A0LTM4 (MURC_ACIC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-N-acetylmuramate--L-alanine ligase
EC=6.3.2.8

Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase

Gene names

Name:	murC
Ordered Locus Names:	Acel_1011

Organism

Acidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]

Taxonomic identifier

351607 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length	477 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cell wall formation By similarity. HAMAP MF_00046
Catalytic activity	ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046
Subcellular location	Cytoplasm By similarity HAMAP MF_00046.
Sequence similarities	Belongs to the MurCDEF family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW UDP-N-acetylmuramate-L-alanine ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 477	477	UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046		PRO_0000336807
Regions
	Nucleotide binding	125 – 131	7	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A0LTM4 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: B2FB98C9AD4C6B65	FASTA	477	49,617
	10 20 30 40 50 60 MTSDQSLSHH EPLPLERLGR THFVGVGGGG MSGIARIFLS RGVPVSGCDA RESRVLAALR 70 80 90 100 110 120 AFGARVTVGH DPAHLSDVDT VVASTAVPPT TPELAVARER GLPVLPRAAA LASVMAGRRG 130 140 150 160 170 180 VAVAGTHGKT TTTSMVVRAL QRCGADPSFA IGADLGEPGS NAHDGTGSIF VAEADESDES 190 200 210 220 230 240 FLLLPFHAAV VTNVEADHLN HYADLAAIHA AFDRFVAKVP DGGFLVACTD DPGAEEIASR 250 260 270 280 290 300 AARRGTVVRR YGTSPRADVR LVDLRLEVAG SRFAVAMDGT VLGELQLRVP GAHNALNATA 310 320 330 340 350 360 AVAVTVGLGF PFSEVAEGLA DFTGARRRFQ PQGEVAGIRV FDDYAHHPTE IAATLRAARV 370 380 390 400 410 420 VADGGRLVVA FQPHHYYRTA DFRTEFGAAL ALADEVVVME VYAPGETPLP GGTGAALAAA 430 440 450 460 470 VPLPGSAVVF EPSWSAVPEH LAARARPGDL IVTMGAGGDV ALLPPLVLDA LRRRWQG

References

[1]

"Complete sequence of Acidothermus cellulolyticus 11B." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000481 Genomic DNA. Translation: ABK52784.1.
RefSeq	YP_872770.1. NC_008578.1.
3D structure databases
ProteinModelPortal	A0LTM4.
ModBase	Search...
Protein-protein interaction databases
STRING	A0LTM4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4485015.
GenomeReviews	Gene locus Acel_1011 in contig CP000481_GR.
KEGG	ace:Acel_1011.
PATRIC	20672462. VBIAciCel132453_1069.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0773.
HOGENOM	HBG476594.
OMA	YQPHRYS.
PhylomeDB	A0LTM4.
ProtClustDB	CLSK2782376.
Enzyme and pathway databases
BioCyc	ACEL351607:ACEL_1011-MONOMER.
Family and domain databases
HAMAP	MF_00046. MurC. [Tree]
InterPro	IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR016040. NAD(P)-bd_dom. IPR005758. UDP-N-AcMur_Ala_ligase. [Graphical view]
Gene3D	G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K01924.
PANTHER	PTHR23135:SF5. PTHR23135:SF5. 1 hit.
Pfam	PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view]
SUPFAM	SSF53244. Mur_ligase_C. 1 hit. SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMs	TIGR01082. MurC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURC_ACIC1

Accession

Primary (citable) accession number: A0LTM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program