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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei601 – 6011ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACEL351607:GIXW-788-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Acel_0771
OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
Taxonomic identifieri351607 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaAcidothermalesAcidothermaceaeAcidothermus
ProteomesiUP000008221 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 832832Leucine--tRNA ligasePRO_0000334724Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351607.Acel_0771.

Structurei

3D structure databases

ProteinModelPortaliA0LSY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi58 – 6811"HIGH" regionAdd
BLAST
Motifi598 – 6025"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiLHMGHAE.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0LSY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLGSPLGR LTAVTSEIYD FAAIQARWLP VWTELDPFRA SDDPSDPRER
60 70 80 90 100
RYMLDMFPYP SGDLHMGHAE AFAIGDVVAR YWFQRGYNVL HPIGWDAFGL
110 120 130 140 150
PAENAAIQRN LHPADWTYRN IETQAASFRN YAISFDWSRR LHTCDPEYYK
160 170 180 190 200
WTQWLFLRLF ERGLAYRKAS PVNWCPNDQT VLANEQVVGG TCERCGAQVT
210 220 230 240 250
KKTLTQWYFR ITEYAQRLLD DMALLEGRWP ERVLTMQRNW IGRSEGAYVD
260 270 280 290 300
FTIEGRAEPV TVFTTRPDTL YGATFFVIAA DSPLAAEICA PEQRAAFEAY
310 320 330 340 350
VDQVRRLSDI DRLSTERQKT GVFLGRYAVN PVNGERIPVW AADYVLADYG
360 370 380 390 400
TGAIMAVPAH DQRDLDFALT YGLPVRVVVD TGEGDPAVTG VATEGDGVHI
410 420 430 440 450
NSGLIDGTDK AEGIARITRY LEDIGKGRAG VTYRLRDWLV SRQRFWGAPI
460 470 480 490 500
PIVHCPGCGE VAVPDQDLPV LLPDLRGADL APKGISPLAG AADWVQTTCP
510 520 530 540 550
RCGGSAQRDT DTMDTFVDSS WYYLRYCSPH DPSQPFDVAK VRQWLPVHQY
560 570 580 590 600
VGGVEHAILH LLYSRFITKV LHDMGLVDFV EPFSALLNQG QVINQGKAMS
610 620 630 640 650
KSLGNGVDLG EQLATYGVDA VRLTMVFAGP PEEDIDWADM NPGALGKFLA
660 670 680 690 700
RVWRIAGEVT SPVGAPPKDG DPALRRVTHR TIREVTELVE SFRFNVAVAR
710 720 730 740 750
VMELANALRK AIDTGPGPAD PAVREGAEAL AVMLSLFAPY TAEECWARLG
760 770 780 790 800
HQPTVAKAGW PTPDPELLAQ EEVTCVVQVN GKVRERLRVS PSISEEELRA
810 820 830
AALAAPAVEK AIDGRPVQRI IVRAPKLVNV VV
Length:832
Mass (Da):92,222
Last modified:December 12, 2006 - v1
Checksum:i68DA050860DB42E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA. Translation: ABK52544.1.
RefSeqiWP_011719607.1. NC_008578.1.
YP_872530.1. NC_008578.1.

Genome annotation databases

EnsemblBacteriaiABK52544; ABK52544; Acel_0771.
KEGGiace:Acel_0771.
PATRICi20671946. VBIAciCel132453_0815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000481 Genomic DNA. Translation: ABK52544.1.
RefSeqiWP_011719607.1. NC_008578.1.
YP_872530.1. NC_008578.1.

3D structure databases

ProteinModelPortaliA0LSY4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi351607.Acel_0771.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABK52544; ABK52544; Acel_0771.
KEGGiace:Acel_0771.
PATRICi20671946. VBIAciCel132453_0815.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiLHMGHAE.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciACEL351607:GIXW-788-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43068 / 11B.

Entry informationi

Entry nameiSYL_ACIC1
AccessioniPrimary (citable) accession number: A0LSY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 12, 2006
Last modified: June 24, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.