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A0LTM1 (A0LTM1_ACIC1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP MF_00639 RuleBase RU003664
EC=6.3.2.9 HAMAP MF_00639 RuleBase RU003664
Alternative name(s):
D-glutamic acid-adding enzyme HAMAP MF_00639
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase HAMAP MF_00639
Gene names
Name:murD HAMAP MF_00639
Ordered Locus Names:Acel_1008
OrganismAcidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]
Taxonomic identifier351607 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Subcellular location

Cytoplasm By similarity HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762.

Sequence similarities

Belongs to the MurCDEF family. HAMAP MF_00639 RuleBase RU003630

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding134 – 1407ATP By similarity HAMAP MF_00639

Sequences

Sequence LengthMass (Da)Tools
A0LTM1 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 3A02358CCCDA0CB5

FASTA50953,208
        10         20         30         40         50         60 
MARVSVVPEW LSDAGHDAPW SQLTVCVAGV GISGRAAARV LAALGAQVIA VDDRDGEPER 

        70         80         90        100        110        120 
AAAAELARLG VTVRLGDGAT FPDGVQLIVT SPGWRRESPL FAAAADRGVP VWGEPELAWR 

       130        140        150        160        170        180 
LRRPGDAEWL VITGTDGKTT TTLMLESILR AAGLRTIAAG NIDVPLVEVV NSGYDVLAVE 

       190        200        210        220        230        240 
LGSFQLHWSP SVAPKAAAVL NVAPDHLDWW GGSFTDYANA KGRAFAHPRT CAIGNLDDPQ 

       250        260        270        280        290        300 
TVRLLARAPG RRVGFTLHSP RPDQVGVHDG VLLDRAFVPD PARDVVELAT VTDIPVPGAH 

       310        320        330        340        350        360 
NVANALAAAA LARSIGVEPA AIAAGLRTFT PAAHRIATVA EVDGVRFVDD SKATSPHAAA 

       370        380        390        400        410        420 
ASLTSFDRIV WIAGGLGKDV AFDELVSQVA DRLRGVVLLG ACRHEIADAL RRHAPQVPVI 

       430        440        450        460        470        480 
DVGGAETGDV HAVLDAAVAA AVRYAAPGDV VLLAPAAASY DMFRDYRHRG QAFADAVRRY 

       490        500 
AERRSAAERR EAAAQVGPSG PAESAGGSR

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References

[1]"Complete sequence of Acidothermus cellulolyticus 11B."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000481 Genomic DNA. Translation: ABK52781.1.
RefSeqYP_872767.1. NC_008578.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA0LTM1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4485012.
GenomeReviewsGene locus Acel_1008 in contig CP000481_GR.
KEGGace:Acel_1008.
PATRIC20672456. VBIAciCel132453_1066.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0771.
HOGENOMHBG750024.
OMAACASWDM.

Family and domain databases

HAMAPMF_00639. MurD.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01925.
PANTHERPTHR23135:SF2. PTHR23135:SF2. 1 hit.
PfamPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01087. MurD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA0LTM1_ACIC1
AccessionPrimary (citable) accession number: A0LTM1
Entry history
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: December 14, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info