A0LUC1 (OTC_ACIC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	Acel_1259

Organism

Acidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]

Taxonomic identifier

351607 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm By similarity HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_1000084832
Regions
	Region	50 – 54	5	Carbamoyl phosphate binding By similarity
	Region	262 – 265	4	Ornithine binding By similarity
Sites
	Binding site	101	1	Carbamoyl phosphate By similarity
	Binding site	128	1	Carbamoyl phosphate By similarity
	Site	27	1	Important for structural integrity By similarity
	Site	141	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0LUC1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 6839A5D0A4D59D36	FASTA	312	33,140
	10 20 30 40 50 60 MIRHFLADDD LTPSEQAAVL DEAARLKKDR YAARPLTGPR SVAVVFEKPS TRTRVSFEVA 70 80 90 100 110 120 ITELGGQPVV LDAVGSQLGR GEPIEDTARV LSRYVAAIVL RTFGHDRITT LARYATVPVV 130 140 150 160 170 180 NALSDAYHPC QALADLLTIR ERKGGLDGVR LAYVGDGNNV ACSLLVAGAM AGLHVTVASP 190 200 210 220 230 240 AGYQPPPAVV ARAAEIGEQT GGRVEVVDDP RTAARNADVL YTDVWTSMGQ EEETAARRRA 250 260 270 280 290 300 FAGFTVDDDL LALAADDAIV LHCLPAHRGE EITASVLEGP QSAIFDQAEN RLHTAKALLS 310 FLLDAAGGRG IP

References

[1]

"Complete sequence of Acidothermus cellulolyticus 11B." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000481 Genomic DNA. Translation: ABK53031.1.
RefSeq	YP_873017.1. NC_008578.1.
3D structure databases
ProteinModelPortal	A0LUC1.
SMR	A0LUC1. Positions 1-304.
ModBase	Search...
Protein-protein interaction databases
STRING	A0LUC1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4485159.
GenomeReviews	Gene locus Acel_1259 in contig CP000481_GR.
KEGG	ace:Acel_1259.
PATRIC	20673010. VBIAciCel132453_1337.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0078.
HOGENOM	HBG579429.
OMA	KHLLSIK.
PhylomeDB	A0LUC1.
Enzyme and pathway databases
BioCyc	ACEL351607:ACEL_1259-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
KO	K00611.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_ACIC1

Accession

Primary (citable) accession number: A0LUC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	December 12, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program