A0LTK8 (A0LTK8_ACIC1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Error-prone DNA polymerase HAMAP MF_01902
EC=2.7.7.7 HAMAP MF_01902

Gene names

Name:	dnaE2 HAMAP MF_01902
Ordered Locus Names:	Acel_0995

Organism

Acidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]

Taxonomic identifier

351607 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length	1090 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity. HAMAP MF_01902
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902 SAAS SAAS004013
Subcellular location	Cytoplasm By similarity HAMAP MF_01902 SAAS SAAS004013.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily. HAMAP MF_01902

Ontologies

Keywords
Biological process	DNA damage DNA repair HAMAP MF_01902 SAAS SAAS004013 DNA replication HAMAP MF_01902 SAAS SAAS004013
Cellular component	Cytoplasm HAMAP MF_01902 SAAS SAAS023073
Molecular function	DNA-directed DNA polymerase HAMAP MF_01902 SAAS SAAS004013 Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: HAMAP DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0LTK8 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 9A0C88BCCA55BFFC	FASTA	1,090	119,957
	10 20 30 40 50 60 MGWHNPSVSW PELERRLAGR PARAVEPADA EAPTSRRRPP YRPKELPKQP DETVRYAELH 70 80 90 100 110 120 CHSNFSFLDG ASHPEELVEE AARLGLETLA LTDHDGFYGV VRFAEAAAEL GVRTVFGAEL 130 140 150 160 170 180 SLSLVEPRAG AVDPDAVHLL VLARDPEGYR RLAVAMSAAH LRGGGKGRPQ YDETELAHTA 190 200 210 220 230 240 GGHWLILTGC RKGRVRRALA AEGPDGAVRE IDRLVEMFGR ENVAVELTDD GQPLDSAAND 250 260 270 280 290 300 VLAAAAVRCG LPVVATTNAH YATPDRGRLA AALAAVRARK SLDEIAGWLP AAPVRHLRSG 310 320 330 340 350 360 VEMAQRFARY PGAVANAARL GAACAFDVRL IAPRLPDFPV PPGHTEMSYL RELAMRGAAE 370 380 390 400 410 420 KYGPPHQRPD VYRQLDYELD VIEQLGFPGY FLVVWEIVEF CRSRGILCQG RGSAANSVVC 430 440 450 460 470 480 YVLGITKADP IAFRLLFERF LSPERDGPPD IDVDIESGRR EEVIQYVYSR YGRERAAQVA 490 500 510 520 530 540 TVITYRPRSA VRDMARALGY SPGQQDAWSK QLDRYGEIPR GSEADHDVPD DVVHLARQVL 550 560 570 580 590 600 GFPRHLGIHS GGMVICDRPV AEVCPVEWAR MPGRSVLQWD KDDCARIGVV KFDLLGLGML 610 620 630 640 650 660 SALRECFDLI ETYHGVRLSL ETIPPEDPAV YDMLCAADSV GVFQVESRAQ MATLPRLQPR 670 680 690 700 710 720 NFYDLVTEVA IIRPGPIQGG SVHPFIRRRR GREPVRYAHP LLRHSLERTY GVPLFQEQIM 730 740 750 760 770 780 QMAIDVAGLT PAEADHLRQA MGAKRSVERM ERLKAKLYAG MARNGITGAV ADEIYEKLQA 790 800 810 820 830 840 FAHFGFPESH AISFAFLVYA SAWLKKYYPA AFCAALLNAA PLGFYSPQTV VADARRHGVV 850 860 870 880 890 900 IRRPCVASSA TKTILEPMDG GWAVRLGLSL VKGVSAETAD RIVARRPYRD MADLARRCEL 910 920 930 940 950 960 SVTHLEALAA AGACECFGLD RRQALWLAGS AAETRPGQLE GFGVEATPPR LPPMTEMETT 970 980 990 1000 1010 1020 VTDLRFLGIS PDVYPTAHVR DQLTEMGVVP AAQLHRVAPD SRVLVGGVVT HWQRPATARG 1030 1040 1050 1060 1070 1080 TTFLNVEDET GMVNVICSPG VWVRYRRTAR TAAALLVRGR LERADGVVNV IADRLEPLPL 1090 VIRRSARDFR

References

[1]

"Complete sequence of Acidothermus cellulolyticus 11B." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000481 Genomic DNA. Translation: ABK52768.1.
RefSeq	YP_872754.1. NC_008578.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0LTK8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4485938.
GenomeReviews	Gene locus Acel_0995 in contig CP000481_GR.
KEGG	ace:Acel_0995.
PATRIC	20672432. VBIAciCel132453_1054.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0587.
HOGENOM	HBG734490.
OMA	EQPAIRL.
ProtClustDB	PRK05672.
Family and domain databases
HAMAP	MF_01902. DNApol_error_prone. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR023073. DNA_pol_error_prone. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view]
KO	K14162.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0LTK8_ACIC1

Accession

Primary (citable) accession number: A0LTK8

Entry history

Integrated into UniProtKB/TrEMBL:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)