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A0LUZ5

- DAPF_ACIC1

UniProt

A0LUZ5 - DAPF_ACIC1

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Protein
Diaminopimelate epimerase
Gene
dapF, Acel_1483
Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141Substrate By similarity
Binding sitei47 – 471Substrate By similarity
Binding sitei97 – 971Substrate By similarity
Active sitei106 – 1061Proton donor/acceptor By similarity
Binding sitei178 – 1781Substrate By similarity
Sitei180 – 1801Important for catalytic activity By similarity
Binding sitei209 – 2091Substrate By similarity
Sitei227 – 2271Important for catalytic activity By similarity
Active sitei236 – 2361Proton donor/acceptor By similarity

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciACEL351607:GIXW-1517-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimerase (EC:5.1.1.7)
Short name:
DAP epimerase
Gene namesi
Name:dapF
Ordered Locus Names:Acel_1483
OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
Taxonomic identifieri351607 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeAcidothermaceaeAcidothermus
ProteomesiUP000008221: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Diaminopimelate epimeraseUniRule annotation
PRO_1000077688Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi106 ↔ 236UniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi351607.Acel_1483.

Structurei

3D structure databases

ProteinModelPortaliA0LUZ5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 1083Substrate binding By similarity
Regioni227 – 2282Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220467.
KOiK01778.
OMAiAIRHWAG.
OrthoDBiEOG6ND0M5.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0LUZ5-1 [UniParc]FASTAAdd to Basket

« Hide

MDDVPFLKGH ATRNDFVILP DHDDELELDA ALVRAICDRR RGLGADGILR    50
VVAVPADDAP VSSAGATADA AAGRPPQPSA GRPPQPAAAR WFMDYRNADG 100
SVAEICGNGI RLFARYLVDA GLEEAGRFLV GTRIGPVPVD VPPAGDVTAW 150
LPAPELRGGG RARFDGRMLE GVRVSVGNPH LVCVVDTLAD VDFTRAPVLD 200
SDEFPDGANV EVVEIERPGV LRMRVYERGV GETWSCGSGA CAVAAVAEGA 250
ERIPRPADGW WRIVVPGGEL RIRFDGDRVA LAGPAVVVAE GRLHLAALEK 300
SDG 303
Length:303
Mass (Da):32,002
Last modified:December 12, 2006 - v1
Checksum:i3DBBBFB454EFDFE0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000481 Genomic DNA. Translation: ABK53255.1.
RefSeqiWP_011720318.1. NC_008578.1.
YP_873241.1. NC_008578.1.

Genome annotation databases

EnsemblBacteriaiABK53255; ABK53255; Acel_1483.
GeneIDi4485400.
KEGGiace:Acel_1483.
PATRICi20673496. VBIAciCel132453_1576.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000481 Genomic DNA. Translation: ABK53255.1 .
RefSeqi WP_011720318.1. NC_008578.1.
YP_873241.1. NC_008578.1.

3D structure databases

ProteinModelPortali A0LUZ5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 351607.Acel_1483.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK53255 ; ABK53255 ; Acel_1483 .
GeneIDi 4485400.
KEGGi ace:Acel_1483.
PATRICi 20673496. VBIAciCel132453_1576.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220467.
KOi K01778.
OMAi AIRHWAG.
OrthoDBi EOG6ND0M5.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci ACEL351607:GIXW-1517-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43068 / 11B.

Entry informationi

Entry nameiDAPF_ACIC1
AccessioniPrimary (citable) accession number: A0LUZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 12, 2006
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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