A0LUB8 (ARLY_ACIC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	Acel_1256

Organism

Acidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]

Taxonomic identifier

351607 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	Argininosuccinate lyase HAMAP MF_00006		PRO_0000321423

Sequences

	Sequence		Length	Mass (Da)
	A0LUB8 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 4036CB540AF7A551	FASTA	489	52,078
	10 20 30 40 50 60 MSEPSAAVGQ RPGGESAPAH RLWGGRFTAG PAESVAALSR SIDVDWRLAR YDLRASKAHA 70 80 90 100 110 120 RVLAAAGLLD ADELAQLLAA LDELDRACAS GTFQPAAADE DVHTALERAL LERLGPLGGK 130 140 150 160 170 180 LRAGRSRNDQ IATDLRLYLR DHVRLLVRRL VDLQWALVDQ AERHLDLPAP GMTHLQHAQP 190 200 210 220 230 240 VLFAHHLLAH VAAFARDVDR FRDWDRRAAI CPLGAGALAG SSLPLDPHAV AAELGFTAPA 250 260 270 280 290 300 ANSIDAVSDR DFAAEFAFAA ALVGVHLSRL GEEIVLWCSQ EFGWVELDDA YATGSSIMPQ 310 320 330 340 350 360 KKNPDVAELA RGKAGRLIGN LTSLLTMLKG LPLAYDRDLQ EDKFPVFDSL DTLLLVLPAM 370 380 390 400 410 420 TGLVATMRVK ADRVAAAAPA GFSLATDVAE ALVRRGVPFH EAHQAVGRLV AWCAAHGTDL 430 440 450 460 470 480 SAVDDDQLAE ISPYFTPENR AEVRTVLSVR GAIGARAAYG GTAPERVAEQ LAAVRAALAD SAAWADAAP

References

[1]

"Complete sequence of Acidothermus cellulolyticus 11B." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000481 Genomic DNA. Translation: ABK53028.1.
RefSeq	YP_873014.1. NC_008578.1.
3D structure databases
ProteinModelPortal	A0LUB8.
ModBase	Search...
Protein-protein interaction databases
STRING	A0LUB8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4485156.
GenomeReviews	Gene locus Acel_1256 in contig CP000481_GR.
KEGG	ace:Acel_1256.
PATRIC	20673004. VBIAciCel132453_1334.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0165.
HOGENOM	HBG539632.
OMA	MPGRTHL.
ProtClustDB	PRK00855.
Enzyme and pathway databases
BioCyc	ACEL351607:ACEL_1256-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ACIC1

Accession

Primary (citable) accession number: A0LUB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program