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A0LUH1 (AROC_ACIC1) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:Acel_1309
OrganismAcidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]
Taxonomic identifier351607 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Subunit structure

Homotetramer By similarity. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Sequence caution

The sequence ABK53081.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Chorismate synthase HAMAP MF_00300
PRO_0000322380

Sequences

Sequence LengthMass (Da)Tools
A0LUH1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: EF9F45DCEDC3CACB

FASTA39241,426
        10         20         30         40         50         60 
MLRWLTAGES HGPALVAVLE GLPAGVEITT SVLGDALARR RMGYGRGARM TFERDEVEFL 

        70         80         90        100        110        120 
GGIRHGVTMG GPVAIRIANT EWPKWREVMA ADPVPPEQLA DLARAAPLTR PRPGHADLVG 

       130        140        150        160        170        180 
MQKYHLTDIR PILERASARE TAARVALGTV AAAFLRQAAG IEVLSHVVAI GPVCAPAEPL 

       190        200        210        220        230        240 
PTPADRERID ADPVRCLDPQ ASAAMVAEID AAKKDGDTLG GVVEVLGYGL PPGLGSHVHW 

       250        260        270        280        290        300 
DRRLDARLAA ALMSIQAIKG VEVGDGFATA RRRGSAAHDE IEAGADGVRR RTNRSGGTEG 

       310        320        330        340        350        360 
GMSTGEVLRV RAAMKPISTV PRALDTIDVT TGEPAKAINQ RSDVCAVPAA GVVAEAMVEL 

       370        380        390 
VLADALLEKF GGDHVVETRR NLQAYLDTLV VR

« Hide

References

[1]"Complete sequence of Acidothermus cellulolyticus 11B."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000481 Genomic DNA. Translation: ABK53081.1. Different initiation.
RefSeqYP_873067.1. NC_008578.1.

3D structure databases

ProteinModelPortalA0LUH1.
SMRA0LUH1. Positions 1-392.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0LUH1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4485464.
GenomeReviewsGene locus Acel_1309 in contig CP000481_GR.
KEGGace:Acel_1309.
PATRIC20673118. VBIAciCel132453_1391.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0082.
HOGENOMHBG292336.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycACEL351607:ACEL_1309-MONOMER.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_ACIC1
AccessionPrimary (citable) accession number: A0LUH1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: December 14, 2011
This is version 32 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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