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A0LSY4

- SYL_ACIC1

UniProt

A0LSY4 - SYL_ACIC1

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Acidothermus cellulolyticus (strain ATCC 43068 / 11B)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (12 Dec 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei601 – 6011ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciACEL351607:GIXW-788-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Acel_0771
    OrganismiAcidothermus cellulolyticus (strain ATCC 43068 / 11B)
    Taxonomic identifieri351607 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesFrankineaeAcidothermaceaeAcidothermus
    ProteomesiUP000008221: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 832832Leucine--tRNA ligasePRO_0000334724Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi351607.Acel_0771.

    Structurei

    3D structure databases

    ProteinModelPortaliA0LSY4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi58 – 6811"HIGH" regionAdd
    BLAST
    Motifi598 – 6025"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiEICAPEQ.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0LSY4-1 [UniParc]FASTAAdd to Basket

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    MAGLGSPLGR LTAVTSEIYD FAAIQARWLP VWTELDPFRA SDDPSDPRER    50
    RYMLDMFPYP SGDLHMGHAE AFAIGDVVAR YWFQRGYNVL HPIGWDAFGL 100
    PAENAAIQRN LHPADWTYRN IETQAASFRN YAISFDWSRR LHTCDPEYYK 150
    WTQWLFLRLF ERGLAYRKAS PVNWCPNDQT VLANEQVVGG TCERCGAQVT 200
    KKTLTQWYFR ITEYAQRLLD DMALLEGRWP ERVLTMQRNW IGRSEGAYVD 250
    FTIEGRAEPV TVFTTRPDTL YGATFFVIAA DSPLAAEICA PEQRAAFEAY 300
    VDQVRRLSDI DRLSTERQKT GVFLGRYAVN PVNGERIPVW AADYVLADYG 350
    TGAIMAVPAH DQRDLDFALT YGLPVRVVVD TGEGDPAVTG VATEGDGVHI 400
    NSGLIDGTDK AEGIARITRY LEDIGKGRAG VTYRLRDWLV SRQRFWGAPI 450
    PIVHCPGCGE VAVPDQDLPV LLPDLRGADL APKGISPLAG AADWVQTTCP 500
    RCGGSAQRDT DTMDTFVDSS WYYLRYCSPH DPSQPFDVAK VRQWLPVHQY 550
    VGGVEHAILH LLYSRFITKV LHDMGLVDFV EPFSALLNQG QVINQGKAMS 600
    KSLGNGVDLG EQLATYGVDA VRLTMVFAGP PEEDIDWADM NPGALGKFLA 650
    RVWRIAGEVT SPVGAPPKDG DPALRRVTHR TIREVTELVE SFRFNVAVAR 700
    VMELANALRK AIDTGPGPAD PAVREGAEAL AVMLSLFAPY TAEECWARLG 750
    HQPTVAKAGW PTPDPELLAQ EEVTCVVQVN GKVRERLRVS PSISEEELRA 800
    AALAAPAVEK AIDGRPVQRI IVRAPKLVNV VV 832
    Length:832
    Mass (Da):92,222
    Last modified:December 12, 2006 - v1
    Checksum:i68DA050860DB42E0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000481 Genomic DNA. Translation: ABK52544.1.
    RefSeqiWP_011719607.1. NC_008578.1.
    YP_872530.1. NC_008578.1.

    Genome annotation databases

    EnsemblBacteriaiABK52544; ABK52544; Acel_0771.
    GeneIDi4485307.
    KEGGiace:Acel_0771.
    PATRICi20671946. VBIAciCel132453_0815.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000481 Genomic DNA. Translation: ABK52544.1 .
    RefSeqi WP_011719607.1. NC_008578.1.
    YP_872530.1. NC_008578.1.

    3D structure databases

    ProteinModelPortali A0LSY4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 351607.Acel_0771.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABK52544 ; ABK52544 ; Acel_0771 .
    GeneIDi 4485307.
    KEGGi ace:Acel_0771.
    PATRICi 20671946. VBIAciCel132453_0815.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi EICAPEQ.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci ACEL351607:GIXW-788-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43068 / 11B.

    Entry informationi

    Entry nameiSYL_ACIC1
    AccessioniPrimary (citable) accession number: A0LSY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: December 12, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3