A0LVN5 (A0LVN5_ACIC1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
EC=2.1.1.14 HAMAP MF_00172

Alternative name(s):
Cobalamin-independent methionine synthase HAMAP MF_00172
Methionine synthase, vitamin-B12 independent isozyme HAMAP MF_00172

Gene names

Name:	metE HAMAP MF_00172
Ordered Locus Names:	Acel_1723

Organism

Acidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]

Taxonomic identifier

351607 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length	784 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172 SAAS SAAS013215
Catalytic activity	5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172 SAAS SAAS013215
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172 SAAS SAAS013215
Sequence similarities	Belongs to the vitamin-B12 independent methionine synthase family. HAMAP MF_00172

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Methionine biosynthesis HAMAP MF_00172 SAAS SAAS013215
Domain	Repeat HAMAP MF_00172
Ligand	Metal-binding HAMAP MF_00172 SAAS SAAS013215 Zinc HAMAP MF_00172 SAAS SAAS013215
Molecular function	Methyltransferase HAMAP MF_00172 SAAS SAAS013215 EMBL ABK53495.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	668	1	Zinc By similarity HAMAP MF_00172
	Metal binding	670	1	Zinc By similarity HAMAP MF_00172
	Metal binding	753	1	Zinc By similarity HAMAP MF_00172

Sequences

	Sequence		Length	Mass (Da)
	A0LVN5 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 2A24024335B6C911	FASTA	784	86,095
	10 20 30 40 50 60 MTTTRSSSNR PQGPRSRSTV YGYPRQGPGR QLKKLTEAYW AGRLDADAFL AQTRELRRAR 70 80 90 100 110 120 WIELRDAGID EIPSNDFSYY DHVLDTAVML GALPRRHAPA LADAGQSPAA RLDRYFALAR 130 140 150 160 170 180 GNDDAAPLEM TKWFTTNYHY LVPELRPDME FRLDPTKPLS EFREARELGL TTRPVILGPV 190 200 210 220 230 240 SFLLLSKREP GVPGDFQPLS LLGKIICPYL ELIRRLFDAG AEWVQFDEPC LVADQPAQVL 250 260 270 280 290 300 DAVATAYATL CAEEFRPRLL VATYFDRLGD ALPVLADSPV DGIAMDITGP ARANIDDLAA 310 320 330 340 350 360 IGGIPTKRLV AGVVDGRNVW RTDLAAALST LGTLLGLAGQ VDVSASCSLL HVPLSIEFER 370 380 390 400 410 420 QLDPQIAGWL AFARQKLEEI VILTRGLNDG WEAVAGDLQV SAARRATRLA SPIVQVDAVR 430 440 450 460 470 480 RRAAEAAGLP RTRRSPYAER RIVQRRQLGL PALPTTTIGS FPQTPALRAA RAKLRAGELD 490 500 510 520 530 540 AAGYEALIEA EIAAVIAEQE AAGLDVLVHG EPERNDMVQY FAEQLDGFLT TAEGWVQSYG 550 560 570 580 590 600 TRYVRPPIVV GDVARRGPMT VRWATYAAGR TQKPVKGMLT GPVTMLAWSF VRDDLPRAEV 610 620 630 640 650 660 ARQVALALRD EVLDLEAAGL RVIQIDEPAL RESLPLRNAD RAEYLSWAVD AFRLVTSGVR 670 680 690 700 710 720 DETQIHTHMC YAEFGDILQA LIDMDADVIS LEAARSDMAI VTDLARAGYP NDIGPGVWDV 730 740 750 760 770 780 HSPRIPTVQE IVDRIHLALK ECPADRLWIN PDCGLKTRGY AEVRPALANM VAAARAVRAE LGLV

References

[1]

"Complete sequence of Acidothermus cellulolyticus 11B." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000481 Genomic DNA. Translation: ABK53495.1.
RefSeq	YP_873481.1. NC_008578.1.
3D structure databases
ProteinModelPortal	A0LVN5.
ModBase	Search...
Protein-protein interaction databases
STRING	A0LVN5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4484878.
GenomeReviews	Gene locus Acel_1723 in contig CP000481_GR.
KEGG	ace:Acel_1723.
PATRIC	20674024. VBIAciCel132453_1834.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0620.
HOGENOM	HBG287495.
OMA	RNIWRAN.
PhylomeDB	A0LVN5.
ProtClustDB	PRK05222.
Family and domain databases
HAMAP	MF_00172. Meth_synth. [Tree]
InterPro	IPR013215. Cbl-indep_Met_Synth_N. IPR006276. Cobalamin-indep_Met_synthase. IPR002629. Methionine_synth. [Graphical view]
KO	K00549.
Pfam	PF08267. Meth_synt_1. 1 hit. PF01717. Meth_synt_2. 1 hit. [Graphical view]
PIRSF	PIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMs	TIGR01371. Met_syn_B12ind. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0LVN5_ACIC1

Accession

Primary (citable) accession number: A0LVN5

Entry history

Integrated into UniProtKB/TrEMBL:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)