Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transketolase

Gene

Acel_1127

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.UniRule annotation

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Ca2+UniRule annotation, Mn2+UniRule annotation, Co2+UniRule annotationNote: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co2+.UniRule annotation
  • thiamine diphosphateUniRule annotationNote: Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. transketolase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotation

Keywords - Ligandi

CalciumUniRule annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Thiamine pyrophosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciACEL351607:GIXW-1152-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TransketolaseUniRule annotation (EC:2.2.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Acel_1127Imported
OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)Imported
Taxonomic identifieri351607 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeAcidothermaceaeAcidothermus
ProteomesiUP000008221 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi351607.Acel_1127.

Structurei

3D structure databases

ProteinModelPortaliA0LTY9.
SMRiA0LTY9. Positions 11-676.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transketolase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0021.
HOGENOMiHOG000225954.
KOiK00615.
OMAiECWQIAI.
OrthoDBiEOG6N3CRG.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005478. Transketolase_bac-like.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
PF00456. Transketolase_N. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00232. tktlase_bact. 1 hit.
PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0LTY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEHDTVEWT ELDARAVDII RALAMDAVEA AGSGHPGTAM GLAPAAYLLF
60 70 80 90 100
QRLLRHDPTD PRWLGRDRFV LSCGHSSLTL YIQLYLSGYG LTLDDLRSYR
110 120 130 140 150
QWGSLTPGHP EYGHTPGVET TTGPLGQGFG NAVGMAMAAR RERGLFDPDA
160 170 180 190 200
APGSSVFDHT IWVFASDGDI EEGVQAEAAA IAGHQQLGNL VVLYDDNRIS
210 220 230 240 250
IEGDTRVAHS EDVGKRYEAY GWHVQHVADV NDVQALYRAL VTARDTTDRP
260 270 280 290 300
SLVIVRSIIA WPAPNLQNTG KAHGSALGAE EVAATKRVLG LDPEKTFYVP
310 320 330 340 350
DDVLSHARQV VDRGRLAHKE WQERFEAWRA AHPQRAAELD RMLARRLPEG
360 370 380 390 400
WDADIPHFAP DKPMSTRKAS GVVINALAKK LPELWGGSAD LAESNNTTIE
410 420 430 440 450
GERDFLPAAH GGDPYGRVLH FGIREHAMGA ILNGITLHGP TRVFGGTFLV
460 470 480 490 500
FSDYMRPPVR LAAMMKLPVI YVWTHDSIGL GEDGPTHQPV EHLAALRAIP
510 520 530 540 550
GLDVVRPADA NETAVAWRTI MQQTDRPAAL CLTRQNVPVI DRTQYASADG
560 570 580 590 600
TAKGAYVLAE AGSGAPQVIL IATGSEVHLA LAARERLEAD GVPTRVVSMP
610 620 630 640 650
CREWFEAQPE SYRRTVLPDD VRARVSIEAA VALGWRDYVG DFGECVSLEH
660 670 680 690
FGASASYQVL FEQFGFTPER VVAAAHASMA RVRAAGLPVL GS
Length:692
Mass (Da):75,276
Last modified:December 12, 2006 - v1
Checksum:iC503BEE17193683C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA. Translation: ABK52899.1.
RefSeqiWP_011719962.1. NC_008578.1.
YP_872885.1. NC_008578.1.

Genome annotation databases

EnsemblBacteriaiABK52899; ABK52899; Acel_1127.
KEGGiace:Acel_1127.
PATRICi20672712. VBIAciCel132453_1193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA. Translation: ABK52899.1.
RefSeqiWP_011719962.1. NC_008578.1.
YP_872885.1. NC_008578.1.

3D structure databases

ProteinModelPortaliA0LTY9.
SMRiA0LTY9. Positions 11-676.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi351607.Acel_1127.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK52899; ABK52899; Acel_1127.
KEGGiace:Acel_1127.
PATRICi20672712. VBIAciCel132453_1193.

Phylogenomic databases

eggNOGiCOG0021.
HOGENOMiHOG000225954.
KOiK00615.
OMAiECWQIAI.
OrthoDBiEOG6N3CRG.

Enzyme and pathway databases

BioCyciACEL351607:GIXW-1152-MONOMER.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005478. Transketolase_bac-like.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
PF00456. Transketolase_N. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00232. tktlase_bact. 1 hit.
PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43068 / 11BImported.

Entry informationi

Entry nameiA0LTY9_ACIC1
AccessioniPrimary (citable) accession number: A0LTY9
Entry historyi
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: April 29, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.