Reviewed, UniProtKB/Swiss-Prot A0LT86 (ARAA_ACIC1)

Names and origin

Protein names

Recommended name:
    L-arabinose isomerase
    EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	Acel_0873

Organism

Acidothermus cellulolyticus (strain ATCC 43068 / 11B) [Complete proteome] [HAMAP]

Taxonomic identifier

351607 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Acidothermaceae › Acidothermus

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity.
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity.
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	L-arabinose isomerase HAMAP MF_00519		PRO_0000312596
Sites
	Metal binding	307	1	Manganese By similarity
	Metal binding	334	1	Manganese By similarity
	Metal binding	351	1	Manganese By similarity
	Metal binding	450	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0LT86-1 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: 91128D1CBC0FF35A	FASTA	501	54,768
	10 20 30 40 50 60 MTDLPYPEYE CWFLTGSQHL YGEDVLSAVA RQSQAIVEAL NAAGLPVRLV WKPVLTDATG 70 80 90 100 110 120 IRRMCSEASA TDACIGVIAW MHTFSPAKAW INGLLALRKP LLHLHTQANL TLPWSTIDMD 130 140 150 160 170 180 FMNLNQAAHG DREFGYVAAR LAIPRKIVTG HFSDPDVVRD IAAWQRAAAG LADLRSTRLV 190 200 210 220 230 240 RFGDTMRNVA VTDGDRVEAQ IRLGSAIETY GVHDLGVRVD AVAESDVDAL VDRYLADYDM 250 260 270 280 290 300 APELTIGGAR HESLRYAAKL ELALRSFLHD GRFTAFTTNF EDLGPLRQLP GIAVQRLMAD 310 320 330 340 350 360 GFGFGAEGDW KTALLVRAVK TMSRGLPGGT SFMEDYTYHL EPSGRLVLGA HMLEVCPTLT 370 380 390 400 410 420 SATPRCEIHP LLMGGREDPV RLVFTADPAP AVIVGLCDMG DRLRLVANTA DLVAPPEPLP 430 440 450 460 470 480 RLPVARAVWQ PHPELKTAAT AWIAAGGPHH TALSTAVSAR EIRDFARMAG LELVLIDEHT 490 500 ALDAALDRLW AIEQTRASRP W

References

[1]

"Complete sequence of Acidothermus cellulolyticus 11B." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Zharchuk I., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. , Berry A.M., Adney W.S., Normand P., Leu D., Pujic P., Richardson P. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000481 Genomic DNA. Translation: ABK52646.1.
RefSeq	YP_872632.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A0LT86.
Genome annotation databases
GeneID	4485651.
GenomeReviews	Gene locus Acel_0873 in contig CP000481_GR.
KEGG	ace:Acel_0873.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	IASESIK.
Family and domain databases
HAMAP	MF_00519. [Tree]
InterPro	IPR003762. Lara_isomerase. [Graphical view]
Pfam	PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

ARAA_ACIC1

Accession

Primary (citable) accession number: A0LT86

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	December 12, 2006
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)