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A0LV36 (A0LV36_ACIC1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
Short name=DXP reductoisomerase HAMAP MF_00183
EC=1.1.1.267 HAMAP MF_00183
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase HAMAP MF_00183
2-C-methyl-D-erythritol 4-phosphate synthase HAMAP MF_00183
Gene names
Name:dxr HAMAP MF_00183
Ordered Locus Names:Acel_1524
OrganismAcidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]
Taxonomic identifier351607 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00183 SAAS SAAS003821

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183 SAAS SAAS003821

Cofactor

Divalent cation By similarity. HAMAP MF_00183 SAAS SAAS003821

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183 SAAS SAAS003821

Sequence similarities

Belongs to the DXR family. HAMAP MF_00183

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding27 – 5630NADP By similarity HAMAP MF_00183

Sites

Metal binding1811Divalent metal cation By similarity HAMAP MF_00183
Metal binding1831Divalent metal cation By similarity HAMAP MF_00183
Metal binding2521Divalent metal cation By similarity HAMAP MF_00183
Binding site1581Substrate By similarity HAMAP MF_00183
Binding site1831Substrate By similarity HAMAP MF_00183
Binding site2071Substrate By similarity HAMAP MF_00183
Binding site2301Substrate By similarity HAMAP MF_00183
Binding site2521Substrate By similarity HAMAP MF_00183

Sequences

Sequence LengthMass (Da)Tools
A0LV36 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 7E5197347BD9F324

FASTA42143,748
        10         20         30         40         50         60 
MSSSPLAPQP SSPMRAGRLP VRPLVILGST GSIGTQALDV VRNHPDLFRV VGLAASGSRL 

        70         80         90        100        110        120 
DLLTRQAVEF GVEVIGVTGA TPAEVEHALA AAAAERGCAA PHPKIVSGPE AAAEVAAWPL 

       130        140        150        160        170        180 
PVAEPRDGVV LNGITGSIGL APTVAALRAG RTLALANKES LIAGGPLVKA IAEPGQIVPV 

       190        200        210        220        230        240 
DSEHSALAQC LRAGRADEVR RLILTASGGP FRGRRRADLV GVTAEQALAH PTWRMGPVIT 

       250        260        270        280        290        300 
INSATLVNKA LEVIEAHLLF DISLDAIDVV IHPQSVVHSM VEFIDGSTVA HCSPPNMRLP 

       310        320        330        340        350        360 
IALALAWPYR LPAVIPSCDW RQATAWTFEP VDGETFPAID IARQVGAAGG VAPAAFNAAN 

       370        380        390        400        410        420 
EEAVAAFLAG RLDFLGIMDV VAAVTEKFLA APPVPVRSVS DVLDAEREAR RLADELIGGC 


R

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References

[1]"Complete sequence of Acidothermus cellulolyticus 11B."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000481 Genomic DNA. Translation: ABK53296.1.
RefSeqYP_873282.1. NC_008578.1.

3D structure databases

ProteinModelPortalA0LV36.
SMRA0LV36. Positions 23-419.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0LV36.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4486127.
GenomeReviewsGene locus Acel_1524 in contig CP000481_GR.
KEGGace:Acel_1524.
PATRIC20673592. VBIAciCel132453_1624.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0743.
HOGENOMHBG430762.
OMAIHSMVEY.
ProtClustDBPRK05447.

Family and domain databases

HAMAPMF_00183. DXP_reductoisom.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00099.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA0LV36_ACIC1
AccessionPrimary (citable) accession number: A0LV36
Entry history
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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