Reviewed, UniProtKB/Swiss-Prot A0LV49 (GLYA_ACIC1)

Names and origin

Protein names

Recommended name:
    Serine hydroxymethyltransferase
      Short name=Serine methylase
      Short name=SHMT
    EC=2.1.2.1

Gene names

Name:	glyA
Ordered Locus Names:	Acel_1537

Organism

Acidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]

Taxonomic identifier

351607 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length	427 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Interconversion of serine and glycine By similarity.
Catalytic activity	5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051
Cofactor	Pyridoxal phosphate By similarity.
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the SHMT family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-serine metabolic process Inferred from electronic annotation. Source: InterPro glycine metabolic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glycine hydroxymethyltransferase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 427	427	Serine hydroxymethyltransferase HAMAP MF_00051		PRO_0000369897
Amino acid modifications
	Modified residue	233	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0LV49-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: FF17AF9A37905087	FASTA	427	45,986
	10 20 30 40 50 60 MNSSPDPLAA LTATDPTIAD LIRAEERRQS EKIRLIPSEN YVSKAVLEAT GTVLTNKYSE 70 80 90 100 110 120 GYPNRRYYEG QQFIDQIETI AIERAKQLFG VDHANVQPYS GSPANLAIYL ALLSPGDTVM 130 140 150 160 170 180 GMALPMGGHL THGWPVSATG IWFRSVQYGV RRDTGRIDFD EVREVARRER PKVIFAGGTA 190 200 210 220 230 240 IPRIIDFAAF AEIAREVNAV LVADIAHISG LVAGGVHPSP VGHADIISTT THKTLRGPRG 250 260 270 280 290 300 AMLMSTEQYA KALDKAVFPG LQGGPHNHTT AAIAVALLEA MQPEFRDYAR NIVANAAVLA 310 320 330 340 350 360 EELLARGFDL VSGGTDNHLI LVDLTSKGVA GKPVARALDR AGIELNYNTV PFDPRKPFDP 370 380 390 400 410 420 SGIRLGTPAV TSRGMGPAEM RQIAAWIDEV TTAVAKGDEE ALAAVEQRVA GEVRELTKNF PTPGLDR

References

[1]

"Complete sequence of Acidothermus cellulolyticus 11B." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000481 Genomic DNA. Translation: ABK53309.1.
RefSeq	YP_873295.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0LV49.
Genome annotation databases
GeneID	4485210.
GenomeReviews	Gene locus Acel_1537 in contig CP000481_GR.
KEGG	ace:Acel_1537.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	TMADVSH.
Family and domain databases
HAMAP	MF_00051. [Tree]
InterPro	IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR001085. Ser_HO-MeTrfase. IPR019798. Ser_HO-MeTrfase_PLP_BS. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11680. Gly_HO-Metrfase. 1 hit.
Pfam	PF00464. SHMT. 1 hit. [Graphical view]
PIRSF	PIRSF000412. SHMT. 1 hit.
PROSITE	PS00096. SHMT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLYA_ACIC1

Accession

Primary (citable) accession number: A0LV49

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	December 12, 2006
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)