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Protein

Holliday junction ATP-dependent DNA helicase RuvA

Gene

ruvA

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACEL351607:GIXW-1374-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvAUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:ruvAUniRule annotation
Ordered Locus Names:Acel_1344
OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
Taxonomic identifieri351607 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaAcidothermalesAcidothermaceaeAcidothermus
Proteomesi
  • UP000008221 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Holliday junction ATP-dependent DNA helicase RuvAPRO_1000002383Add
BLAST

Interactioni

Subunit structurei

Forms a complex with RuvB.UniRule annotation

Protein-protein interaction databases

STRINGi351607.Acel_1344.

Structurei

3D structure databases

ProteinModelPortaliA0LUK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KA4. Bacteria.
COG0632. LUCA.
HOGENOMiHOG000057115.
KOiK03550.
OMAiGDDKAFT.
OrthoDBiEOG679THG.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00031. DNA_helic_RuvA.
InterProiIPR011114. DNA_helicas_Holl-junc_RuvA_C.
IPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
[Graphical view]
PfamiPF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
[Graphical view]
SMARTiSM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00084. ruvA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0LUK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISFVSGRVA AVTPDSVIVE VGGFGVQLLA TPATIARARV GERARFATSL
60 70 80 90 100
VVREDSLTLY GFADDDERTV FELLQTASGV GPRLALAMLG VHSPTALRAA
110 120 130 140 150
VATEDVKALA LVPGIGRKTA QRIILELKDR LGTPSTAAAE STSGWRDAVH
160 170 180 190
AGLLNLGYTA RQADEAIAAI AGELDDSAAV DTATALRLAL ATLKRP
Length:196
Mass (Da):20,347
Last modified:December 12, 2006 - v1
Checksum:iF490FAAE67FA92B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA. Translation: ABK53116.1.
RefSeqiWP_011720179.1. NC_008578.1.

Genome annotation databases

EnsemblBacteriaiABK53116; ABK53116; Acel_1344.
KEGGiace:Acel_1344.
PATRICi20673190. VBIAciCel132453_1427.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA. Translation: ABK53116.1.
RefSeqiWP_011720179.1. NC_008578.1.

3D structure databases

ProteinModelPortaliA0LUK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi351607.Acel_1344.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK53116; ABK53116; Acel_1344.
KEGGiace:Acel_1344.
PATRICi20673190. VBIAciCel132453_1427.

Phylogenomic databases

eggNOGiENOG4105KA4. Bacteria.
COG0632. LUCA.
HOGENOMiHOG000057115.
KOiK03550.
OMAiGDDKAFT.
OrthoDBiEOG679THG.

Enzyme and pathway databases

BioCyciACEL351607:GIXW-1374-MONOMER.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00031. DNA_helic_RuvA.
InterProiIPR011114. DNA_helicas_Holl-junc_RuvA_C.
IPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
[Graphical view]
PfamiPF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
[Graphical view]
SMARTiSM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00084. ruvA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43068 / 11B.

Entry informationi

Entry nameiRUVA_ACIC1
AccessioniPrimary (citable) accession number: A0LUK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: December 9, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.