A0LUG3 (PYRB_ACIC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Acel_1301

Organism

Acidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]

Taxonomic identifier

351607 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000321061

Sequences

	Sequence		Length	Mass (Da)
	A0LUG3 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 91D1605B34EA7B46	FASTA	323	34,531
	10 20 30 40 50 60 MMRHLLSAGD LTRDDALLIL DTAAELARLA DRPIKKLPTL RGRTIVNLFY EDSTRTRTSF 70 80 90 100 110 120 EAAAKRLSAD VINFSAKGSS VSKGESLKDT ALTLEAMGTD AVVIRHWASG APHRLAGWVR 130 140 150 160 170 180 GSVINAGDGT HEHPTQALLD AYTIRRHLGG VDGRRVAIVG DILHSRVARS NVTLLHTLGA 190 200 210 220 230 240 EVTLVAPPTL LPVGVESWPC AVSYELDGVL PKCDAVMLLR VQRERMQAAF FPTSREYSRR 250 260 270 280 290 300 YGLDAARLAL LPEHAIVLHP GPMNRGVEIA AEVADSPRSV VVEQVANGVV VRMAVLYLLL 310 320 GGGEPALAGR AAEPAAAAIG GGW

References

[1]

"Complete sequence of Acidothermus cellulolyticus 11B." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000481 Genomic DNA. Translation: ABK53073.1.
RefSeq	YP_873059.1. NC_008578.1.
3D structure databases
ProteinModelPortal	A0LUG3.
ModBase	Search...
Protein-protein interaction databases
STRING	A0LUG3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4485456.
GenomeReviews	Gene locus Acel_1301 in contig CP000481_GR.
KEGG	ace:Acel_1301.
PATRIC	20673100. VBIAciCel132453_1382.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
HOGENOM	HBG579429.
OMA	LQRERMS.
PhylomeDB	A0LUG3.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	ACEL351607:ACEL_1301-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_ACIC1

Accession

Primary (citable) accession number: A0LUG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program