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A0LT90 (A0LT90_ACIC1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815
Ordered Locus Names:Acel_0877
OrganismAcidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]
Taxonomic identifier351607 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region260 – 2645ACP-binding By similarity HAMAP MF_01815

Sites

Active site1191 By similarity HAMAP MF_01815
Active site2591 By similarity HAMAP MF_01815
Active site2901 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
A0LT90 [UniParc].

Last modified December 12, 2006. Version 1.
Checksum: 78DCF8F39BE00D14

FASTA33434,651
        10         20         30         40         50         60 
MNAASGAPGS RILSVGEYRP ARVVTNDEIC QRIDSSDAWI RERTGIVTRR FAGDDETVVS 

        70         80         90        100        110        120 
MAAAASAKAL ADAGIEPEDV DLVIVATCSH PLQTPGASSE VQHLIGAIRA GAYDLNAACA 

       130        140        150        160        170        180 
GFCYGLAMAD AAIRSGAARY VVLAGSERMT DFIDPTDRGM AFLFGDGAGA VVVGPADRPG 

       190        200        210        220        230        240 
IGPVAWGSDG SQSRLIYQQP TYVEVQRALA AGSLVEPVAL RMVGPSVFRW AVTQMAPVAR 

       250        260        270        280        290        300 
RALDLAGVRP AELGAFIPHQ ANLRIVESLA KALDLPPSTV IARDIETQGN TSSASIPLAM 

       310        320        330 
AALIEQGQVQ SGQPALLIGF GAGLTYAAQV VEIP

« Hide

References

[1]"Complete sequence of Acidothermus cellulolyticus 11B."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43068 / 11B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000481 Genomic DNA. Translation: ABK52650.1.
RefSeqYP_872636.1. NC_008578.1.

3D structure databases

ProteinModelPortalA0LT90.
SMRA0LT90. Positions 1-334.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0LT90.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4485655.
GenomeReviewsGene locus Acel_0877 in contig CP000481_GR.
KEGGace:Acel_0877.
PATRIC20672180. VBIAciCel132453_0929.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0332.
HOGENOMHBG649927.
OMASNCFIFA.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA0LT90_ACIC1
AccessionPrimary (citable) accession number: A0LT90
Entry history
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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