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A0LV20

- PNP_ACIC1

UniProt

A0LV20 - PNP_ACIC1

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi514 – 5141MagnesiumUniRule annotation
    Metal bindingi520 – 5201MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciACEL351607:GIXW-1542-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:Acel_1508
    OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
    Taxonomic identifieri351607 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeAcidothermaceaeAcidothermus
    ProteomesiUP000008221: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 782782Polyribonucleotide nucleotidyltransferasePRO_0000329479Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi351607.Acel_1508.

    Structurei

    3D structure databases

    ProteinModelPortaliA0LV20.
    SMRiA0LV20. Positions 4-717.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini580 – 63960KHUniRule annotationAdd
    BLAST
    Domaini651 – 72373S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiTIAGKQD.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR014069. pppGpp_PNP.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    TIGR02696. pppGpp_PNP. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0LV20-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADHDVHTAE AVIDNGSFGV RTVRFETGRL ARQAGGSAVA YLGDTMVLSA    50
    TTASKEPREQ FDFFPLTVDV EERLYAAGRI PGSFFRREGR PSEEAILTCR 100
    LIDRPLRPSF VKGLRNEVQV VVTVLAVDPE HLYDVVAINA ASMSTLLAGL 150
    PFSGPIGGVR MAHIDGTWVA FPTYSELERA TFDMVVAGRV LPDGDVAIMM 200
    VEAEATEETI PLIREGAPAP TEEVVAGGLE AAKPFIRTLC AAQSELAARA 250
    AKPVTEFPLF RDYEDDVYDA VAATVRDDVA RALTIAGKQE REAALDEVAN 300
    TALGRLGERF AGREKEILAA LRALTKKLVR ERIIREKVRI DGRGLTDIRP 350
    LTAEVGIVPR VHGSALFERG ETQILGVTTL NMLRMEQQLD TVSPRTKKRY 400
    MHHYNFPPYS TGEVGRVGSP KRREIGHGAL AERALIPVLP SREEFPYAIR 450
    QVSEAIGSNG STSMGSVCAS TLSLLNAGVP LRAPVAGIAM GLISDTVDGE 500
    THYVTLTDIL GAEDAYGDMD FKVAGTRDFV TALQLDTKLD GIPASVLAAA 550
    LPQAREARLT ILDVMAKAIS EPAPMSPYAP RIITIKIPVD QIGAVIGPKG 600
    KIINQIQDDT GAEITIEDDG TIYIGATEGT AAEAARAAIS AIANPQLPEV 650
    GERYLGTVVK ATPFGVFVSL LPGKDGLLHI SELRKMAGGR RVENVEDVLK 700
    VGDKIQVEIR DIDARGKLSL VPVDVPGAVL AEDAGAGESA ASGGAPRSAG 750
    GPQPREHQGP GRPRGRGGDH GGEGRQRTRR RH 782
    Length:782
    Mass (Da):83,621
    Last modified:December 12, 2006 - v1
    Checksum:iBA7AD1196DED3CC2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000481 Genomic DNA. Translation: ABK53280.1.
    RefSeqiYP_873266.1. NC_008578.1.

    Genome annotation databases

    EnsemblBacteriaiABK53280; ABK53280; Acel_1508.
    GeneIDi4486272.
    KEGGiace:Acel_1508.
    PATRICi20673554. VBIAciCel132453_1605.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000481 Genomic DNA. Translation: ABK53280.1 .
    RefSeqi YP_873266.1. NC_008578.1.

    3D structure databases

    ProteinModelPortali A0LV20.
    SMRi A0LV20. Positions 4-717.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351607.Acel_1508.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK53280 ; ABK53280 ; Acel_1508 .
    GeneIDi 4486272.
    KEGGi ace:Acel_1508.
    PATRICi 20673554. VBIAciCel132453_1605.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi TIAGKQD.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci ACEL351607:GIXW-1542-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR014069. pppGpp_PNP.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    TIGR02696. pppGpp_PNP. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43068 / 11B.

    Entry informationi

    Entry nameiPNP_ACIC1
    AccessioniPrimary (citable) accession number: A0LV20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3