A0LTL5 (RSMH_ACIC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal RNA small subunit methyltransferase H
EC=2.1.1.199

Alternative name(s):
16S rRNA m(4)C1402 methyltransferase
rRNA (cytosine-N(4)-)-methyltransferase RsmH

Gene names

Name:	rsmH
Synonyms:	mraW
Ordered Locus Names:	Acel_1002

Organism

Acidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]

Taxonomic identifier

351607 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA By similarity. HAMAP MF_01007
Catalytic activity	S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + N(4)-methylcytosine(1402) in 16S rRNA. HAMAP MF_01007
Subcellular location	Cytoplasm By similarity HAMAP MF_01007.
Sequence similarities	Belongs to the methyltransferase superfamily. RsmH family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	rRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 329	329	Ribosomal RNA small subunit methyltransferase H HAMAP MF_01007		PRO_0000386685
Regions
	Region	46 – 48	3	S-adenosyl-L-methionine binding By similarity
Sites
	Binding site	65	1	S-adenosyl-L-methionine By similarity
	Binding site	92	1	S-adenosyl-L-methionine; via amide nitrogen By similarity
	Binding site	113	1	S-adenosyl-L-methionine By similarity
	Binding site	120	1	S-adenosyl-L-methionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0LTL5 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: FF986682E8821618	FASTA	329	35,374
	10 20 30 40 50 60 MTADPGSSVP PAVVHRPVMV DRVVELLLPA LGYPGAIVVD ATVGLGGHAE AVVRAASAAT 70 80 90 100 110 120 LIGLDHDPHA IRLAAQRLAG YADRVQLVNV AFDRLAQVLS ERGISAVAAI LFDLGLSSLH 130 140 150 160 170 180 IDDPARGFAY SRDVPLDMRM DPRLPRTAAD VVNTYSATEL ARVLRVYGEE RFAVRIADAI 190 200 210 220 230 240 VRRRARQPIT STRDLSELVR EAIPAPARRT GGHPAKRTFQ ALRIEVNDEL GRLERTLPVA 250 260 270 280 290 300 IAALQPGGRI VVLSYHSLED RTVKRFFQAA ASDATPAGLP TALPTARPRL RLLTRGAERP 310 320 SPAEVAANPR AASARLRAAE KIRDTREAA

References

[1]

"Complete sequence of Acidothermus cellulolyticus 11B." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000481 Genomic DNA. Translation: ABK52775.1.
RefSeq	YP_872761.1. NC_008578.1.
3D structure databases
ProteinModelPortal	A0LTL5.
ModBase	Search...
Protein-protein interaction databases
STRING	A0LTL5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4485006.
GenomeReviews	Gene locus Acel_1002 in contig CP000481_GR.
KEGG	ace:Acel_1002.
PATRIC	20672444. VBIAciCel132453_1060.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0275.
HOGENOM	HBG302779.
OMA	NPATRAF.
Enzyme and pathway databases
BioCyc	ACEL351607:ACEL_1002-MONOMER.
Family and domain databases
HAMAP	MF_01007. 16SrRNA_methyltr_H. [Tree]
InterPro	IPR002903. SAM-dep_MeTrfase_MraW. IPR023397. SAM-dep_MeTrfase_MraW_recog. [Graphical view]
Gene3D	G3DSA:1.10.150.170. G3DSA:1.10.150.170. 1 hit.
KO	K03438.
PANTHER	PTHR11265. Bact_methyltrans. 1 hit.
Pfam	PF01795. Methyltransf_5. 1 hit. [Graphical view]
PIRSF	PIRSF004486. MraW. 1 hit.
SUPFAM	SSF81799. SSF81799. 1 hit.
TIGRFAMs	TIGR00006. TIGR00006. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RSMH_ACIC1

Accession

Primary (citable) accession number: A0LTL5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program