_ACIC1

Accession

Primary (citable) accession number: A0LVX1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	December 12, 2006
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program