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Protein

Ribosomal RNA small subunit methyltransferase H

Gene

rsmH

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + N(4)-methylcytosine(1402) in 16S rRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei65 – 651S-adenosyl-L-methionineUniRule annotation
Binding sitei92 – 921S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
Binding sitei113 – 1131S-adenosyl-L-methionineUniRule annotation
Binding sitei120 – 1201S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciACEL351607:GIXW-1026-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase HUniRule annotation (EC:2.1.1.199UniRule annotation)
Alternative name(s):
16S rRNA m(4)C1402 methyltransferaseUniRule annotation
rRNA (cytosine-N(4)-)-methyltransferase RsmHUniRule annotation
Gene namesi
Name:rsmHUniRule annotation
Synonyms:mraW
Ordered Locus Names:Acel_1002
OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
Taxonomic identifieri351607 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaAcidothermalesAcidothermaceaeAcidothermus
Proteomesi
  • UP000008221 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Ribosomal RNA small subunit methyltransferase HPRO_0000386685Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351607.Acel_1002.

Structurei

3D structure databases

ProteinModelPortaliA0LTL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 483S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RsmH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGJ. Bacteria.
COG0275. LUCA.
HOGENOMiHOG000049778.
KOiK03438.
OMAiHVPVMLQ.
OrthoDBiPOG091H02LX.

Family and domain databases

Gene3Di1.10.150.170. 1 hit.
3.40.50.150. 2 hits.
HAMAPiMF_01007. 16SrRNA_methyltr_H. 1 hit.
InterProiIPR002903. RsmH.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11265. PTHR11265. 1 hit.
PfamiPF01795. Methyltransf_5. 1 hit.
[Graphical view]
PIRSFiPIRSF004486. MraW. 1 hit.
SUPFAMiSSF53335. SSF53335. 2 hits.
SSF81799. SSF81799. 1 hit.
TIGRFAMsiTIGR00006. TIGR00006. 1 hit.

Sequencei

Sequence statusi: Complete.

A0LTL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTADPGSSVP PAVVHRPVMV DRVVELLLPA LGYPGAIVVD ATVGLGGHAE
60 70 80 90 100
AVVRAASAAT LIGLDHDPHA IRLAAQRLAG YADRVQLVNV AFDRLAQVLS
110 120 130 140 150
ERGISAVAAI LFDLGLSSLH IDDPARGFAY SRDVPLDMRM DPRLPRTAAD
160 170 180 190 200
VVNTYSATEL ARVLRVYGEE RFAVRIADAI VRRRARQPIT STRDLSELVR
210 220 230 240 250
EAIPAPARRT GGHPAKRTFQ ALRIEVNDEL GRLERTLPVA IAALQPGGRI
260 270 280 290 300
VVLSYHSLED RTVKRFFQAA ASDATPAGLP TALPTARPRL RLLTRGAERP
310 320
SPAEVAANPR AASARLRAAE KIRDTREAA
Length:329
Mass (Da):35,374
Last modified:December 12, 2006 - v1
Checksum:iFF986682E8821618
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA. Translation: ABK52775.1.
RefSeqiWP_011719838.1. NC_008578.1.

Genome annotation databases

EnsemblBacteriaiABK52775; ABK52775; Acel_1002.
KEGGiace:Acel_1002.
PATRICi20672444. VBIAciCel132453_1060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA. Translation: ABK52775.1.
RefSeqiWP_011719838.1. NC_008578.1.

3D structure databases

ProteinModelPortaliA0LTL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi351607.Acel_1002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK52775; ABK52775; Acel_1002.
KEGGiace:Acel_1002.
PATRICi20672444. VBIAciCel132453_1060.

Phylogenomic databases

eggNOGiENOG4105CGJ. Bacteria.
COG0275. LUCA.
HOGENOMiHOG000049778.
KOiK03438.
OMAiHVPVMLQ.
OrthoDBiPOG091H02LX.

Enzyme and pathway databases

BioCyciACEL351607:GIXW-1026-MONOMER.

Family and domain databases

Gene3Di1.10.150.170. 1 hit.
3.40.50.150. 2 hits.
HAMAPiMF_01007. 16SrRNA_methyltr_H. 1 hit.
InterProiIPR002903. RsmH.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11265. PTHR11265. 1 hit.
PfamiPF01795. Methyltransf_5. 1 hit.
[Graphical view]
PIRSFiPIRSF004486. MraW. 1 hit.
SUPFAMiSSF53335. SSF53335. 2 hits.
SSF81799. SSF81799. 1 hit.
TIGRFAMsiTIGR00006. TIGR00006. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRSMH_ACIC1
AccessioniPrimary (citable) accession number: A0LTL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: December 12, 2006
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.