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A0LSY4

- SYL_ACIC1

UniProt

A0LSY4 - SYL_ACIC1

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei601 – 6011ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciACEL351607:GIXW-788-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Acel_0771
OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
Taxonomic identifieri351607 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeAcidothermaceaeAcidothermus
ProteomesiUP000008221: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 832832Leucine--tRNA ligasePRO_0000334724Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi351607.Acel_0771.

Structurei

3D structure databases

ProteinModelPortaliA0LSY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi58 – 6811"HIGH" regionAdd
BLAST
Motifi598 – 6025"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiEICAPEQ.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0LSY4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGLGSPLGR LTAVTSEIYD FAAIQARWLP VWTELDPFRA SDDPSDPRER
60 70 80 90 100
RYMLDMFPYP SGDLHMGHAE AFAIGDVVAR YWFQRGYNVL HPIGWDAFGL
110 120 130 140 150
PAENAAIQRN LHPADWTYRN IETQAASFRN YAISFDWSRR LHTCDPEYYK
160 170 180 190 200
WTQWLFLRLF ERGLAYRKAS PVNWCPNDQT VLANEQVVGG TCERCGAQVT
210 220 230 240 250
KKTLTQWYFR ITEYAQRLLD DMALLEGRWP ERVLTMQRNW IGRSEGAYVD
260 270 280 290 300
FTIEGRAEPV TVFTTRPDTL YGATFFVIAA DSPLAAEICA PEQRAAFEAY
310 320 330 340 350
VDQVRRLSDI DRLSTERQKT GVFLGRYAVN PVNGERIPVW AADYVLADYG
360 370 380 390 400
TGAIMAVPAH DQRDLDFALT YGLPVRVVVD TGEGDPAVTG VATEGDGVHI
410 420 430 440 450
NSGLIDGTDK AEGIARITRY LEDIGKGRAG VTYRLRDWLV SRQRFWGAPI
460 470 480 490 500
PIVHCPGCGE VAVPDQDLPV LLPDLRGADL APKGISPLAG AADWVQTTCP
510 520 530 540 550
RCGGSAQRDT DTMDTFVDSS WYYLRYCSPH DPSQPFDVAK VRQWLPVHQY
560 570 580 590 600
VGGVEHAILH LLYSRFITKV LHDMGLVDFV EPFSALLNQG QVINQGKAMS
610 620 630 640 650
KSLGNGVDLG EQLATYGVDA VRLTMVFAGP PEEDIDWADM NPGALGKFLA
660 670 680 690 700
RVWRIAGEVT SPVGAPPKDG DPALRRVTHR TIREVTELVE SFRFNVAVAR
710 720 730 740 750
VMELANALRK AIDTGPGPAD PAVREGAEAL AVMLSLFAPY TAEECWARLG
760 770 780 790 800
HQPTVAKAGW PTPDPELLAQ EEVTCVVQVN GKVRERLRVS PSISEEELRA
810 820 830
AALAAPAVEK AIDGRPVQRI IVRAPKLVNV VV
Length:832
Mass (Da):92,222
Last modified:December 12, 2006 - v1
Checksum:i68DA050860DB42E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000481 Genomic DNA. Translation: ABK52544.1.
RefSeqiWP_011719607.1. NC_008578.1.
YP_872530.1. NC_008578.1.

Genome annotation databases

EnsemblBacteriaiABK52544; ABK52544; Acel_0771.
GeneIDi4485307.
KEGGiace:Acel_0771.
PATRICi20671946. VBIAciCel132453_0815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000481 Genomic DNA. Translation: ABK52544.1 .
RefSeqi WP_011719607.1. NC_008578.1.
YP_872530.1. NC_008578.1.

3D structure databases

ProteinModelPortali A0LSY4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 351607.Acel_0771.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABK52544 ; ABK52544 ; Acel_0771 .
GeneIDi 4485307.
KEGGi ace:Acel_0771.
PATRICi 20671946. VBIAciCel132453_0815.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi EICAPEQ.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ACEL351607:GIXW-788-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43068 / 11B.

Entry informationi

Entry nameiSYL_ACIC1
AccessioniPrimary (citable) accession number: A0LSY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 12, 2006
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3