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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei601ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACEL351607:G1G7K-788-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Acel_0771
OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
Taxonomic identifieri351607 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaAcidothermalesAcidothermaceaeAcidothermus
Proteomesi
  • UP000008221 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347241 – 832Leucine--tRNA ligaseAdd BLAST832

Proteomic databases

PRIDEiA0LSY4

Interactioni

Protein-protein interaction databases

STRINGi351607.Acel_0771

Structurei

3D structure databases

ProteinModelPortaliA0LSY4
SMRiA0LSY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi58 – 68"HIGH" regionAdd BLAST11
Motifi598 – 602"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiDIDWADV
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A0LSY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLGSPLGR LTAVTSEIYD FAAIQARWLP VWTELDPFRA SDDPSDPRER
60 70 80 90 100
RYMLDMFPYP SGDLHMGHAE AFAIGDVVAR YWFQRGYNVL HPIGWDAFGL
110 120 130 140 150
PAENAAIQRN LHPADWTYRN IETQAASFRN YAISFDWSRR LHTCDPEYYK
160 170 180 190 200
WTQWLFLRLF ERGLAYRKAS PVNWCPNDQT VLANEQVVGG TCERCGAQVT
210 220 230 240 250
KKTLTQWYFR ITEYAQRLLD DMALLEGRWP ERVLTMQRNW IGRSEGAYVD
260 270 280 290 300
FTIEGRAEPV TVFTTRPDTL YGATFFVIAA DSPLAAEICA PEQRAAFEAY
310 320 330 340 350
VDQVRRLSDI DRLSTERQKT GVFLGRYAVN PVNGERIPVW AADYVLADYG
360 370 380 390 400
TGAIMAVPAH DQRDLDFALT YGLPVRVVVD TGEGDPAVTG VATEGDGVHI
410 420 430 440 450
NSGLIDGTDK AEGIARITRY LEDIGKGRAG VTYRLRDWLV SRQRFWGAPI
460 470 480 490 500
PIVHCPGCGE VAVPDQDLPV LLPDLRGADL APKGISPLAG AADWVQTTCP
510 520 530 540 550
RCGGSAQRDT DTMDTFVDSS WYYLRYCSPH DPSQPFDVAK VRQWLPVHQY
560 570 580 590 600
VGGVEHAILH LLYSRFITKV LHDMGLVDFV EPFSALLNQG QVINQGKAMS
610 620 630 640 650
KSLGNGVDLG EQLATYGVDA VRLTMVFAGP PEEDIDWADM NPGALGKFLA
660 670 680 690 700
RVWRIAGEVT SPVGAPPKDG DPALRRVTHR TIREVTELVE SFRFNVAVAR
710 720 730 740 750
VMELANALRK AIDTGPGPAD PAVREGAEAL AVMLSLFAPY TAEECWARLG
760 770 780 790 800
HQPTVAKAGW PTPDPELLAQ EEVTCVVQVN GKVRERLRVS PSISEEELRA
810 820 830
AALAAPAVEK AIDGRPVQRI IVRAPKLVNV VV
Length:832
Mass (Da):92,222
Last modified:December 12, 2006 - v1
Checksum:i68DA050860DB42E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA Translation: ABK52544.1
RefSeqiWP_011719607.1, NC_008578.1

Genome annotation databases

EnsemblBacteriaiABK52544; ABK52544; Acel_0771
KEGGiace:Acel_0771

Similar proteinsi

Entry informationi

Entry nameiSYL_ACIC1
AccessioniPrimary (citable) accession number: A0LSY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 12, 2006
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health