Reviewed, UniProtKB/Swiss-Prot A0LUH1 (AROC_ACIC1)

Names and origin

Protein names

Recommended name:
    Chorismate synthase
    EC=4.2.3.5
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	Acel_1309

Organism

Acidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]

Taxonomic identifier

351607 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	Chorismate synthase HAMAP MF_00300		PRO_0000322380

Sequences

	Sequence		Length	Mass (Da)
	A0LUH1-1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: EF9F45DCEDC3CACB	FASTA	392	41,426
	10 20 30 40 50 60 MLRWLTAGES HGPALVAVLE GLPAGVEITT SVLGDALARR RMGYGRGARM TFERDEVEFL 70 80 90 100 110 120 GGIRHGVTMG GPVAIRIANT EWPKWREVMA ADPVPPEQLA DLARAAPLTR PRPGHADLVG 130 140 150 160 170 180 MQKYHLTDIR PILERASARE TAARVALGTV AAAFLRQAAG IEVLSHVVAI GPVCAPAEPL 190 200 210 220 230 240 PTPADRERID ADPVRCLDPQ ASAAMVAEID AAKKDGDTLG GVVEVLGYGL PPGLGSHVHW 250 260 270 280 290 300 DRRLDARLAA ALMSIQAIKG VEVGDGFATA RRRGSAAHDE IEAGADGVRR RTNRSGGTEG 310 320 330 340 350 360 GMSTGEVLRV RAAMKPISTV PRALDTIDVT TGEPAKAINQ RSDVCAVPAA GVVAEAMVEL 370 380 390 VLADALLEKF GGDHVVETRR NLQAYLDTLV VR

References

[1]

"Complete sequence of Acidothermus cellulolyticus 11B." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000481 Genomic DNA. Translation: ABK53081.1. Different initiation.
RefSeq	YP_873067.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0LUH1.
Genome annotation databases
GeneID	4485464.
GenomeReviews	Gene locus Acel_1309 in contig CP000481_GR.
KEGG	ace:Acel_1309.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00300. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
ProDom	PD002941. Chorismate_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00033. aroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_ACIC1

Accession

Primary (citable) accession number: A0LUH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	September 22, 2009
This is version 17 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)