A0LTK4 (A0LTK4_ACIC1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

Ordered Locus Names:

Acel_0991

Organism

Acidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]

Taxonomic identifier

351607 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU004255
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004255
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862 EMBL ABK52764.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0LTK4 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 84B21F4DACCCBD52	FASTA	331	35,935
	10 20 30 40 50 60 MSTGRLIPAP GRSPTIRELL ARGGSSFSFE FFPPKTADGE RALFQTIRAL EVLRPTFVSV 70 80 90 100 110 120 TYGAGGSTAA ATVRITERIA TETTLTPVGH LTIVNQSVAE IRRVIGQYAA AGVRNILALR 130 140 150 160 170 180 GDPPGNPNGE WIPHPHGFRY AVELVRLLKM VGDFCVGVAA FPRKHPRSPT LEDDTRYFVE 190 200 210 220 230 240 KCRAGADFAI TQMFFRVEDY LRLRERIERA GCTVPIIPGV MPITSIGQIE RFALLSGDEF 250 260 270 280 290 300 PPELADRILA VADQPAAVRA IGIEVATEMC RRLLDEGAPG LHFYTLNRST ATREIYQNLR 310 320 330 LSERADRHGK ASVSGPGVAP SDVAGIAAGE A

References

[1]

"Complete sequence of Acidothermus cellulolyticus 11B." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000481 Genomic DNA. Translation: ABK52764.1.
RefSeq	YP_872750.1. NC_008578.1.
3D structure databases
ProteinModelPortal	A0LTK4.
ModBase	Search...
Protein-protein interaction databases
STRING	A0LTK4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4485934.
GenomeReviews	Gene locus Acel_0991 in contig CP000481_GR.
KEGG	ace:Acel_0991.
PATRIC	20672424. VBIAciCel132453_1050.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0685.
HOGENOM	HBG649727.
OMA	ITQMFFD.
PhylomeDB	A0LTK4.
Family and domain databases
InterPro	IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00676. Fadh2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0LTK4_ACIC1

Accession

Primary (citable) accession number: A0LTK4

Entry history

Integrated into UniProtKB/TrEMBL:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)