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A0LUE0

- FMT_ACIC1

UniProt

A0LUE0 - FMT_ACIC1

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Protein
Methionyl-tRNA formyltransferase
Gene
fmt, Acel_1278
Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

  1. methionyl-tRNA formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciACEL351607:GIXW-1308-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferase (EC:2.1.2.9)
Gene namesi
Name:fmt
Ordered Locus Names:Acel_1278
OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
Taxonomic identifieri351607 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeAcidothermaceaeAcidothermus
ProteomesiUP000008221: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Methionyl-tRNA formyltransferaseUniRule annotation
PRO_1000020008Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351607.Acel_1278.

Structurei

3D structure databases

ProteinModelPortaliA0LUE0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni109 – 1124Tetrahydrofolate (THF) binding By similarity

Sequence similaritiesi

Belongs to the Fmt family.

Phylogenomic databases

eggNOGiCOG0223.
HOGENOMiHOG000261177.
KOiK00604.
OMAiRIKLGPV.
OrthoDBiEOG6B09WV.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans.
InterProiIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view]
PANTHERiPTHR11138. PTHR11138. 1 hit.
PfamiPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.

Sequencei

Sequence statusi: Complete.

A0LUE0-1 [UniParc]FASTAAdd to Basket

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MRLLFAGTPQ TALPSLRLLL ESSHEVVAVL TRPDAPAGRG RTPRPSPVAL    50
AAEQAGLPVL KPRRLADPET LAALRSLNAE LAVVVAYGAL VPEPALAIPR 100
HGWVNLHFSI LPSWRGAAPV QHAILHGDEV TGATTFRLEP DLDTGPIYGT 150
VTEPIRPDDT AGDLLNRLAR TGARLLLDTV DGIAAGVLAP RPQPTEGVSY 200
APKITPADAR ISWSSPAFHV DRLIRAVTPE PGAWTTLAGR RIVLGPVRLA 250
EPQHAPGATD DGSLAPGEIR VLAPGEIRVE RDRVLVGTAT TPVILGTVQP 300
AGRRAMPAEA WARGARLAPG ARFE 324
Length:324
Mass (Da):34,193
Last modified:December 12, 2006 - v1
Checksum:i1C21C0D5C7A4EA18
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000481 Genomic DNA. Translation: ABK53050.1.
RefSeqiYP_873036.1. NC_008578.1.

Genome annotation databases

EnsemblBacteriaiABK53050; ABK53050; Acel_1278.
GeneIDi4486349.
KEGGiace:Acel_1278.
PATRICi20673052. VBIAciCel132453_1358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000481 Genomic DNA. Translation: ABK53050.1 .
RefSeqi YP_873036.1. NC_008578.1.

3D structure databases

ProteinModelPortali A0LUE0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351607.Acel_1278.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK53050 ; ABK53050 ; Acel_1278 .
GeneIDi 4486349.
KEGGi ace:Acel_1278.
PATRICi 20673052. VBIAciCel132453_1358.

Phylogenomic databases

eggNOGi COG0223.
HOGENOMi HOG000261177.
KOi K00604.
OMAi RIKLGPV.
OrthoDBi EOG6B09WV.

Enzyme and pathway databases

BioCyci ACEL351607:GIXW-1308-MONOMER.

Family and domain databases

Gene3Di 3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPi MF_00182. Formyl_trans.
InterProi IPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view ]
PANTHERi PTHR11138. PTHR11138. 1 hit.
Pfami PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsi TIGR00460. fmt. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43068 / 11B.

Entry informationi

Entry nameiFMT_ACIC1
AccessioniPrimary (citable) accession number: A0LUE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 12, 2006
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi