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A0LV98 (A0LV98_ACIC1) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Acel_1586 EMBL ABK53358.1
OrganismAcidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP] EMBL ABK53358.1
Taxonomic identifier351607 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeAcidothermaceaeAcidothermus

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain159 – 367209ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding191 – 24656ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3211Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3341Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3341Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3361Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
A0LV98 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: A6BBDDD92A92036A

FASTA37740,082
        10         20         30         40         50         60 
MTLDTPQAGA ASDRPRVAVV FGGRSTEHAI SCLTAGGVMT ALTAAGYDVC AIGITRDGRW 

        70         80         90        100        110        120 
VLPPADPAPL TAKDGRLPEV DASHPPVVVV PDPADPGLFV RDVSGRLRSL GRIDVAFPVL 

       130        140        150        160        170        180 
HGPFGEDGTI QGLFEMAGIP YVGSGVFASA AAMDKQFMKV LFVGAGLPDV PHVVVTPDEW 

       190        200        210        220        230        240 
RTDPAAVRES VASLGFPVFV KPARGGSSVA VTKVHKPADV DEAIERAREV DPKVLVERAI 

       250        260        270        280        290        300 
DGREIEVGVL DDVHGGAPKV SVPAEILVRG REFYDFEAKY LDQGTVITIP ASLPPAVLQT 

       310        320        330        340        350        360 
VNRYAVIAYR ALGCEGLARV DFFVTATGEV FVNELNTMPG FTPTSVFPRV WQATGLEYPA 

       370 
LVDYLVQLAL RRRPGLR 

« Hide

References

[1]"Complete sequence of Acidothermus cellulolyticus 11B."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000481 Genomic DNA. Translation: ABK53358.1.
RefSeqYP_873344.1. NC_008578.1.

3D structure databases

ProteinModelPortalA0LV98.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING351607.Acel_1586.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABK53358; ABK53358; Acel_1586.
GeneID4485486.
KEGGace:Acel_1586.
PATRIC20673724. VBIAciCel132453_1690.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAIECGVLG.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycACEL351607:GIXW-1620-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0LV98_ACIC1
AccessionPrimary (citable) accession number: A0LV98
Entry history
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)