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Protein

Inositol 2-dehydrogenase

Gene

iolG

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).UniRule annotation

Catalytic activityi

Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciACEL351607:G1G7K-1855-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 2-dehydrogenaseUniRule annotation (EC:1.1.1.18UniRule annotation)
Alternative name(s):
Myo-inositol 2-dehydrogenaseUniRule annotation
Short name:
MI 2-dehydrogenaseUniRule annotation
Gene namesi
Name:iolGUniRule annotation
Ordered Locus Names:Acel_1809
OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
Taxonomic identifieri351607 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaAcidothermalesAcidothermaceaeAcidothermus
Proteomesi
  • UP000008221 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003525491 – 341Inositol 2-dehydrogenaseAdd BLAST341

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi351607.Acel_1809

Structurei

3D structure databases

ProteinModelPortaliA0LVX1
SMRiA0LVX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gfo/Idh/MocA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DRI Bacteria
COG0673 LUCA
HOGENOMiHOG000227439
KOiK00010
OMAiHCRHRNP
OrthoDBiPOG091H0FNG

Family and domain databases

HAMAPiMF_01671 IolG, 1 hit
InterProiView protein in InterPro
IPR023794 MI/DCI_dehydrogenase
IPR036291 NAD(P)-bd_dom_sf
IPR000683 Oxidoreductase_N
IPR004104 OxRdtase_C
PfamiView protein in Pfam
PF01408 GFO_IDH_MocA, 1 hit
PF02894 GFO_IDH_MocA_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

A0LVX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDRSVRIG LIGAGAIGED HARRLSTVIR GADVVAVHDV DPSRAKTVAT
60 70 80 90 100
RFRDARVIPD GNSLIGDPDV DAVVVASAAP THEAYVLAAI AARKPVFCEK
110 120 130 140 150
PLATTAAGCL RIVEAEKAHG RRFVRVGFMR RFDPAYLGLK AELRSGAIGH
160 170 180 190 200
PLLAHLAHRN PAVPSTLRTT DAIADSLVHE MDLVRWLFDT EIREVRAVAG
210 220 230 240 250
RRNAKAGPDL HDPLLVLVRM ATDVVVDVEL SLNIGYGYHI RAEIVGENGT
260 270 280 290 300
VALASEQPIV RRISGEERRP VAQHWKTRFA AAYDAELSEW VRDVSQGRVS
310 320 330 340
GPSAWDGYAA TLATDAAAES LRSDTAVAAF PGDVPTLYRE P
Length:341
Mass (Da):36,761
Last modified:December 12, 2006 - v1
Checksum:i9B5142D9C73CA3E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA Translation: ABK53581.1
RefSeqiWP_011720644.1, NC_008578.1

Genome annotation databases

EnsemblBacteriaiABK53581; ABK53581; Acel_1809
KEGGiace:Acel_1809

Entry informationi

Entry nameiIOLG_ACIC1
AccessioniPrimary (citable) accession number: A0LVX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: December 12, 2006
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health