Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A0LV20

- PNP_ACIC1

UniProt

A0LV20 - PNP_ACIC1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi514 – 5141MagnesiumUniRule annotation
Metal bindingi520 – 5201MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciACEL351607:GIXW-1542-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Acel_1508
OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
Taxonomic identifieri351607 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeAcidothermaceaeAcidothermus
ProteomesiUP000008221: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 782782Polyribonucleotide nucleotidyltransferasePRO_0000329479Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351607.Acel_1508.

Structurei

3D structure databases

ProteinModelPortaliA0LV20.
SMRiA0LV20. Positions 4-717.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini580 – 63960KHUniRule annotationAdd
BLAST
Domaini651 – 72373S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiTIAGKQD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0LV20 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADHDVHTAE AVIDNGSFGV RTVRFETGRL ARQAGGSAVA YLGDTMVLSA
60 70 80 90 100
TTASKEPREQ FDFFPLTVDV EERLYAAGRI PGSFFRREGR PSEEAILTCR
110 120 130 140 150
LIDRPLRPSF VKGLRNEVQV VVTVLAVDPE HLYDVVAINA ASMSTLLAGL
160 170 180 190 200
PFSGPIGGVR MAHIDGTWVA FPTYSELERA TFDMVVAGRV LPDGDVAIMM
210 220 230 240 250
VEAEATEETI PLIREGAPAP TEEVVAGGLE AAKPFIRTLC AAQSELAARA
260 270 280 290 300
AKPVTEFPLF RDYEDDVYDA VAATVRDDVA RALTIAGKQE REAALDEVAN
310 320 330 340 350
TALGRLGERF AGREKEILAA LRALTKKLVR ERIIREKVRI DGRGLTDIRP
360 370 380 390 400
LTAEVGIVPR VHGSALFERG ETQILGVTTL NMLRMEQQLD TVSPRTKKRY
410 420 430 440 450
MHHYNFPPYS TGEVGRVGSP KRREIGHGAL AERALIPVLP SREEFPYAIR
460 470 480 490 500
QVSEAIGSNG STSMGSVCAS TLSLLNAGVP LRAPVAGIAM GLISDTVDGE
510 520 530 540 550
THYVTLTDIL GAEDAYGDMD FKVAGTRDFV TALQLDTKLD GIPASVLAAA
560 570 580 590 600
LPQAREARLT ILDVMAKAIS EPAPMSPYAP RIITIKIPVD QIGAVIGPKG
610 620 630 640 650
KIINQIQDDT GAEITIEDDG TIYIGATEGT AAEAARAAIS AIANPQLPEV
660 670 680 690 700
GERYLGTVVK ATPFGVFVSL LPGKDGLLHI SELRKMAGGR RVENVEDVLK
710 720 730 740 750
VGDKIQVEIR DIDARGKLSL VPVDVPGAVL AEDAGAGESA ASGGAPRSAG
760 770 780
GPQPREHQGP GRPRGRGGDH GGEGRQRTRR RH
Length:782
Mass (Da):83,621
Last modified:December 12, 2006 - v1
Checksum:iBA7AD1196DED3CC2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000481 Genomic DNA. Translation: ABK53280.1.
RefSeqiYP_873266.1. NC_008578.1.

Genome annotation databases

EnsemblBacteriaiABK53280; ABK53280; Acel_1508.
GeneIDi4486272.
KEGGiace:Acel_1508.
PATRICi20673554. VBIAciCel132453_1605.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000481 Genomic DNA. Translation: ABK53280.1 .
RefSeqi YP_873266.1. NC_008578.1.

3D structure databases

ProteinModelPortali A0LV20.
SMRi A0LV20. Positions 4-717.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351607.Acel_1508.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK53280 ; ABK53280 ; Acel_1508 .
GeneIDi 4486272.
KEGGi ace:Acel_1508.
PATRICi 20673554. VBIAciCel132453_1605.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi TIAGKQD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci ACEL351607:GIXW-1542-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43068 / 11B.

Entry informationi

Entry nameiPNP_ACIC1
AccessioniPrimary (citable) accession number: A0LV20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3